A Case of Trauma-Induced <i>Falciformispora lignatilis</i> Eumycetoma in a Renal Transplant Recipient
Mycetoma is a chronic, granulomatous, subcutaneous infection caused by several species of fungi and soil-inhabiting bacteria, and is divided into eumycetoma and actinomycetoma, respectively. Endemicity is described with worldwide distribution within the “mycetoma belt”; however, the global burden is...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-08-01
|
| Series: | Tropical Medicine and Infectious Disease |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2414-6366/6/3/144 |
| _version_ | 1797517069924696064 |
|---|---|
| author | Maxwell Olenski Catriona Halliday James Gullifer Elena Martinez Amy Crowe Harsha Sheorey Jonathan Darby |
| author_facet | Maxwell Olenski Catriona Halliday James Gullifer Elena Martinez Amy Crowe Harsha Sheorey Jonathan Darby |
| author_sort | Maxwell Olenski |
| collection | DOAJ |
| description | Mycetoma is a chronic, granulomatous, subcutaneous infection caused by several species of fungi and soil-inhabiting bacteria, and is divided into eumycetoma and actinomycetoma, respectively. Endemicity is described with worldwide distribution within the “mycetoma belt”; however, the global burden is ill-defined. Mycetoma is rare in Australia, with only a few published case reports. Over time, the breadth of eumycetoma pathogens has expanded with local epidemiology accounting for variations in regional prevalence. Direct inoculation of pathogens typically heralds the triad of subcutaneous mass, sinus formation and discharging grains. We describe a case of eumycetoma in a 48-year-old male Filipino renal transplant recipient who presented with a painless slow-growing elbow lesion. Ultrasonography revealed two ovoid masses and surgical excision ensued. Histopathology revealed necrotising granulomata with numerous chestnut-brown thick-walled cells, septate hyphae, and occasional grains. On suspicion of localised chromoblastomycosis, the isolate was sent to a reference laboratory which identified the fungus as <i>Falciformispora lignatilis</i>, an organism not hitherto associated with human infection. Amongst the solid organ transplant cohort, similar atypical presentations have been described. Clinicians need to consider eumycetoma where an epidemiological link with the tropics exists, especially in atypical presentations in transplant recipients, including absent preceding trauma. |
| first_indexed | 2024-03-10T07:09:41Z |
| format | Article |
| id | doaj.art-72d5adddab624d879569a69933afe5e4 |
| institution | Directory Open Access Journal |
| issn | 2414-6366 |
| language | English |
| last_indexed | 2024-03-10T07:09:41Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Tropical Medicine and Infectious Disease |
| spelling | doaj.art-72d5adddab624d879569a69933afe5e42023-11-22T15:32:20ZengMDPI AGTropical Medicine and Infectious Disease2414-63662021-08-016314410.3390/tropicalmed6030144A Case of Trauma-Induced <i>Falciformispora lignatilis</i> Eumycetoma in a Renal Transplant RecipientMaxwell Olenski0Catriona Halliday1James Gullifer2Elena Martinez3Amy Crowe4Harsha Sheorey5Jonathan Darby6Infectious Diseases Department, St Vincent’s Hospital, Melbourne, VIC 3065, AustraliaInstitute of Clinical Pathology and Medical Research, NSW Health Pathology, Westmead, NSW 2145, AustraliaPathology Department, St Vincent’s Hospital, Melbourne, VIC 3065, AustraliaInstitute of Clinical Pathology and Medical Research, NSW Health Pathology, Westmead, NSW 2145, AustraliaInfectious Diseases Department, St Vincent’s Hospital, Melbourne, VIC 3065, AustraliaMicrobiology Department, St Vincent’s Hospital, Melbourne, VIC 3065, AustraliaInfectious Diseases Department, St Vincent’s Hospital, Melbourne, VIC 3065, AustraliaMycetoma is a chronic, granulomatous, subcutaneous infection caused by several species of fungi and soil-inhabiting bacteria, and is divided into eumycetoma and actinomycetoma, respectively. Endemicity