The correlation between insulin-like growth factor 1 (IGF-1) and high sensitivity C-reactive protein (hs-CRP) in postmenopausal women
Background: Low circulating IGF-1 and high hs-CRP may be associated with cardiovascular diseases. Hence, it is an important question that is there any correlation between these important biomarkers? Since the correlation between IGF-1 and hs-CRP has not been adequately investigated, the main aim of...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Bushehr University of Medical Sciences
2015-05-01
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| Series: | Iranian South Medical Journal |
| Subjects: | |
| Online Access: | http://ismj.bpums.ac.ir/browse.php?a_code=A-10-3-598&slc_lang=en&sid=1 |
| _version_ | 1818788557113786368 |
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| author | Gholamreza Pourbehi Mohammadreza Kalantarhormozi Afshin Ostovar Samad Akbarzadeh Majid Assadi Sina Dobaradaran Iraj Nabipour Hossean Darabi |
| author_facet | Gholamreza Pourbehi Mohammadreza Kalantarhormozi Afshin Ostovar Samad Akbarzadeh Majid Assadi Sina Dobaradaran Iraj Nabipour Hossean Darabi |
| author_sort | Gholamreza Pourbehi |
| collection | DOAJ |
| description | Background: Low circulating IGF-1 and high hs-CRP may be associated with cardiovascular diseases. Hence, it is an important question that is there any correlation between these important biomarkers? Since the correlation between IGF-1 and hs-CRP has not been adequately investigated, the main aim of this study was to evaluate the association between these biomarkers among postmenopausal women. Materials and Methods: A total of 361 healthy Iranian postmenopausal women were randomly selected in a population-based study. The metabolic syndrome was defined according to NCEP, ATPIII criteria. Circulating hs-CRP and IGF-1 levels were measured by highly specific enzyme-linked immunosorbent assay method. Results: Women with higher than median hs-CRP levels had lower IGF-1 levels, in comparison to women with lower than median hs-CRP levels (p<0.0001). In multiple regression analysis, after adjustment for age and the metabolic syndrome, IGF-1 levels had a significant inverse correlation with circulating hs-CRP levels (β=-0.139, p<0.007). After adjustment for age, body mass index and type 2 diabetes mellitus, IGF-1 levels also showed an inverse correlation with hs-CRP levels (β=-0.130, p<0.014). Conclusion: There is a significant inverse correlation between serum IGF-1 and hs-CRP levels in postmenopausal women. This finding provides evidence of the potential cardioprotective effect of IGF-1 via anti-inflammatory mechanisms. |
| first_indexed | 2024-12-18T14:25:33Z |
| format | Article |
| id | doaj.art-72d54f2290eb4b1d979678fa1791c6b0 |
| institution | Directory Open Access Journal |
| issn | 1735-4374 1735-6954 |
| language | English |
| last_indexed | 2024-12-18T14:25:33Z |
| publishDate | 2015-05-01 |
| publisher | Bushehr University of Medical Sciences |
| record_format | Article |
| series | Iranian South Medical Journal |
| spelling | doaj.art-72d54f2290eb4b1d979678fa1791c6b02022-12-21T21:04:44ZengBushehr University of Medical SciencesIranian South Medical Journal1735-43741735-69542015-05-01182421432The correlation between insulin-like growth factor 1 (IGF-1) and high sensitivity C-reactive protein (hs-CRP) in postmenopausal womenGholamreza Pourbehi0Mohammadreza Kalantarhormozi1Afshin Ostovar2Samad Akbarzadeh3Majid Assadi4Sina Dobaradaran5Iraj Nabipour6Hossean Darabi7 Background: Low circulating IGF-1 and high hs-CRP may be associated with cardiovascular diseases. Hence, it is an important question that is there any correlation between these important biomarkers? Since the correlation between IGF-1 and hs-CRP has not been adequately investigated, the main aim of this study was to evaluate the association between these biomarkers among postmenopausal women. Materials and Methods: A total of 361 healthy Iranian postmenopausal women were randomly selected in a population-based study. The metabolic syndrome was defined according to NCEP, ATPIII criteria. Circulating hs-CRP and IGF-1 levels were measured by highly specific enzyme-linked immunosorbent assay method. Results: Women with higher than median hs-CRP levels had lower IGF-1 levels, in comparison to women with lower than median hs-CRP levels (p<0.0001). In multiple regression analysis, after adjustment for age and the metabolic syndrome, IGF-1 levels had a significant inverse correlation with circulating hs-CRP levels (β=-0.139, p<0.007). After adjustment for age, body mass index and type 2 diabetes mellitus, IGF-1 levels also showed an inverse correlation with hs-CRP levels (β=-0.130, p<0.014). Conclusion: There is a significant inverse correlation between serum IGF-1 and hs-CRP levels in postmenopausal women. This finding provides evidence of the potential cardioprotective effect of IGF-1 via anti-inflammatory mechanisms.http://ismj.bpums.ac.ir/browse.php?a_code=A-10-3-598&slc_lang=en&sid=1IGF-1 chronic inflammation CRP cardiovascular diseases metabolic syndrome |
| spellingShingle | Gholamreza Pourbehi Mohammadreza Kalantarhormozi Afshin Ostovar Samad Akbarzadeh Majid Assadi Sina Dobaradaran Iraj Nabipour Hossean Darabi The correlation between insulin-like growth factor 1 (IGF-1) and high sensitivity C-reactive protein (hs-CRP) in postmenopausal women Iranian South Medical Journal IGF-1 chronic inflammation CRP cardiovascular diseases metabolic syndrome |
| title | The correlation between insulin-like growth factor 1 (IGF-1) and high sensitivity C-reactive protein (hs-CRP) in postmenopausal women |
| title_full | The correlation between insulin-like growth factor 1 (IGF-1) and high sensitivity C-reactive protein (hs-CRP) in postmenopausal women |
| title_fullStr | The correlation between insulin-like growth factor 1 (IGF-1) and high sensitivity C-reactive protein (hs-CRP) in postmenopausal women |
| title_full_unstemmed | The correlation between insulin-like growth factor 1 (IGF-1) and high sensitivity C-reactive protein (hs-CRP) in postmenopausal women |
| title_short | The correlation between insulin-like growth factor 1 (IGF-1) and high sensitivity C-reactive protein (hs-CRP) in postmenopausal women |
| title_sort | correlation between insulin like growth factor 1 igf 1 and high sensitivity c reactive protein hs crp in postmenopausal women |
| topic | IGF-1 chronic inflammation CRP cardiovascular diseases metabolic syndrome |
| url | http://ismj.bpums.ac.ir/browse.php?a_code=A-10-3-598&slc_lang=en&sid=1 |
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