Antidiabetic potential of Conocarpus lancifolius
The antidiabetic activity of Conocarpus lancifolius extract was investigated in vitro, as alpha glucosidase inhibition and in vivo as alloxan induced diabetic rabbits with other biochemical parameters (LDL, HDL, SGPT, SGOT, cretinine, urea and triglyceride). Alpha-glucosidase inhibition activity was...
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| Format: | Article |
| Language: | English |
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Bangladesh Pharmacological Society
2014-06-01
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| Series: | Bangladesh Journal of Pharmacology |
| Subjects: | |
| Online Access: | https://www.banglajol.info/index.php/BJP/article/view/18556 |
| _version_ | 1818915978330767360 |
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| author | Malik Saadullah Bashir Ahmad Chaudary Muhammad Uzair Khurram Afzal |
| author_facet | Malik Saadullah Bashir Ahmad Chaudary Muhammad Uzair Khurram Afzal |
| author_sort | Malik Saadullah |
| collection | DOAJ |
| description | The antidiabetic activity of Conocarpus lancifolius extract was investigated in vitro, as alpha glucosidase inhibition and in vivo as alloxan induced diabetic rabbits with other biochemical parameters (LDL, HDL, SGPT, SGOT, cretinine, urea and triglyceride). Alpha-glucosidase inhibition activity was performed by using acorbose as standred. Methanolic extract show alpha-glucosidase inhibition activity. The dose of 200 mg/kg body weight significantly (p<0.05) decreases the blood glucose level, plasma total cholesterol, triglycerides and LDL in treated rabbits as compared to diabetic rabbits. This dose significantly increased the level of HDL in treated group. The activity of SGOT and SGPT also significantly (p<0.05) decreased in treated diabetic rabbits. Phytochemical studies show the presence of glycosides, tannins, saponins and terpenoids. The antidiabetic potential is may be due to its saponin contents. |
| first_indexed | 2024-12-20T00:10:52Z |
| format | Article |
| id | doaj.art-72d092e34497448f9c07c2178023a7f4 |
| institution | Directory Open Access Journal |
| issn | 1991-0088 |
| language | English |
| last_indexed | 2024-12-20T00:10:52Z |
| publishDate | 2014-06-01 |
| publisher | Bangladesh Pharmacological Society |
| record_format | Article |
| series | Bangladesh Journal of Pharmacology |
| spelling | doaj.art-72d092e34497448f9c07c2178023a7f42022-12-21T20:00:31ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-00882014-06-019210.3329/bjp.v9i2.18556Antidiabetic potential of Conocarpus lancifoliusMalik Saadullah0Bashir Ahmad Chaudary1Muhammad Uzair2Khurram Afzal3Faculty of Pharmacy, Bahauddin Zakariya University, MultanFaculty of Pharmacy, Bahauddin Zakariya University, MultanFaculty of Pharmacy, Bahauddin Zakariya University, MultanFaculty of Pharmacy, Bahauddin Zakariya University, MultanThe antidiabetic activity of Conocarpus lancifolius extract was investigated in vitro, as alpha glucosidase inhibition and in vivo as alloxan induced diabetic rabbits with other biochemical parameters (LDL, HDL, SGPT, SGOT, cretinine, urea and triglyceride). Alpha-glucosidase inhibition activity was performed by using acorbose as standred. Methanolic extract show alpha-glucosidase inhibition activity. The dose of 200 mg/kg body weight significantly (p<0.05) decreases the blood glucose level, plasma total cholesterol, triglycerides and LDL in treated rabbits as compared to diabetic rabbits. This dose significantly increased the level of HDL in treated group. The activity of SGOT and SGPT also significantly (p<0.05) decreased in treated diabetic rabbits. Phytochemical studies show the presence of glycosides, tannins, saponins and terpenoids. The antidiabetic potential is may be due to its saponin contents.https://www.banglajol.info/index.php/BJP/article/view/18556AntidiabeticAlloxanAlpha glycosidaseConocarpus lancifolius |
| spellingShingle | Malik Saadullah Bashir Ahmad Chaudary Muhammad Uzair Khurram Afzal Antidiabetic potential of Conocarpus lancifolius Bangladesh Journal of Pharmacology Antidiabetic Alloxan Alpha glycosidase Conocarpus lancifolius |
| title | Antidiabetic potential of Conocarpus lancifolius |
| title_full | Antidiabetic potential of Conocarpus lancifolius |
| title_fullStr | Antidiabetic potential of Conocarpus lancifolius |
| title_full_unstemmed | Antidiabetic potential of Conocarpus lancifolius |
| title_short | Antidiabetic potential of Conocarpus lancifolius |
| title_sort | antidiabetic potential of conocarpus lancifolius |
| topic | Antidiabetic Alloxan Alpha glycosidase Conocarpus lancifolius |
| url | https://www.banglajol.info/index.php/BJP/article/view/18556 |
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