Multidrug resistance-associated ABC transporters – too much of one thing, good for nothing
Overexpression of ATP-binding cassette (ABC) transporters in cancer cells results in multidrug resistance (MDR) which leads to unsuccessful chemotherapy. The most important MDR-associated members of ABC superfamily are ABC B1/P-glycoprotein/MDR1, ABC C1/multidrug resistance associated protein 1 (MRP...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2012-08-01
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| Series: | Biomolecular Concepts |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/bmc-2012-0006 |
| _version_ | 1818670421579399168 |
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| author | Prochazkova Jirina Lanova Martina Pachernik Jiri |
| author_facet | Prochazkova Jirina Lanova Martina Pachernik Jiri |
| author_sort | Prochazkova Jirina |
| collection | DOAJ |
| description | Overexpression of ATP-binding cassette (ABC) transporters in cancer cells results in multidrug resistance (MDR) which leads to unsuccessful chemotherapy. The most important MDR-associated members of ABC superfamily are ABC B1/P-glycoprotein/MDR1, ABC C1/multidrug resistance associated protein 1 (MRP1), and ABC G2/BCRP. This study is not only focused on function, substrates, and localization of these popular proteins but also on other ABC C family members such as ABC C2–6/MRP2-6 and ABC C7/CFTR. Current research is mainly oriented on the cancer-promoting role of these proteins, but important lessons could also be learned from the physiological roles of these proteins or from polymorphisms affecting their function. Thorough knowledge of structure and detailed mechanism of efflux can aid in the discovery of new chemotherapy targets in the future. Although the best way on how to deal with MDR would be to prevent its development, we describe some new promising strategies on how to conquer both inherited and induced MDRs. |
| first_indexed | 2024-12-17T07:07:51Z |
| format | Article |
| id | doaj.art-72c0b5cdc85046acbea178fe406ed1b0 |
| institution | Directory Open Access Journal |
| issn | 1868-5021 1868-503X |
| language | English |
| last_indexed | 2024-12-17T07:07:51Z |
| publishDate | 2012-08-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Biomolecular Concepts |
| spelling | doaj.art-72c0b5cdc85046acbea178fe406ed1b02022-12-21T21:59:07ZengDe GruyterBiomolecular Concepts1868-50211868-503X2012-08-013431933110.1515/bmc-2012-0006Multidrug resistance-associated ABC transporters – too much of one thing, good for nothingProchazkova Jirina0Lanova Martina1Pachernik Jiri2Department of Animal Physiology and Immunology, Faculty of Science, Masaryk University, Kotlarska 2, CZ-611 37 Brno, Czech RepublicDepartment of Animal Physiology and Immunology, Faculty of Science, Masaryk University, Kotlarska 2, CZ-611 37 Brno, Czech RepublicDepartment of Animal Physiology and Immunology, Faculty of Science, Masaryk University, Kotlarska 2, CZ-611 37 Brno, Czech RepublicOverexpression of ATP-binding cassette (ABC) transporters in cancer cells results in multidrug resistance (MDR) which leads to unsuccessful chemotherapy. The most important MDR-associated members of ABC superfamily are ABC B1/P-glycoprotein/MDR1, ABC C1/multidrug resistance associated protein 1 (MRP1), and ABC G2/BCRP. This study is not only focused on function, substrates, and localization of these popular proteins but also on other ABC C family members such as ABC C2–6/MRP2-6 and ABC C7/CFTR. Current research is mainly oriented on the cancer-promoting role of these proteins, but important lessons could also be learned from the physiological roles of these proteins or from polymorphisms affecting their function. Thorough knowledge of structure and detailed mechanism of efflux can aid in the discovery of new chemotherapy targets in the future. Although the best way on how to deal with MDR would be to prevent its development, we describe some new promising strategies on how to conquer both inherited and induced MDRs.https://doi.org/10.1515/bmc-2012-0006abc transportersbarriermultidrug resistancepolymorphismsubstrate |
| spellingShingle | Prochazkova Jirina Lanova Martina Pachernik Jiri Multidrug resistance-associated ABC transporters – too much of one thing, good for nothing Biomolecular Concepts abc transporters barrier multidrug resistance polymorphism substrate |
| title | Multidrug resistance-associated ABC transporters – too much of one thing, good for nothing |
| title_full | Multidrug resistance-associated ABC transporters – too much of one thing, good for nothing |
| title_fullStr | Multidrug resistance-associated ABC transporters – too much of one thing, good for nothing |
| title_full_unstemmed | Multidrug resistance-associated ABC transporters – too much of one thing, good for nothing |
| title_short | Multidrug resistance-associated ABC transporters – too much of one thing, good for nothing |
| title_sort | multidrug resistance associated abc transporters too much of one thing good for nothing |
| topic | abc transporters barrier multidrug resistance polymorphism substrate |
| url | https://doi.org/10.1515/bmc-2012-0006 |
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