Benzodiazepine Use and the Risk of Dementia in the Elderly Population: An Umbrella Review of Meta-Analyses
The prevalence of dementia among the elderly is high, and it is the leading cause of death globally. However, the relationship between benzodiazepine use and dementia risk has produced inconsistent results, necessitating an updated review of the evidence. To address this, we conducted an umbrella re...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/13/10/1485 |
| _version_ | 1797573303757438976 |
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| author | Chieh-Chen Wu Mao-Hung Liao Chun-Hsien Su Tahmina Nasrin Poly Ming-Chin Lin |
| author_facet | Chieh-Chen Wu Mao-Hung Liao Chun-Hsien Su Tahmina Nasrin Poly Ming-Chin Lin |
| author_sort | Chieh-Chen Wu |
| collection | DOAJ |
| description | The prevalence of dementia among the elderly is high, and it is the leading cause of death globally. However, the relationship between benzodiazepine use and dementia risk has produced inconsistent results, necessitating an updated review of the evidence. To address this, we conducted an umbrella review of meta-analyses to summarize the available evidence on the association between benzodiazepine use and dementia risk and evaluate its credibility. We systematically evaluated the meta-analyses of observational studies that examined the connection between benzodiazepine use and dementia risk. For each meta-analysis, we collected the overall effect size, heterogeneity, risk of bias, and year of the most recent article and graded the evidence based on pre-specified criteria. We also used AMSTAR, a measurement tool to evaluate systematic reviews, to assess the methodological quality of each study. Our review included five meta-analyses encompassing 30 studies, and the effect size of the association between benzodiazepine use and dementia risk ranged from 1.38 to 1.78. Nonetheless, the evidence supporting this relationship was weak, and the methodological quality of the studies included was low. In conclusion, our findings revealed limited evidence of a link between benzodiazepine use and dementia risk, and more research is required to determine a causal connection. Physicians should only prescribe benzodiazepine for appropriate indications. |
| first_indexed | 2024-03-10T21:07:54Z |
| format | Article |
| id | doaj.art-72cc5392ca6a4852af111594f744b048 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-10T21:07:54Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-72cc5392ca6a4852af111594f744b0482023-11-19T17:02:18ZengMDPI AGJournal of Personalized Medicine2075-44262023-10-011310148510.3390/jpm13101485Benzodiazepine Use and the Risk of Dementia in the Elderly Population: An Umbrella Review of Meta-AnalysesChieh-Chen Wu0Mao-Hung Liao1Chun-Hsien Su2Tahmina Nasrin Poly3Ming-Chin Lin4Department of Exercise and Health Promotion, College of Kinesiology and Health, Chinese Culture University, Taipei 111396, TaiwanSuperintendent Office, Yonghe Cardinal Tien Hospital, New Taipei City 23148, TaiwanDepartment of Exercise and Health Promotion, College of Kinesiology and Health, Chinese Culture University, Taipei 111396, TaiwanGraduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei 110, TaiwanGraduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei 110, TaiwanThe prevalence of dementia among the elderly is high, and it is the leading cause of death globally. However, the relationship between benzodiazepine use and dementia risk has produced inconsistent results, necessitating an updated review of the evidence. To address this, we conducted an umbrella review of meta-analyses to summarize the available evidence on the association between benzodiazepine use and dementia risk and evaluate its credibility. We systematically evaluated the meta-analyses of observational studies that examined the connection between benzodiazepine use and dementia risk. For each meta-analysis, we collected the overall effect size, heterogeneity, risk of bias, and year of the most recent article and graded the evidence based on pre-specified criteria. We also used AMSTAR, a measurement tool to evaluate systematic reviews, to assess the methodological quality of each study. Our review included five meta-analyses encompassing 30 studies, and the effect size of the association between benzodiazepine use and dementia risk ranged from 1.38 to 1.78. Nonetheless, the evidence supporting this relationship was weak, and the methodological quality of the studies included was low. In conclusion, our findings revealed limited evidence of a link between benzodiazepine use and dementia risk, and more research is required to determine a causal connection. Physicians should only prescribe benzodiazepine for appropriate indications.https://www.mdpi.com/2075-4426/13/10/1485benzodiazepinedementiaAlzheimer’s diseasemeta-analysis |
| spellingShingle | Chieh-Chen Wu Mao-Hung Liao Chun-Hsien Su Tahmina Nasrin Poly Ming-Chin Lin Benzodiazepine Use and the Risk of Dementia in the Elderly Population: An Umbrella Review of Meta-Analyses Journal of Personalized Medicine benzodiazepine dementia Alzheimer’s disease meta-analysis |
| title | Benzodiazepine Use and the Risk of Dementia in the Elderly Population: An Umbrella Review of Meta-Analyses |
| title_full | Benzodiazepine Use and the Risk of Dementia in the Elderly Population: An Umbrella Review of Meta-Analyses |
| title_fullStr | Benzodiazepine Use and the Risk of Dementia in the Elderly Population: An Umbrella Review of Meta-Analyses |
| title_full_unstemmed | Benzodiazepine Use and the Risk of Dementia in the Elderly Population: An Umbrella Review of Meta-Analyses |
| title_short | Benzodiazepine Use and the Risk of Dementia in the Elderly Population: An Umbrella Review of Meta-Analyses |
| title_sort | benzodiazepine use and the risk of dementia in the elderly population an umbrella review of meta analyses |
| topic | benzodiazepine dementia Alzheimer’s disease meta-analysis |
| url | https://www.mdpi.com/2075-4426/13/10/1485 |
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