is described with worldwide distribution within the “mycetoma belt”; however, the global burden is ill-defined. Mycetoma is rare in Australia, with only a few published case reports. Over time, the breadth of eumycetoma pathogens has expanded with local epidemiology accounting for variations in regional prevalence. Direct inoculation of pathogens typically heralds the triad of subcutaneous mass, sinus formation and discharging grains. We describe a case of eumycetoma in a 48-year-old male Filipino renal transplant recipient who presented with a painless slow-growing elbow lesion. Ultrasonography revealed two ovoid masses and surgical excision ensued. Histopathology revealed necrotising granulomata with numerous chestnut-brown thick-walled cells, septate hyphae, and occasional grains. On suspicion of localised chromoblastomycosis, the isolate was sent to a reference laboratory which identified the fungus as <i>Falciformispora lignatilis</i>, an organism not hitherto associated with human infection. Amongst the solid organ transplant cohort, similar atypical presentations have been described. Clinicians need to consider eumycetoma where an epidemiological link with the tropics exists, especially in atypical presentations in transplant recipients, including absent preceding trauma.https://www.mdpi.com/2414-6366/6/3/144mycologymycetomaeumycetomatransplantimmunity |
| spellingShingle | Maxwell Olenski Catriona Halliday James Gullifer Elena Martinez Amy Crowe Harsha Sheorey Jonathan Darby A Case of Trauma-Induced <i>Falciformispora lignatilis</i> Eumycetoma in a Renal Transplant Recipient Tropical Medicine and Infectious Disease mycology mycetoma eumycetoma transplant immunity |
| title | A Case of Trauma-Induced <i>Falciformispora lignatilis</i> Eumycetoma in a Renal Transplant Recipient |
| title_full | A Case of Trauma-Induced <i>Falciformispora lignatilis</i> Eumycetoma in a Renal Transplant Recipient |
| title_fullStr | A Case of Trauma-Induced <i>Falciformispora lignatilis</i> Eumycetoma in a Renal Transplant Recipient |
| title_full_unstemmed | A Case of Trauma-Induced <i>Falciformispora lignatilis</i> Eumycetoma in a Renal Transplant Recipient |
| title_short | A Case of Trauma-Induced <i>Falciformispora lignatilis</i> Eumycetoma in a Renal Transplant Recipient |
| title_sort | case of trauma induced i falciformispora lignatilis i eumycetoma in a renal transplant recipient |
| topic | mycology mycetoma eumycetoma transplant immunity |
| url | https://www.mdpi.com/2414-6366/6/3/144 |
| work_keys_str_mv | AT maxwellolenski acaseoftraumainducedifalciformisporalignatilisieumycetomainarenaltransplantrecipient AT catrionahalliday acaseoftraumainducedifalciformisporalignatilisieumycetomainarenaltransplantrecipient AT jamesgullifer acaseoftraumainducedifalciformisporalignatilisieumycetomainarenaltransplantrecipient AT elenamartinez acaseoftraumainducedifalciformisporalignatilisieumycetomainarenaltransplantrecipient AT amycrowe acaseoftraumainducedifalciformisporalignatilisieumycetomainarenaltransplantrecipient AT harshasheorey acaseoftraumainducedifalciformisporalignatilisieumycetomainarenaltransplantrecipient AT jonathandarby acaseoftraumainducedifalciformisporalignatilisieumycetomainarenaltransplantrecipient AT maxwellolenski caseoftraumainducedifalciformisporalignatilisieumycetomainarenaltransplantrecipient AT catrionahalliday caseoftraumainducedifalciformisporalignatilisieumycetomainarenaltransplantrecipient AT jamesgullifer caseoftraumainducedifalciformisporalignatilisieumycetomainarenaltransplantrecipient AT elenamartinez caseoftraumainducedifalciformisporalignatilisieumycetomainarenaltransplantrecipient AT amycrowe caseoftraumainducedifalciformisporalignatilisieumycetomainarenaltransplantrecipient AT harshasheorey caseoftraumainducedifalciformisporalignatilisieumycetomainarenaltransplantrecipient AT jonathandarby caseoftraumainducedifalciformisporalignatilisieumycetomainarenaltransplantrecipient |