Type I IFNs Are Required to Promote Central Nervous System Immune Surveillance through the Recruitment of Inflammatory Monocytes upon Systemic Inflammation

Type I IFNs Are Required to Promote Central Nervous System Immune Surveillance through the Recruitment of Inflammatory Monocytes upon Systemic Inflammation

Brain-resident microglia and peripheral migratory leukocytes play essential roles in shaping the immune response in the central nervous system. These cells activate and migrate in response to chemokines produced during active immune responses and may contribute to the progression of neuroinflammatio...

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Bibliographic Details
Main Authors: Javier María Peralta Ramos, Claudio Bussi, Emilia Andrea Gaviglio, Daniela Soledad Arroyo, Natalia Soledad Baez, Maria Cecilia Rodriguez-Galan, Pablo Iribarren
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Immunology
Subjects:
microglia
inflammatory monocytes
inflammation
lipopolysaccharide
interferons
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01666/full

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