PD-L1 Expression in Cutaneous Angiosarcomas: A Systematic Review with Meta-Analysis
Cutaneous angiosarcoma (CAS) is the most common type of angiosarcoma that predominantly affects older Caucasians. The outcomes of immunotherapy in CAS are currently under investigation in relation to the expression of programmed death ligand 1 (PD-L1) and other biomarkers. We performed a systematic...
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MDPI AG
2023-05-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/30/5/388 |
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| author | Renato Lobrano Panagiotis Paliogiannis Angelo Zinellu Giuseppe Palmieri Ivana Persico Arduino A. Mangoni Antonio Cossu |
| author_facet | Renato Lobrano Panagiotis Paliogiannis Angelo Zinellu Giuseppe Palmieri Ivana Persico Arduino A. Mangoni Antonio Cossu |
| author_sort | Renato Lobrano |
| collection | DOAJ |
| description | Cutaneous angiosarcoma (CAS) is the most common type of angiosarcoma that predominantly affects older Caucasians. The outcomes of immunotherapy in CAS are currently under investigation in relation to the expression of programmed death ligand 1 (PD-L1) and other biomarkers. We performed a systematic review and metanalysis of data from the current literature reporting on PD-L1 immunohistochemistry expression. A systematic search of publications in the electronic databases PubMed, Web of Science, and Scopus was conducted using the following terms: “PD-L1” and “angiosarcomas”. A total of ten studies reporting on 279 cases were identified and included in the meta-analysis. The pooled prevalence of PD-L1 expression in CAS was 54% (95% CI 36–71%), with high heterogeneity (I<sup>2</sup> = 84.81%, <i>p</i> < 0.001). In sub-group analysis, the proportion of PD-L1 expression in CAS was significantly (<i>p</i> = 0.049) lower in Asian studies (ES = 35%, 95% CI 28–42%, I<sup>2</sup> = 0.0%, <i>p</i> = 0.46) than in European studies (ES = 71%, 95% CI 51–89%, I<sup>2</sup> = 48.91%, <i>p</i> = 0.12). |
| first_indexed | 2024-03-11T03:49:44Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-11T03:49:44Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-72ccb13f273c43259e9449125b905e2e2023-11-18T01:02:09ZengMDPI AGCurrent Oncology1198-00521718-77292023-05-013055135514410.3390/curroncol30050388PD-L1 Expression in Cutaneous Angiosarcomas: A Systematic Review with Meta-AnalysisRenato Lobrano0Panagiotis Paliogiannis1Angelo Zinellu2Giuseppe Palmieri3Ivana Persico4Arduino A. Mangoni5Antonio Cossu6Anatomic Pathology and Histology, University Hospital (AOU) of Sassari, Via Matteotti 60, 07100 Sassari, ItalyAnatomic Pathology and Histology, University Hospital (AOU) of Sassari, Via Matteotti 60, 07100 Sassari, ItalyDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43, 07100 Sassari, ItalyDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43, 07100 Sassari, ItalyInstitute of Genetic and Biomolecular Research, National Research Council (CNR), Traversa La Crucca 3, 07100 Sassari, ItalyDiscipline of Clinical Pharmacology, College of Medicine and Public Health, Flinders University, Sturt Road, Bedford Park, Adelaide, SA 5042, AustraliaAnatomic Pathology and Histology, University Hospital (AOU) of Sassari, Via Matteotti 60, 07100 Sassari, ItalyCutaneous angiosarcoma (CAS) is the most common type of angiosarcoma that predominantly affects older Caucasians. The outcomes of immunotherapy in CAS are currently under investigation in relation to the expression of programmed death ligand 1 (PD-L1) and other biomarkers. We performed a systematic review and metanalysis of data from the current literature reporting on PD-L1 immunohistochemistry expression. A systematic search of publications in the electronic databases PubMed, Web of Science, and Scopus was conducted using the following terms: “PD-L1” and “angiosarcomas”. A total of ten studies reporting on 279 cases were identified and included in the meta-analysis. The pooled prevalence of PD-L1 expression in CAS was 54% (95% CI 36–71%), with high heterogeneity (I<sup>2</sup> = 84.81%, <i>p</i> < 0.001). In sub-group analysis, the proportion of PD-L1 expression in CAS was significantly (<i>p</i> = 0.049) lower in Asian studies (ES = 35%, 95% CI 28–42%, I<sup>2</sup> = 0.0%, <i>p</i> = 0.46) than in European studies (ES = 71%, 95% CI 51–89%, I<sup>2</sup> = 48.91%, <i>p</i> = 0.12).https://www.mdpi.com/1718-7729/30/5/388skincancercutaneous angiosarcomasPD-L1immunohistochemistryimmunotherapy |
| spellingShingle | Renato Lobrano Panagiotis Paliogiannis Angelo Zinellu Giuseppe Palmieri Ivana Persico Arduino A. Mangoni Antonio Cossu PD-L1 Expression in Cutaneous Angiosarcomas: A Systematic Review with Meta-Analysis Current Oncology skin cancer cutaneous angiosarcomas PD-L1 immunohistochemistry immunotherapy |
| title | PD-L1 Expression in Cutaneous Angiosarcomas: A Systematic Review with Meta-Analysis |
| title_full | PD-L1 Expression in Cutaneous Angiosarcomas: A Systematic Review with Meta-Analysis |
| title_fullStr | PD-L1 Expression in Cutaneous Angiosarcomas: A Systematic Review with Meta-Analysis |
| title_full_unstemmed | PD-L1 Expression in Cutaneous Angiosarcomas: A Systematic Review with Meta-Analysis |
| title_short | PD-L1 Expression in Cutaneous Angiosarcomas: A Systematic Review with Meta-Analysis |
| title_sort | pd l1 expression in cutaneous angiosarcomas a systematic review with meta analysis |
| topic | skin cancer cutaneous angiosarcomas PD-L1 immunohistochemistry immunotherapy |
| url | https://www.mdpi.com/1718-7729/30/5/388 |
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