Idiopathic hypogonadotropic hypogonadism caused by compound heterozygosity for two novel mutations in the GNRH1 gene: a case report

Idiopathic hypogonadotropic hypogonadism caused by compound heterozygosity for two novel mutations in the GNRH1 gene: a case report

Abstract Background Idiopathic hypogonadotropic hypogonadism (IHH) is a rare congenital or acquired genetic disorder caused by gonadotropin-releasing hormone (GnRH) deficiency. IHH patients are divided into two major groups, hyposmic or anosmic IHH (Kallmann syndrome) and normosmic IHH (nIHH), accor...

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Bibliographic Details
Main Authors: Qingqing Tian, Jingjing Tang, Lihong Wang, Jiaojiao Liu, Xiangshan Li, Zhuozhuo Cao, Zhufang Tian
Format: Article
Language:English
Published: BMC 2023-10-01
Series:BMC Endocrine Disorders
Subjects:
Idiopathic hypogonadotropic hypogonadism
Gonadotropin-releasing hormone 1
Delayed puberty
Online Access:https://doi.org/10.1186/s12902-023-01455-7

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