Application Simplex Lattice Design on Optimizing Formula of Ketoprofen Matrix Patch Transdermal
Ketoprofen is a propionic acid derivative that has anti-inflammatory, analgesic, and antipyretic activity. Transdermal patch dosage form is the right choice for ketoprofen in an effort to minimize side effects, improving patient compliance and ensure the achievement of therapeutic targets. This s...
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| Format: | Article |
| Language: | English |
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LPPT Universitas Gadjah Mada
2019-07-01
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| Series: | Journal of Food and Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | https://jurnal.ugm.ac.id/v3/JFPS/article/view/722 |
| _version_ | 1827631345679990784 |
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| author | Eka Indra Setyawan Akhmad Kharis Nugroho Achmad Fudholi |
| author_facet | Eka Indra Setyawan Akhmad Kharis Nugroho Achmad Fudholi |
| author_sort | Eka Indra Setyawan |
| collection | DOAJ |
| description | Ketoprofen is a propionic acid derivative that has anti-inflammatory, analgesic, and antipyretic activity. Transdermal patch dosage form is the right choice for ketoprofen in an effort to minimize side effects, improving patient compliance and ensure the achievement of therapeutic targets.
This study aimed to optimize the formulation of ketoprofen matrix patch transdermal. The optimizing process was analyzed by simplex lattice model. Determination of the level of ketoprofen released was carried out by spectrophotometer UV-Vis. Interpretation of the dissolution profile can be seen visually fit between the model constructed from the zero-order approximation, first-order, Higuchi, Korsmeyer-Peppas, Weibull, Hixson-Crowell and Baker-Lonsdale. The results provide information that a combination of MC and HPMC polymers have a significant influence on increasing the patch weight, patch thickness, loss on drying and dissolution efficiency and insignificant effect against folding endurance. The optimal formula is generated by a combination of HPMC:MC (0.1:0.9) and produces a patch matrix with weight, thickness, drying loss, and DE were 0.68 g, 0.36 mm, 12.42%, and 23.21%, respectively. The release kinetic of ketoprofen followed Korsmeyer-Peppas model through the mechanism of non-Fickian diffusion. |
| first_indexed | 2024-03-09T14:20:39Z |
| format | Article |
| id | doaj.art-72c91a8fa58d4c00923452b16f0cfbd5 |
| institution | Directory Open Access Journal |
| issn | 2089-7200 2339-0948 |
| language | English |
| last_indexed | 2024-03-09T14:20:39Z |
| publishDate | 2019-07-01 |
| publisher | LPPT Universitas Gadjah Mada |
| record_format | Article |
| series | Journal of Food and Pharmaceutical Sciences |
| spelling | doaj.art-72c91a8fa58d4c00923452b16f0cfbd52023-11-28T15:06:05ZengLPPT Universitas Gadjah MadaJournal of Food and Pharmaceutical Sciences2089-72002339-09482019-07-0110711610.22146/jfps.722722Application Simplex Lattice Design on Optimizing Formula of Ketoprofen Matrix Patch TransdermalEka Indra Setyawan0Akhmad Kharis Nugroho1Achmad Fudholi2Faculty of Mathematics and Natural Science, Udayana University, Bali, Indonesia Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, IndonesiaFaculty of Pharmacy, Gadjah Mada University, Yogyakarta, IndonesiaKetoprofen is a propionic acid derivative that has anti-inflammatory, analgesic, and antipyretic activity. Transdermal patch dosage form is the right choice for ketoprofen in an effort to minimize side effects, improving patient compliance and ensure the achievement of therapeutic targets. This study aimed to optimize the formulation of ketoprofen matrix patch transdermal. The optimizing process was analyzed by simplex lattice model. Determination of the level of ketoprofen released was carried out by spectrophotometer UV-Vis. Interpretation of the dissolution profile can be seen visually fit between the model constructed from the zero-order approximation, first-order, Higuchi, Korsmeyer-Peppas, Weibull, Hixson-Crowell and Baker-Lonsdale. The results provide information that a combination of MC and HPMC polymers have a significant influence on increasing the patch weight, patch thickness, loss on drying and dissolution efficiency and insignificant effect against folding endurance. The optimal formula is generated by a combination of HPMC:MC (0.1:0.9) and produces a patch matrix with weight, thickness, drying loss, and DE were 0.68 g, 0.36 mm, 12.42%, and 23.21%, respectively. The release kinetic of ketoprofen followed Korsmeyer-Peppas model through the mechanism of non-Fickian diffusion.https://jurnal.ugm.ac.id/v3/JFPS/article/view/722transdermal, ketoprofen, optimizing, release kinetic |
| spellingShingle | Eka Indra Setyawan Akhmad Kharis Nugroho Achmad Fudholi Application Simplex Lattice Design on Optimizing Formula of Ketoprofen Matrix Patch Transdermal Journal of Food and Pharmaceutical Sciences transdermal, ketoprofen, optimizing, release kinetic |
| title | Application Simplex Lattice Design on Optimizing Formula of Ketoprofen Matrix Patch Transdermal |
| title_full | Application Simplex Lattice Design on Optimizing Formula of Ketoprofen Matrix Patch Transdermal |
| title_fullStr | Application Simplex Lattice Design on Optimizing Formula of Ketoprofen Matrix Patch Transdermal |
| title_full_unstemmed | Application Simplex Lattice Design on Optimizing Formula of Ketoprofen Matrix Patch Transdermal |
| title_short | Application Simplex Lattice Design on Optimizing Formula of Ketoprofen Matrix Patch Transdermal |
| title_sort | application simplex lattice design on optimizing formula of ketoprofen matrix patch transdermal |
| topic | transdermal, ketoprofen, optimizing, release kinetic |
| url | https://jurnal.ugm.ac.id/v3/JFPS/article/view/722 |
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