Resistance to Platinum-Containing Chemotherapy in Testicular Germ Cell Tumors Is Associated with Downregulation of the Protein Kinase SRPK1

Resistance to Platinum-Containing Chemotherapy in Testicular Germ Cell Tumors Is Associated with Downregulation of the Protein Kinase SRPK1

Male germ cell tumors (GCTs) are extremely sensitive to platinum-containing chemotherapy, with only 10% of patients showing therapy resistance. However, the biological basis of the high curability of disseminated GCTs by chemotherapy is still unknown. Recently, we demonstrated that the mammalian ser...

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Bibliographic Details
Main Authors: Paul W. Schenk, Hans Stoop, Carsten Bokemeyer, Frank Mayer, Gerrit Stoter, J. Wolter Oosterhuis, Erik Wiemer, Leendert H.J. Looijenga, Kees Nooter
Format: Article
Language:English
Published: Elsevier 2004-07-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Chemotherapy resistance
germ cell tumors
chemotherapy sensitivity
protein kinase SRPK1
immunohistochemistry
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558604800770

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