Continuous-Flow Synthesis of β-Amino Acid Esters by Lipase-Catalyzed Michael Addition of Aromatic Amines

Continuous-Flow Synthesis of β-Amino Acid Esters by Lipase-Catalyzed Michael Addition of Aromatic Amines

A continuous-flow procedure for the synthesis of β-amino acid esters has been developed via lipase-catalyzed Michael reaction of various aromatic amines with acrylates. Lipase TL IM from <i>Thermomyces lanuginosus</i> was first used to catalyze Michael addition reaction of aromatic amine...

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Bibliographic Details
Main Authors: Li-Hua Du, Rui-Jie Long, Miao Xue, Ping-Feng Chen, Meng-Jie Yang, Xi-Ping Luo
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Catalysts
Subjects:
enzymatic synthesis
β-amino acid esters
microreactor
aromatic amines
Michael addition
Online Access:https://www.mdpi.com/2073-4344/10/4/432

Internet

https://www.mdpi.com/2073-4344/10/4/432

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