Rheumatoid polyarthritis suspected in an HIV patient with scleritis, peripheral ulcerative keratitis, and anterior uveitis
Christelle Domngang Noche,1 Madeleine Singwé-Ngandeu,2 Assumpta Lucienne Bella2 1Université des Montagnes, Yaoundé, Cameroon; 2Université de Yaoundé 1, Yaoundé, Cameroon Introduction: Scleritis and peripheral ulcerative keratitis are...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2016-02-01
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| Series: | International Medical Case Reports Journal |
| Subjects: | |
| Online Access: | https://www.dovepress.com/rheumatoid-polyarthritis-suspected-in-an-hiv-patient-with-scleritis-pe-peer-reviewed-article-IMCRJ |
| _version_ | 1818016459685625856 |
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| author | Domngang Noche C Singwé-Ngandeu M Bella AL |
| author_facet | Domngang Noche C Singwé-Ngandeu M Bella AL |
| author_sort | Domngang Noche C |
| collection | DOAJ |
| description | Christelle Domngang Noche,1 Madeleine Singwé-Ngandeu,2 Assumpta Lucienne Bella2 1Université des Montagnes, Yaoundé, Cameroon; 2Université de Yaoundé 1, Yaoundé, Cameroon Introduction: Scleritis and peripheral ulcerative keratitis are ocular manifestations found in many inflammations and infections. Therefore, their association should prompt a search for inflammatory or infectious causes that may be life-threatening, especially in the context of AIDS due to HIV infection. Findings: We report the case of a 37-year-old female, first seen in 2011 with a nodular scleritis in the right eye and a peripheral ulcerative keratitis, a necrotizing scleritis, and a granulomatous anterior uveitis in the left eye, in the context of chronic polyarthropathies that had evolved over 6 months. The patient was diagnosed with AIDS (HIV) in 2008 and was on antiretroviral therapy for the past 2 years. Ophthalmic workup was negative for opportunistic infections and potential causes of scleritis and peripheral ulcerative keratitis, and the patient was unresponsive to topical antibacterial and anti-inflammatory treatment. Ocular lesion resolution and articular swelling improvement was observed less than 6 weeks after sulfasalazine treatment. Based on American College of Rheumatology/European League Against Rheumatism classification criteria, and considering the good response to the treatment (sulfasalazine), diagnosis of rheumatoid arthritis was made in the absence of confirmatory lab tests results. Conclusion: In the context of ocular manifestations associated with polyarthropathies, coexisting pathologies should be considered. Diagnostic workup of chronic inflammatory rheumatism should be carried out, even in the context of HIV/AIDS. Keywords: scleritis, peripheral ulcerative keratitis, anterior uveitis, rheumatoid arthritis, HIV/AIDS |
| first_indexed | 2024-04-14T07:13:33Z |
| format | Article |
| id | doaj.art-72c7a3fb18cf45c2a46b191584c102dc |
| institution | Directory Open Access Journal |
| issn | 1179-142X |
| language | English |
| last_indexed | 2024-04-14T07:13:33Z |
| publishDate | 2016-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Medical Case Reports Journal |
| spelling | doaj.art-72c7a3fb18cf45c2a46b191584c102dc2022-12-22T02:06:22ZengDove Medical PressInternational Medical Case Reports Journal1179-142X2016-02-012016Issue 1192425495Rheumatoid polyarthritis suspected in an HIV patient with scleritis, peripheral ulcerative keratitis, and anterior uveitisDomngang Noche CSingwé-Ngandeu MBella ALChristelle Domngang Noche,1 Madeleine Singwé-Ngandeu,2 Assumpta Lucienne Bella2 1Université des Montagnes, Yaoundé, Cameroon; 2Université de Yaoundé 1, Yaoundé, Cameroon Introduction: Scleritis and peripheral ulcerative keratitis are ocular manifestations found in many inflammations and infections. Therefore, their association should prompt a search for inflammatory or infectious causes that may be life-threatening, especially in the context of AIDS due to HIV infection. Findings: We report the case of a 37-year-old female, first seen in 2011 with a nodular scleritis in the right eye and a peripheral ulcerative keratitis, a necrotizing scleritis, and a granulomatous anterior uveitis in the left eye, in the context of chronic polyarthropathies that had evolved over 6 months. The patient was diagnosed with AIDS (HIV) in 2008 and was on antiretroviral therapy for the past 2 years. Ophthalmic workup was negative for opportunistic infections and potential causes of scleritis and peripheral ulcerative keratitis, and the patient was unresponsive to topical antibacterial and anti-inflammatory treatment. Ocular lesion resolution and articular swelling improvement was observed less than 6 weeks after sulfasalazine treatment. Based on American College of Rheumatology/European League Against Rheumatism classification criteria, and considering the good response to the treatment (sulfasalazine), diagnosis of rheumatoid arthritis was made in the absence of confirmatory lab tests results. Conclusion: In the context of ocular manifestations associated with polyarthropathies, coexisting pathologies should be considered. Diagnostic workup of chronic inflammatory rheumatism should be carried out, even in the context of HIV/AIDS. Keywords: scleritis, peripheral ulcerative keratitis, anterior uveitis, rheumatoid arthritis, HIV/AIDShttps://www.dovepress.com/rheumatoid-polyarthritis-suspected-in-an-hiv-patient-with-scleritis-pe-peer-reviewed-article-IMCRJScleritisperipheral ulcerative keratitisanterior uveitisrheumatoid arthritisHIV. |
| spellingShingle | Domngang Noche C Singwé-Ngandeu M Bella AL Rheumatoid polyarthritis suspected in an HIV patient with scleritis, peripheral ulcerative keratitis, and anterior uveitis International Medical Case Reports Journal Scleritis peripheral ulcerative keratitis anterior uveitis rheumatoid arthritis HIV. |
| title | Rheumatoid polyarthritis suspected in an HIV patient with scleritis, peripheral ulcerative keratitis, and anterior uveitis |
| title_full | Rheumatoid polyarthritis suspected in an HIV patient with scleritis, peripheral ulcerative keratitis, and anterior uveitis |
| title_fullStr | Rheumatoid polyarthritis suspected in an HIV patient with scleritis, peripheral ulcerative keratitis, and anterior uveitis |
| title_full_unstemmed | Rheumatoid polyarthritis suspected in an HIV patient with scleritis, peripheral ulcerative keratitis, and anterior uveitis |
| title_short | Rheumatoid polyarthritis suspected in an HIV patient with scleritis, peripheral ulcerative keratitis, and anterior uveitis |
| title_sort | rheumatoid polyarthritis suspected in an hiv patient with scleritis peripheral ulcerative keratitis and anterior uveitis |
| topic | Scleritis peripheral ulcerative keratitis anterior uveitis rheumatoid arthritis HIV. |
| url | https://www.dovepress.com/rheumatoid-polyarthritis-suspected-in-an-hiv-patient-with-scleritis-pe-peer-reviewed-article-IMCRJ |
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