The prion-like transmission of tau oligomers via exosomes
The conversion and transmission of misfolded proteins established the basis for the prion concept. Neurodegenerative diseases are considered “prion-like” disorders that lack infectivity. Among them, tauopathies are characterized by the conversion of native tau protein into an abnormally folded aggre...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.974414/full |
| _version_ | 1818068459830902784 |
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| author | Noel A. Jackson Marcos J. Guerrero-Muñoz Diana L. Castillo-Carranza |
| author_facet | Noel A. Jackson Marcos J. Guerrero-Muñoz Diana L. Castillo-Carranza |
| author_sort | Noel A. Jackson |
| collection | DOAJ |
| description | The conversion and transmission of misfolded proteins established the basis for the prion concept. Neurodegenerative diseases are considered “prion-like” disorders that lack infectivity. Among them, tauopathies are characterized by the conversion of native tau protein into an abnormally folded aggregate. During the progression of the disease, misfolded tau polymerizes into oligomers and intracellular neurofibrillary tangles (NFTs). While the toxicity of NFTs is an ongoing debate, the contribution of tau oligomers to early onset neurodegenerative pathogenesis is accepted. Tau oligomers are readily transferred from neuron to neuron propagating through the brain inducing neurodegeneration. Recently, transmission of tau oligomers via exosomes is now proposed. There is still too much to uncover about tau misfolding and propagation. Here we summarize novel findings of tau oligomers transmission and propagation via exosomes. |
| first_indexed | 2024-12-10T15:39:55Z |
| format | Article |
| id | doaj.art-72d7ffaa19c54038a2398e1c629fd6a4 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-10T15:39:55Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-72d7ffaa19c54038a2398e1c629fd6a42022-12-22T01:43:08ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-08-011410.3389/fnagi.2022.974414974414The prion-like transmission of tau oligomers via exosomesNoel A. Jackson0Marcos J. Guerrero-Muñoz1Diana L. Castillo-Carranza2School of Public Health, Harvard University, Boston, MA, United StatesSchool of Medicine, University of Monterrey, San Pedro Garza García, MexicoSchool of Medicine, University of Monterrey, San Pedro Garza García, MexicoThe conversion and transmission of misfolded proteins established the basis for the prion concept. Neurodegenerative diseases are considered “prion-like” disorders that lack infectivity. Among them, tauopathies are characterized by the conversion of native tau protein into an abnormally folded aggregate. During the progression of the disease, misfolded tau polymerizes into oligomers and intracellular neurofibrillary tangles (NFTs). While the toxicity of NFTs is an ongoing debate, the contribution of tau oligomers to early onset neurodegenerative pathogenesis is accepted. Tau oligomers are readily transferred from neuron to neuron propagating through the brain inducing neurodegeneration. Recently, transmission of tau oligomers via exosomes is now proposed. There is still too much to uncover about tau misfolding and propagation. Here we summarize novel findings of tau oligomers transmission and propagation via exosomes.https://www.frontiersin.org/articles/10.3389/fnagi.2022.974414/fulltau oligomersexosomesvesiclesmisfoldingspreadingprion |
| spellingShingle | Noel A. Jackson Marcos J. Guerrero-Muñoz Diana L. Castillo-Carranza The prion-like transmission of tau oligomers via exosomes Frontiers in Aging Neuroscience tau oligomers exosomes vesicles misfolding spreading prion |
| title | The prion-like transmission of tau oligomers via exosomes |
| title_full | The prion-like transmission of tau oligomers via exosomes |
| title_fullStr | The prion-like transmission of tau oligomers via exosomes |
| title_full_unstemmed | The prion-like transmission of tau oligomers via exosomes |
| title_short | The prion-like transmission of tau oligomers via exosomes |
| title_sort | prion like transmission of tau oligomers via exosomes |
| topic | tau oligomers exosomes vesicles misfolding spreading prion |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.974414/full |
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