Application of the Extracts of <i>Punica granatum</i> in Oral Cancer: Scoping Review
The <i>Punica granatum</i> L. is an ancient fruit plant native to south-western Asia. It belongs to the Litraceae family and of its genus we have only one other <i>Punica protopunic</i> species. The fruit is rich in polyphenols, whose extract is consumed as a food and is cons...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Dentistry Journal |
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| Online Access: | https://www.mdpi.com/2304-6767/10/12/234 |
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| author | Mario Dioguardi Andrea Ballini Diego Sovereto Francesca Spirito Angela Pia Cazzolla Riccardo Aiuto Vito Crincoli Giorgia Apollonia Caloro Lorenzo Lo Muzio |
| author_facet | Mario Dioguardi Andrea Ballini Diego Sovereto Francesca Spirito Angela Pia Cazzolla Riccardo Aiuto Vito Crincoli Giorgia Apollonia Caloro Lorenzo Lo Muzio |
| author_sort | Mario Dioguardi |
| collection | DOAJ |
| description | The <i>Punica granatum</i> L. is an ancient fruit plant native to south-western Asia. It belongs to the Litraceae family and of its genus we have only one other <i>Punica protopunic</i> species. The fruit is rich in polyphenols, whose extract is consumed as a food and is considered safe. In medicine, it is used for its antioxidant properties; it has a rich component of tannic polyphenols among which the most bioactive are: punicalagin (flavonoids) and anthocyanins (delphinidin, cyanidin, pelargonidin), which are found mainly in the skins and in the pericarp; however, all the parts of the <i>Punica granatum</i> are used for therapeutic purposes as anti-inflammatories and analgesics and in diabetes and cardio-vascular disease. <i>Punica granatum</i> extracts also show interesting anticancer activities in influencing tumorgenesis and angiogenesis and cell transformation and proliferation. The purpose of this scoping review is to summarize all the scientific evidence on the possible applications of <i>Punica granatum</i> extracts in the treatment and prevention of oral cavity tumors to investigate the anticancer properties of the active ingredients extracted from <i>Punica granatum.</i> Methods: The scoping review was carried out following the PRISMA-ScR checklist; the search was performed on three databases (Scopus, Science direct and PubMed) and one registry (Cochrane library). Results: The search produced a number of bibliographic sources equal to 11,403; with the removal of duplicates, 670 potentially admissible articles were obtained, from 24 of which only 7 in vitro studies on OSCC cell lines were included. Conclusions: From the preliminary data on the cellular lines of OSCC, it emerges that for oral cancer there are conditions for which the extracts of <i>Punic granatum</i> are effective at least from a prevention perspective. |
| first_indexed | 2024-03-09T17:09:22Z |
| format | Article |
| id | doaj.art-72c645f3f4414ee38420976e1f4821c7 |
| institution | Directory Open Access Journal |
| issn | 2304-6767 |
| language | English |
| last_indexed | 2024-03-09T17:09:22Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Dentistry Journal |
| spelling | doaj.art-72c645f3f4414ee38420976e1f4821c72023-11-24T14:14:18ZengMDPI AGDentistry Journal2304-67672022-12-01101223410.3390/dj10120234Application of the Extracts of <i>Punica granatum</i> in Oral Cancer: Scoping ReviewMario Dioguardi0Andrea Ballini1Diego Sovereto2Francesca Spirito3Angela Pia Cazzolla4Riccardo Aiuto5Vito Crincoli6Giorgia Apollonia Caloro7Lorenzo Lo Muzio8Department of Clinical and Experimental Medicine, University of Foggia, Via Rovelli 50, 71122 Foggia, ItalyDepartment of Precision Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Clinical and Experimental Medicine, University of Foggia, Via Rovelli 50, 71122 Foggia, ItalyDepartment of Clinical and Experimental Medicine, University of Foggia, Via Rovelli 50, 71122 Foggia, ItalyDepartment of Clinical and Experimental Medicine, University of Foggia, Via Rovelli 50, 71122 Foggia, ItalyDepartment of Biomedical, Surgical, and Dental Science, University of Milan, 20122 Milan, ItalyDepartment of Basic Medical Sciences, Neurosciences and Sensory Organs, Division of Complex Operating Unit of Dentistry, “Aldo Moro” University of Bari, Piazza G. Cesare 11, 70124 Bari, ItalyUnità Operativa Nefrologia e Dialisi, Presidio Ospedaliero Scorrano, ASL (Azienda Sanitaria Locale) Lecce, Via Giuseppina Delli Ponti, 73020 Scorrano, ItalyDepartment of Clinical and Experimental Medicine, University of Foggia, Via Rovelli 50, 71122 Foggia, ItalyThe <i>Punica granatum</i> L. is an ancient fruit plant native to south-western Asia. It belongs to the Litraceae family and of its genus we have only one other <i>Punica protopunic</i> species. The fruit is rich in polyphenols, whose extract is consumed as a food and is considered safe. In medicine, it is used for its antioxidant properties; it has a rich component of tannic polyphenols among which the most bioactive are: punicalagin (flavonoids) and anthocyanins (delphinidin, cyanidin, pelargonidin), which are found mainly in the skins and in the pericarp; however, all the parts of the <i>Punica granatum</i> are used for therapeutic purposes as anti-inflammatories and analgesics and in diabetes and cardio-vascular disease. <i>Punica granatum</i> extracts also show interesting anticancer activities in influencing tumorgenesis and angiogenesis and cell transformation and proliferation. The purpose of this scoping review is to summarize all the scientific evidence on the possible applications of <i>Punica granatum</i> extracts in the treatment and prevention of oral cavity tumors to investigate the anticancer properties of the active ingredients extracted from <i>Punica granatum.</i> Methods: The scoping review was carried out following the PRISMA-ScR checklist; the search was performed on three databases (Scopus, Science direct and PubMed) and one registry (Cochrane library). Results: The search produced a number of bibliographic sources equal to 11,403; with the removal of duplicates, 670 potentially admissible articles were obtained, from 24 of which only 7 in vitro studies on OSCC cell lines were included. Conclusions: From the preliminary data on the cellular lines of OSCC, it emerges that for oral cancer there are conditions for which the extracts of <i>Punic granatum</i> are effective at least from a prevention perspective.https://www.mdpi.com/2304-6767/10/12/234oral cancer<i>Punica granatum</i>pomegranateOSCC |
| spellingShingle | Mario Dioguardi Andrea Ballini Diego Sovereto Francesca Spirito Angela Pia Cazzolla Riccardo Aiuto Vito Crincoli Giorgia Apollonia Caloro Lorenzo Lo Muzio Application of the Extracts of <i>Punica granatum</i> in Oral Cancer: Scoping Review Dentistry Journal oral cancer <i>Punica granatum</i> pomegranate OSCC |
| title | Application of the Extracts of <i>Punica granatum</i> in Oral Cancer: Scoping Review |
| title_full | Application of the Extracts of <i>Punica granatum</i> in Oral Cancer: Scoping Review |
| title_fullStr | Application of the Extracts of <i>Punica granatum</i> in Oral Cancer: Scoping Review |
| title_full_unstemmed | Application of the Extracts of <i>Punica granatum</i> in Oral Cancer: Scoping Review |
| title_short | Application of the Extracts of <i>Punica granatum</i> in Oral Cancer: Scoping Review |
| title_sort | application of the extracts of i punica granatum i in oral cancer scoping review |
| topic | oral cancer <i>Punica granatum</i> pomegranate OSCC |
| url | https://www.mdpi.com/2304-6767/10/12/234 |
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