The intracellular region of Notch ligands: does the tail make the difference?
<p>Abstract</p> <p/> <p>The cytoplasmic tail of Notch ligands drives endocytosis, mediates association with proteins implicated in the organization of cell-cell junctions and, through regulated intra-membrane proteolysis, is released from the membrane as a signaling fragment....
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2007-07-01
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| Series: | Biology Direct |
| Online Access: | http://www.biology-direct.com/content/2/1/19 |
| _version_ | 1831519175032438784 |
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| author | Pongor Sándor Ivanova Neli Popovic Matija De Biasio Alfredo Pintar Alessandro |
| author_facet | Pongor Sándor Ivanova Neli Popovic Matija De Biasio Alfredo Pintar Alessandro |
| author_sort | Pongor Sándor |
| collection | DOAJ |
| description | <p>Abstract</p> <p/> <p>The cytoplasmic tail of Notch ligands drives endocytosis, mediates association with proteins implicated in the organization of cell-cell junctions and, through regulated intra-membrane proteolysis, is released from the membrane as a signaling fragment. We survey these findings and discuss the role of Notch ligands intracellular region in bidirectional signaling and possibly in signal modulation in mammals.</p> <p>Reviewers</p> <p>This article was reviewed by Frank Eisenhaber, L Aravind, and Eugene V. Koonin.</p> |
| first_indexed | 2024-12-13T17:10:02Z |
| format | Article |
| id | doaj.art-72d38d83f59e4e64a98ecbb5f20b80fe |
| institution | Directory Open Access Journal |
| issn | 1745-6150 |
| language | English |
| last_indexed | 2024-12-13T17:10:02Z |
| publishDate | 2007-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Biology Direct |
| spelling | doaj.art-72d38d83f59e4e64a98ecbb5f20b80fe2022-12-21T23:37:35ZengBMCBiology Direct1745-61502007-07-01211910.1186/1745-6150-2-19The intracellular region of Notch ligands: does the tail make the difference?Pongor SándorIvanova NeliPopovic MatijaDe Biasio AlfredoPintar Alessandro<p>Abstract</p> <p/> <p>The cytoplasmic tail of Notch ligands drives endocytosis, mediates association with proteins implicated in the organization of cell-cell junctions and, through regulated intra-membrane proteolysis, is released from the membrane as a signaling fragment. We survey these findings and discuss the role of Notch ligands intracellular region in bidirectional signaling and possibly in signal modulation in mammals.</p> <p>Reviewers</p> <p>This article was reviewed by Frank Eisenhaber, L Aravind, and Eugene V. Koonin.</p>http://www.biology-direct.com/content/2/1/19 |
| spellingShingle | Pongor Sándor Ivanova Neli Popovic Matija De Biasio Alfredo Pintar Alessandro The intracellular region of Notch ligands: does the tail make the difference? Biology Direct |
| title | The intracellular region of Notch ligands: does the tail make the difference? |
| title_full | The intracellular region of Notch ligands: does the tail make the difference? |
| title_fullStr | The intracellular region of Notch ligands: does the tail make the difference? |
| title_full_unstemmed | The intracellular region of Notch ligands: does the tail make the difference? |
| title_short | The intracellular region of Notch ligands: does the tail make the difference? |
| title_sort | intracellular region of notch ligands does the tail make the difference |
| url | http://www.biology-direct.com/content/2/1/19 |
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