Research on Integrated 3D Printing of Microfluidic Chips
Microfluidic chips have the advantages of miniaturization, integration, and portability, and are widely used in the early diagnosis of major diseases, personalized medical treatment, environmental detection, health quarantine, and other fields. The existing microfluidic chip manufacturing process is...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-06-01
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| Series: | Micromachines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-666X/14/7/1302 |
| _version_ | 1797588290626387968 |
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| author | Chuang Wu Jiju Sun Binfeng Yin |
| author_facet | Chuang Wu Jiju Sun Binfeng Yin |
| author_sort | Chuang Wu |
| collection | DOAJ |
| description | Microfluidic chips have the advantages of miniaturization, integration, and portability, and are widely used in the early diagnosis of major diseases, personalized medical treatment, environmental detection, health quarantine, and other fields. The existing microfluidic chip manufacturing process is difficult to operate because of complex three-dimensional channels, complicated manufacturing steps, limited printing materials, the difficulty of operating the bonding process, and the need to purchase expensive new equipment. In this paper, an integrated molding method for microfluidic chips that integrates 3D printing and polymer dissolution technology is proposed. First, the channel mold of poly(vinyl alcohol) (PVA) or high impact polystyrene (HIPS) is dissolved to complete the manufacturing of the microfluidic chip channel. The integrated 3D-forming method of microfluidic chips proposed in this paper can manufacture microchannels inside the microfluidic chip, avoid the bonding process, and eliminate the need for rapid alignment of microchannels, material modification, and other operations, thus improving the stability of the process. Finally, by comparing the microchannels made by PVA and HIPS, it is concluded that the quality of the microchannels made by HIPS is obviously better than that made by PVA. This paper provides a new idea for the fabrication of microfluidic chips and the application of HIPS. |
| first_indexed | 2024-03-11T00:49:52Z |
| format | Article |
| id | doaj.art-72ce13d114f54820a05d419c066e2c6e |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-03-11T00:49:52Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-72ce13d114f54820a05d419c066e2c6e2023-11-18T20:31:31ZengMDPI AGMicromachines2072-666X2023-06-01147130210.3390/mi14071302Research on Integrated 3D Printing of Microfluidic ChipsChuang Wu0Jiju Sun1Binfeng Yin2School of mechanical engineering, Yangzhou University, No. 196 West Huang Road, Yangzhou 225127, ChinaSchool of mechanical engineering, Yangzhou University, No. 196 West Huang Road, Yangzhou 225127, ChinaSchool of mechanical engineering, Yangzhou University, No. 196 West Huang Road, Yangzhou 225127, ChinaMicrofluidic chips have the advantages of miniaturization, integration, and portability, and are widely used in the early diagnosis of major diseases, personalized medical treatment, environmental detection, health quarantine, and other fields. The existing microfluidic chip manufacturing process is difficult to operate because of complex three-dimensional channels, complicated manufacturing steps, limited printing materials, the difficulty of operating the bonding process, and the need to purchase expensive new equipment. In this paper, an integrated molding method for microfluidic chips that integrates 3D printing and polymer dissolution technology is proposed. First, the channel mold of poly(vinyl alcohol) (PVA) or high impact polystyrene (HIPS) is dissolved to complete the manufacturing of the microfluidic chip channel. The integrated 3D-forming method of microfluidic chips proposed in this paper can manufacture microchannels inside the microfluidic chip, avoid the bonding process, and eliminate the need for rapid alignment of microchannels, material modification, and other operations, thus improving the stability of the process. Finally, by comparing the microchannels made by PVA and HIPS, it is concluded that the quality of the microchannels made by HIPS is obviously better than that made by PVA. This paper provides a new idea for the fabrication of microfluidic chips and the application of HIPS.https://www.mdpi.com/2072-666X/14/7/1302microfluidic3D printingbonding methodHIPSPDMS |
| spellingShingle | Chuang Wu Jiju Sun Binfeng Yin Research on Integrated 3D Printing of Microfluidic Chips Micromachines microfluidic 3D printing bonding method HIPS PDMS |
| title | Research on Integrated 3D Printing of Microfluidic Chips |
| title_full | Research on Integrated 3D Printing of Microfluidic Chips |
| title_fullStr | Research on Integrated 3D Printing of Microfluidic Chips |
| title_full_unstemmed | Research on Integrated 3D Printing of Microfluidic Chips |
| title_short | Research on Integrated 3D Printing of Microfluidic Chips |
| title_sort | research on integrated 3d printing of microfluidic chips |
| topic | microfluidic 3D printing bonding method HIPS PDMS |
| url | https://www.mdpi.com/2072-666X/14/7/1302 |
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