ANGEL2 phosphatase activity is required for non-canonical mitochondrial RNA processing
A subset of mitochondrial transcripts is not flanked by tRNAs and thus does not conform to the canonical mode of processing. Here, Clemente et al. demonstrate that phosphatase activity of ANGEL2 is required for correct processing of these transcripts.
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-33368-9 |
| _version_ | 1828108287191547904 |
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| author | Paula Clemente Javier Calvo-Garrido Sarah F. Pearce Florian A. Schober Megumi Shigematsu Stefan J. Siira Isabelle Laine Henrik Spåhr Christian Steinmetzger Katja Petzold Yohei Kirino Rolf Wibom Oliver Rackham Aleksandra Filipovska Joanna Rorbach Christoph Freyer Anna Wredenberg |
| author_facet | Paula Clemente Javier Calvo-Garrido Sarah F. Pearce Florian A. Schober Megumi Shigematsu Stefan J. Siira Isabelle Laine Henrik Spåhr Christian Steinmetzger Katja Petzold Yohei Kirino Rolf Wibom Oliver Rackham Aleksandra Filipovska Joanna Rorbach Christoph Freyer Anna Wredenberg |
| author_sort | Paula Clemente |
| collection | DOAJ |
| description | A subset of mitochondrial transcripts is not flanked by tRNAs and thus does not conform to the canonical mode of processing. Here, Clemente et al. demonstrate that phosphatase activity of ANGEL2 is required for correct processing of these transcripts. |
| first_indexed | 2024-04-11T10:44:23Z |
| format | Article |
| id | doaj.art-72badb54eeff4560ac9bcd8f356122f9 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T10:44:23Z |
| publishDate | 2022-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-72badb54eeff4560ac9bcd8f356122f92022-12-22T04:29:06ZengNature PortfolioNature Communications2041-17232022-09-0113111510.1038/s41467-022-33368-9ANGEL2 phosphatase activity is required for non-canonical mitochondrial RNA processingPaula Clemente0Javier Calvo-Garrido1Sarah F. Pearce2Florian A. Schober3Megumi Shigematsu4Stefan J. Siira5Isabelle Laine6Henrik Spåhr7Christian Steinmetzger8Katja Petzold9Yohei Kirino10Rolf Wibom11Oliver Rackham12Aleksandra Filipovska13Joanna Rorbach14Christoph Freyer15Anna Wredenberg16Department of Medical Biochemistry and Biophysics, Karolinska InstitutetDepartment of Medical Biochemistry and Biophysics, Karolinska InstitutetDepartment of Medical Biochemistry and Biophysics, Karolinska InstitutetDepartment of Medical Biochemistry and Biophysics, Karolinska InstitutetComputational Medicine Center, Sidney Kimmel Medical College, Thomas Jefferson UniversityHarry Perkins Institute of Medical Research, QEII Medical Centre and University of Western AustraliaDepartment of Medical Biochemistry and Biophysics, Karolinska InstitutetDepartment of Medical Biochemistry and Biophysics, Karolinska InstitutetDepartment of Medical Biochemistry and Biophysics, Karolinska InstitutetDepartment of Medical Biochemistry and Biophysics, Karolinska InstitutetComputational Medicine Center, Sidney Kimmel Medical College, Thomas Jefferson UniversityDepartment of Medical Biochemistry and Biophysics, Karolinska InstitutetHarry Perkins Institute of Medical Research, QEII Medical Centre and University of Western AustraliaHarry Perkins Institute of Medical Research, QEII Medical Centre and University of Western AustraliaDepartment of Medical Biochemistry and Biophysics, Karolinska InstitutetDepartment of Medical Biochemistry and Biophysics, Karolinska InstitutetDepartment of Medical Biochemistry and Biophysics, Karolinska InstitutetA subset of mitochondrial transcripts is not flanked by tRNAs and thus does not conform to the canonical mode of processing. Here, Clemente et al. demonstrate that phosphatase activity of ANGEL2 is required for correct processing of these transcripts.https://doi.org/10.1038/s41467-022-33368-9 |
| spellingShingle | Paula Clemente Javier Calvo-Garrido Sarah F. Pearce Florian A. Schober Megumi Shigematsu Stefan J. Siira Isabelle Laine Henrik Spåhr Christian Steinmetzger Katja Petzold Yohei Kirino Rolf Wibom Oliver Rackham Aleksandra Filipovska Joanna Rorbach Christoph Freyer Anna Wredenberg ANGEL2 phosphatase activity is required for non-canonical mitochondrial RNA processing Nature Communications |
| title | ANGEL2 phosphatase activity is required for non-canonical mitochondrial RNA processing |
| title_full | ANGEL2 phosphatase activity is required for non-canonical mitochondrial RNA processing |
| title_fullStr | ANGEL2 phosphatase activity is required for non-canonical mitochondrial RNA processing |
| title_full_unstemmed | ANGEL2 phosphatase activity is required for non-canonical mitochondrial RNA processing |
| title_short | ANGEL2 phosphatase activity is required for non-canonical mitochondrial RNA processing |
| title_sort | angel2 phosphatase activity is required for non canonical mitochondrial rna processing |
| url | https://doi.org/10.1038/s41467-022-33368-9 |
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