Compound C Reducing Interferon Expression by Inhibiting cGAMP Accumulation

Compound C Reducing Interferon Expression by Inhibiting cGAMP Accumulation

Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a major DNA sensor responsible for cytosolic DNA-mediated innate immune response. Inhibition of cGAS may be an effective strategy for treating autoimmune diseases such as Aicardi-Goutieres syndrome and systemic lupus erythematosus. Compound C (also known as...

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Bibliographic Details
Main Authors: Junzhong Lai, Xuan Luo, Shuoran Tian, Xing Zhang, Shanlu Huang, Hanze Wang, Qiumei Li, Shaoli Cai, Qi Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Pharmacology
Subjects:
compound C
dorsomorphin
cGAS
cGAMP
DNA sensing
type I interferon
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00088/full

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