Whole exome sequencing identifies MAP3K1, MSH2, and MLH1 as potential cancer‐predisposing genes in familial early‐onset colorectal cancer

Whole exome sequencing identifies MAP3K1, MSH2, and MLH1 as potential cancer‐predisposing genes in familial early‐onset colorectal cancer

Abstract The incidence of early‐onset colorectal cancer (CRC), which affects people under 50, is increasing for unknown reasons. Additionally, no underlying genetic cause is found in 20%–30% of patients suspected of having familial CRC syndrome. Whole exome sequencing (WES) has generated evidence fo...

Descrición completa

Detalles Bibliográficos
Main Authors: Nayeralsadat Fatemi, Siang‐Jyun Tu, Chin‐Chun Chung, Pardis Ketabi Moghadam, Ehsan Nazemalhosseini Mojarad, Amir Sadeghi, Mehdi Totonchi, Hamid Asadzadeh Aghdaei, Jan‐Gowth Chang
Formato: Artigo
Idioma:English
Publicado: Wiley 2023-09-01
Series:Kaohsiung Journal of Medical Sciences
Subjects:
colorectal cancer
early‐onset
likely pathogenic
whole exome sequencing
Acceso en liña:https://doi.org/10.1002/kjm2.12715

Internet

https://doi.org/10.1002/kjm2.12715

Títulos similares