Msh2-Msh3 Interferes with Okazaki Fragment Processing to Promote Trinucleotide Repeat Expansions

Msh2-Msh3 Interferes with Okazaki Fragment Processing to Promote Trinucleotide Repeat Expansions

Trinucleotide repeat (TNR) expansions are the underlying cause of more than 40 neurodegenerative and neuromuscular diseases, including myotonic dystrophy and Huntington’s disease. Although genetic evidence points to errors in DNA replication and/or repair as the cause of these diseases, clear molecu...

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Bibliographic Details
Main Authors: Athena Kantartzis, Gregory M. Williams, Lata Balakrishnan, Rick L. Roberts, Jennifer A. Surtees, Robert A. Bambara
Format: Article
Language:English
Published: Elsevier 2012-08-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124712001945

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