The Brain Research Hotspot Database (BRHD): A Panoramic Database of the Latest Hotspots in Brain Research
Brain science, an emerging, dynamic, multidisciplinary basic research field, is generating numerous valuable data. However, there are still several obstacles for the utilization of these data, such as data fragmentation, heterogeneity, availability, and annotation divergence. Thus, to overcome these...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/12/5/638 |
| _version_ | 1827669975304765440 |
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| author | Pin Chen Xue Lin Anna Liu Jian Li |
| author_facet | Pin Chen Xue Lin Anna Liu Jian Li |
| author_sort | Pin Chen |
| collection | DOAJ |
| description | Brain science, an emerging, dynamic, multidisciplinary basic research field, is generating numerous valuable data. However, there are still several obstacles for the utilization of these data, such as data fragmentation, heterogeneity, availability, and annotation divergence. Thus, to overcome these obstacles and construct an online community, we developed a panoramic database named Brain Research Hotspot Database (BRHD). As of 30 January 2022, the database had been integrated with standardized vocabularies from various resources, including 423,681 papers, 46,344 patents, 9585 transcriptomic datasets, 261 cell markers, as well as with information regarding brain initiatives that were officially launched and well-known scholars in brain research. Based on the keywords entered by users and the search options they set, data can be accessed and retrieved through exact and fuzzy search scenarios. In addition, for brain diseases, we developed three featured functions based on deep data mining: (1) a brain disease–genome network, which collects the associations between common brain diseases, genes, and mutations reported in the literature; (2) brain and gut microbiome associations, based on the literature related to this topic, with added annotations for reference; (3) 3D brain structure, containing a high-precision brain anatomy model with visual links to quickly connect to an organ-on-a-chip database. In short, the BRHD integrates data from a variety of brain science resources to provide a friendly user interface and freely accessible viewing and downloading environment. Furthermore, the original functions developed based on these data provide references and insights for brain research. |
| first_indexed | 2024-03-10T03:14:34Z |
| format | Article |
| id | doaj.art-72cf2b14c9a54ce1940f56a2d0bfb72b |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T03:14:34Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-72cf2b14c9a54ce1940f56a2d0bfb72b2023-11-23T10:18:17ZengMDPI AGBrain Sciences2076-34252022-05-0112563810.3390/brainsci12050638The Brain Research Hotspot Database (BRHD): A Panoramic Database of the Latest Hotspots in Brain ResearchPin Chen0Xue Lin1Anna Liu2Jian Li3The Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, School of Life Sciences and Technology, Southeast University, Nanjing 210018, ChinaDepartment of Bioinformatics, School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing 211166, ChinaThe Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, School of Life Sciences and Technology, Southeast University, Nanjing 210018, ChinaThe Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, School of Life Sciences and Technology, Southeast University, Nanjing 210018, ChinaBrain science, an emerging, dynamic, multidisciplinary basic research field, is generating numerous valuable data. However, there are still several obstacles for the utilization of these data, such as data fragmentation, heterogeneity, availability, and annotation divergence. Thus, to overcome these obstacles and construct an online community, we developed a panoramic database named Brain Research Hotspot Database (BRHD). As of 30 January 2022, the database had been integrated with standardized vocabularies from various resources, including 423,681 papers, 46,344 patents, 9585 transcriptomic datasets, 261 cell markers, as well as with information regarding brain initiatives that were officially launched and well-known scholars in brain research. Based on the keywords entered by users and the search options they set, data can be accessed and retrieved through exact and fuzzy search scenarios. In addition, for brain diseases, we developed three featured functions based on deep data mining: (1) a brain disease–genome network, which collects the associations between common brain diseases, genes, and mutations reported in the literature; (2) brain and gut microbiome associations, based on the literature related to this topic, with added annotations for reference; (3) 3D brain structure, containing a high-precision brain anatomy model with visual links to quickly connect to an organ-on-a-chip database. In short, the BRHD integrates data from a variety of brain science resources to provide a friendly user interface and freely accessible viewing and downloading environment. Furthermore, the original functions developed based on these data provide references and insights for brain research.https://www.mdpi.com/2076-3425/12/5/638brain sciencedatabasedisease-gene networkbrain and gut microbiome3D brain structure study |
| spellingShingle | Pin Chen Xue Lin Anna Liu Jian Li The Brain Research Hotspot Database (BRHD): A Panoramic Database of the Latest Hotspots in Brain Research Brain Sciences brain science database disease-gene network brain and gut microbiome 3D brain structure study |
| title | The Brain Research Hotspot Database (BRHD): A Panoramic Database of the Latest Hotspots in Brain Research |
| title_full | The Brain Research Hotspot Database (BRHD): A Panoramic Database of the Latest Hotspots in Brain Research |
| title_fullStr | The Brain Research Hotspot Database (BRHD): A Panoramic Database of the Latest Hotspots in Brain Research |
| title_full_unstemmed | The Brain Research Hotspot Database (BRHD): A Panoramic Database of the Latest Hotspots in Brain Research |
| title_short | The Brain Research Hotspot Database (BRHD): A Panoramic Database of the Latest Hotspots in Brain Research |
| title_sort | brain research hotspot database brhd a panoramic database of the latest hotspots in brain research |
| topic | brain science database disease-gene network brain and gut microbiome 3D brain structure study |
| url | https://www.mdpi.com/2076-3425/12/5/638 |
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