Prevalence of Cytomegalovirus (CMV) and Epstein-Barr Virus (EBV) Subclinical Infection in Patients with Acute Immune Thrombocytopenic Purpura (ITP)
Background: Immune thrombocytopenic purpura (ITP) is defined as a bleeding disorder in which the number and production of platelets are reduced by the immune system; however, the destruction of peripheral blood platelets also occurs. Although its exact etiology and pathogenesis have not already know...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2021-07-01
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| Series: | International Journal of Hematology-Oncology and Stem Cell Research |
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| Online Access: | https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/1234 |
| _version_ | 1797718227558596608 |
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| author | Farshad Abbasi Gholam Abbas Kaydani Zari Tahannejad Mohsen Nakhaie Ali Aminasnafi Maryam Moradi |
| author_facet | Farshad Abbasi Gholam Abbas Kaydani Zari Tahannejad Mohsen Nakhaie Ali Aminasnafi Maryam Moradi |
| author_sort | Farshad Abbasi |
| collection | DOAJ |
| description | Background: Immune thrombocytopenic purpura (ITP) is defined as a bleeding disorder in which the number and production of platelets are reduced by the immune system; however, the destruction of peripheral blood platelets also occurs. Although its exact etiology and pathogenesis have not already known, several studies have shown that Epstein-Barr virus (EBV) and cytomegalovirus (CMV) are known as possible causative agents of ITP. This investigation aims to evaluate the presence of CMV and EBV in two groups of case and control by polymerase chain reaction (PCR).
Materials and Methods: we considered the presence of CMV and EBV in 48 acute ITP patients and 48 healthy people. Study participants were recruited from Ahvaz Shafa Hospital between 2017 and 2018 and the presence of two viruses was investigated by (PCR).
Results: Out of 48 acute ITP patients, the CMV DNA was detected from the blood of 12 (25%) patients and the EBV DNA from the blood of 2 (4.2%) other patients. Also, only one patient was (2.1%) co-infected with CMV and EBV. In contrast, in 48 healthy subjects, 3 (6.6%) had CMV and none of the control group was infected with EBV.
Conclusion: Due to the presence of both EBV and CMV in the acute ITP patients in Ahvaz, they can be considered as factors in the progression of this disease. Therefore, consideration of the methods of elimination and treatment of these two viruses in these patients may be used as a treatment strategy in ITP patients in the future. |
| first_indexed | 2024-03-12T08:47:49Z |
| format | Article |
| id | doaj.art-72bee1733918466d9ac6480d114ce05b |
| institution | Directory Open Access Journal |
| issn | 2008-2207 |
| language | English |
| last_indexed | 2024-03-12T08:47:49Z |
| publishDate | 2021-07-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | International Journal of Hematology-Oncology and Stem Cell Research |
| spelling | doaj.art-72bee1733918466d9ac6480d114ce05b2023-09-02T16:24:54ZengTehran University of Medical SciencesInternational Journal of Hematology-Oncology and Stem Cell Research2008-22072021-07-0115310.18502/ijhoscr.v15i3.6843Prevalence of Cytomegalovirus (CMV) and Epstein-Barr Virus (EBV) Subclinical Infection in Patients with Acute Immune Thrombocytopenic Purpura (ITP)Farshad Abbasi0Gholam Abbas Kaydani1Zari Tahannejad2Mohsen Nakhaie3Ali Aminasnafi4Maryam Moradi5Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranDepartment of Laboratory Sciences, Paramedical Faculty, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranInfectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranDepartment of Virology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranThalassemia & Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranDepartment of Biostatistics and Epidemiology, School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranBackground: Immune thrombocytopenic purpura (ITP) is defined as a bleeding disorder in which the number and production of platelets are reduced by the immune system; however, the destruction of peripheral blood platelets also occurs. Although its exact etiology and pathogenesis have not already known, several studies have shown that Epstein-Barr virus (EBV) and cytomegalovirus (CMV) are known as possible causative agents of ITP. This investigation aims to evaluate the presence of CMV and EBV in two groups of case and control by polymerase chain reaction (PCR). Materials and Methods: we considered the presence of CMV and EBV in 48 acute ITP patients and 48 healthy people. Study participants were recruited from Ahvaz Shafa Hospital between 2017 and 2018 and the presence of two viruses was investigated by (PCR). Results: Out of 48 acute ITP patients, the CMV DNA was detected from the blood of 12 (25%) patients and the EBV DNA from the blood of 2 (4.2%) other patients. Also, only one patient was (2.1%) co-infected with CMV and EBV. In contrast, in 48 healthy subjects, 3 (6.6%) had CMV and none of the control group was infected with EBV. Conclusion: Due to the presence of both EBV and CMV in the acute ITP patients in Ahvaz, they can be considered as factors in the progression of this disease. Therefore, consideration of the methods of elimination and treatment of these two viruses in these patients may be used as a treatment strategy in ITP patients in the future.https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/1234Immune thrombocytopenic purpura (ITP); Cytomegalovirus (CMV); Epstein-barr virus (EBV) |
| spellingShingle | Farshad Abbasi Gholam Abbas Kaydani Zari Tahannejad Mohsen Nakhaie Ali Aminasnafi Maryam Moradi Prevalence of Cytomegalovirus (CMV) and Epstein-Barr Virus (EBV) Subclinical Infection in Patients with Acute Immune Thrombocytopenic Purpura (ITP) International Journal of Hematology-Oncology and Stem Cell Research Immune thrombocytopenic purpura (ITP); Cytomegalovirus (CMV); Epstein-barr virus (EBV) |
| title | Prevalence of Cytomegalovirus (CMV) and Epstein-Barr Virus (EBV) Subclinical Infection in Patients with Acute Immune Thrombocytopenic Purpura (ITP) |
| title_full | Prevalence of Cytomegalovirus (CMV) and Epstein-Barr Virus (EBV) Subclinical Infection in Patients with Acute Immune Thrombocytopenic Purpura (ITP) |
| title_fullStr | Prevalence of Cytomegalovirus (CMV) and Epstein-Barr Virus (EBV) Subclinical Infection in Patients with Acute Immune Thrombocytopenic Purpura (ITP) |
| title_full_unstemmed | Prevalence of Cytomegalovirus (CMV) and Epstein-Barr Virus (EBV) Subclinical Infection in Patients with Acute Immune Thrombocytopenic Purpura (ITP) |
| title_short | Prevalence of Cytomegalovirus (CMV) and Epstein-Barr Virus (EBV) Subclinical Infection in Patients with Acute Immune Thrombocytopenic Purpura (ITP) |
| title_sort | prevalence of cytomegalovirus cmv and epstein barr virus ebv subclinical infection in patients with acute immune thrombocytopenic purpura itp |
| topic | Immune thrombocytopenic purpura (ITP); Cytomegalovirus (CMV); Epstein-barr virus (EBV) |
| url | https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/1234 |
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