A DOSIMETRIC EVALUATION OBSERVATIONAL STUDY OF ADAPTIVE RADIATION THERAPY IN LIMITED-STAGE SMALL CELL LUNG CANCER.
Background Radiation therapy along with chemotherapy is proven to be effective in treating limited-stage small-cell lung cancer. However, the irradiation has deleterious effects on the other normal vital organs. Aim This study aimed to evaluate the efficacy and tolerability of adaptive radia...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Student's Journal of Health Research
2023-12-01
|
| Series: | Student's Journal of Health Research Africa |
| Subjects: | |
| Online Access: | https://sjhresearchafrica.org/index.php/public-html/article/view/824 |
| _version_ | 1797398905999065088 |
|---|---|
| author | Prince Kumar Kumar Prabhat |
| author_facet | Prince Kumar Kumar Prabhat |
| author_sort | Prince Kumar |
| collection | DOAJ |
| description |
Background
Radiation therapy along with chemotherapy is proven to be effective in treating limited-stage small-cell lung cancer. However, the irradiation has deleterious effects on the other normal vital organs.
Aim
This study aimed to evaluate the efficacy and tolerability of adaptive radiation therapy in treating LS-SCLC.
Methodology
30 patients participated in this observational study. Radiation therapy was given in 30 fractions, each with 60 units. The first CT was used to determine the dose and the progress of the disease after which 15 sessions of radiation out of 30 were conducted. 20-25 days after the first CT and the 15 fractions, a mid-treatment CT was conducted to evaluate the dose of radiation received by the target organs and the other vital organs. A dosimetry evaluation was conducted, and statistical analysis was done.
Results
The decrease in the tumour volume was significant from 185 cubic centimeters it reduced to 53 cubic centimeters. The difference in the values from the first CT and the mid-treatment CT was found to be statistically significant. The effect on the vital organs was comparatively lesser than the conventional radiotherapy.
Conclusion
Adaptive radiation therapy is found to be effective in treating limited-stage small cell cancer as indicated by the tumor size volume in the initial and during the treatment CT scan
Recommendation
Dosimetry evaluation can serve as an effective tool in determining the effect of irradiation on the vital organs and developing a further treatment plan.
|
| first_indexed | 2024-03-09T01:32:17Z |
| format | Article |
| id | doaj.art-72d01801b6eb4756b86be1010749a0d5 |
| institution | Directory Open Access Journal |
| issn | 2709-9997 |
| language | English |
| last_indexed | 2024-03-09T01:32:17Z |
| publishDate | 2023-12-01 |
| publisher | Student's Journal of Health Research |
| record_format | Article |
| series | Student's Journal of Health Research Africa |
| spelling | doaj.art-72d01801b6eb4756b86be1010749a0d52023-12-09T08:28:39ZengStudent's Journal of Health ResearchStudent's Journal of Health Research Africa2709-99972023-12-0141210.51168/sjhrafrica.v4i12.824A DOSIMETRIC EVALUATION OBSERVATIONAL STUDY OF ADAPTIVE RADIATION THERAPY IN LIMITED-STAGE SMALL CELL LUNG CANCER.Prince Kumar0Kumar Prabhat1Senior Resident, Department of Radiation Oncology, IGIMS Patna, Bihar, India.Kumar Prabhat, Senior Resident, DMCH Darbhanga, Bihar, India. Background Radiation therapy along with chemotherapy is proven to be effective in treating limited-stage small-cell lung cancer. However, the irradiation has deleterious effects on the other normal vital organs. Aim This study aimed to evaluate the efficacy and tolerability of adaptive radiation therapy in treating LS-SCLC. Methodology 30 patients participated in this observational study. Radiation therapy was given in 30 fractions, each with 60 units. The first CT was used to determine the dose and the progress of the disease after which 15 sessions of radiation out of 30 were conducted. 20-25 days after the first CT and the 15 fractions, a mid-treatment CT was conducted to evaluate the dose of radiation received by the target organs and the other vital organs. A dosimetry evaluation was conducted, and statistical analysis was done. Results The decrease in the tumour volume was significant from 185 cubic centimeters it reduced to 53 cubic centimeters. The difference in the values from the first CT and the mid-treatment CT was found to be statistically significant. The effect on the vital organs was comparatively lesser than the conventional radiotherapy. Conclusion Adaptive radiation therapy is found to be effective in treating limited-stage small cell cancer as indicated by the tumor size volume in the initial and during the treatment CT scan Recommendation Dosimetry evaluation can serve as an effective tool in determining the effect of irradiation on the vital organs and developing a further treatment plan. https://sjhresearchafrica.org/index.php/public-html/article/view/824adaptive radiation therapysmall cell lung cancerchemotherapy |
| spellingShingle | Prince Kumar Kumar Prabhat A DOSIMETRIC EVALUATION OBSERVATIONAL STUDY OF ADAPTIVE RADIATION THERAPY IN LIMITED-STAGE SMALL CELL LUNG CANCER. Student's Journal of Health Research Africa adaptive radiation therapy small cell lung cancer chemotherapy |
| title | A DOSIMETRIC EVALUATION OBSERVATIONAL STUDY OF ADAPTIVE RADIATION THERAPY IN LIMITED-STAGE SMALL CELL LUNG CANCER. |
| title_full | A DOSIMETRIC EVALUATION OBSERVATIONAL STUDY OF ADAPTIVE RADIATION THERAPY IN LIMITED-STAGE SMALL CELL LUNG CANCER. |
| title_fullStr | A DOSIMETRIC EVALUATION OBSERVATIONAL STUDY OF ADAPTIVE RADIATION THERAPY IN LIMITED-STAGE SMALL CELL LUNG CANCER. |
| title_full_unstemmed | A DOSIMETRIC EVALUATION OBSERVATIONAL STUDY OF ADAPTIVE RADIATION THERAPY IN LIMITED-STAGE SMALL CELL LUNG CANCER. |
| title_short | A DOSIMETRIC EVALUATION OBSERVATIONAL STUDY OF ADAPTIVE RADIATION THERAPY IN LIMITED-STAGE SMALL CELL LUNG CANCER. |
| title_sort | dosimetric evaluation observational study of adaptive radiation therapy in limited stage small cell lung cancer |
| topic | adaptive radiation therapy small cell lung cancer chemotherapy |
| url | https://sjhresearchafrica.org/index.php/public-html/article/view/824 |
| work_keys_str_mv | AT princekumar adosimetricevaluationobservationalstudyofadaptiveradiationtherapyinlimitedstagesmallcelllungcancer AT kumarprabhat adosimetricevaluationobservationalstudyofadaptiveradiationtherapyinlimitedstagesmallcelllungcancer AT princekumar dosimetricevaluationobservationalstudyofadaptiveradiationtherapyinlimitedstagesmallcelllungcancer AT kumarprabhat dosimetricevaluationobservationalstudyofadaptiveradiationtherapyinlimitedstagesmallcelllungcancer |