Derivados citotóxicos de vitanolidos isolados das folhas de Acnistus arborescens
In view of anticancer activity of 7 β-acetoxywithanolide D (2) and 7β-16α-diacetoxywithonide D (3), isolated from the leaves of Acnistus arborescens (Solanaceae), five withanolide derivatives were obtained and their structures were determined by NMR, MS and IV data analysis. The in vitro anticancer...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Química
2011-01-01
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| Series: | Química Nova |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000200013&lng=en&tlng=en |
| _version_ | 1818321664549584896 |
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| author | Sandro Minguzzi Lauro E. S. Barata Geoffrey A. Cordell |
| author_facet | Sandro Minguzzi Lauro E. S. Barata Geoffrey A. Cordell |
| author_sort | Sandro Minguzzi |
| collection | DOAJ |
| description | In view of anticancer activity of 7 β-acetoxywithanolide D (2) and 7β-16α-diacetoxywithonide D (3), isolated from the leaves of Acnistus arborescens (Solanaceae), five withanolide derivatives were obtained and their structures were determined by NMR, MS and IV data analysis. The in vitro anticancer activity of these derivatives was evaluated in a panel of cancer cell lines: human breast (BC-1), human lung (Lu1), human colon (Col2) and human oral epidermoid carcinoma (KB). Compounds 2a (acetylation of 2), 3b (oxidation of 3) and 2c (hydrogenation of 2) exhibited the highest anticancer activity against human lung cancer cells, with ED50 values of 0.19, 0.25 and 0.63 μg/mL, respectively. |
| first_indexed | 2024-12-13T10:44:30Z |
| format | Article |
| id | doaj.art-72dd9a7afecc41608a5183685675c105 |
| institution | Directory Open Access Journal |
| issn | 1678-7064 |
| language | English |
| last_indexed | 2024-12-13T10:44:30Z |
| publishDate | 2011-01-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Química Nova |
| spelling | doaj.art-72dd9a7afecc41608a5183685675c1052022-12-21T23:50:18ZengSociedade Brasileira de QuímicaQuímica Nova1678-70642011-01-0134223724110.1590/S0100-40422011000200013S0100-40422011000200013Derivados citotóxicos de vitanolidos isolados das folhas de Acnistus arborescensSandro Minguzzi0Lauro E. S. Barata1Geoffrey A. Cordell2Universidade Estadual de Mato Grosso do SulUniversidade Estadual de CampinasNatural Products Inc.In view of anticancer activity of 7 β-acetoxywithanolide D (2) and 7β-16α-diacetoxywithonide D (3), isolated from the leaves of Acnistus arborescens (Solanaceae), five withanolide derivatives were obtained and their structures were determined by NMR, MS and IV data analysis. The in vitro anticancer activity of these derivatives was evaluated in a panel of cancer cell lines: human breast (BC-1), human lung (Lu1), human colon (Col2) and human oral epidermoid carcinoma (KB). Compounds 2a (acetylation of 2), 3b (oxidation of 3) and 2c (hydrogenation of 2) exhibited the highest anticancer activity against human lung cancer cells, with ED50 values of 0.19, 0.25 and 0.63 μg/mL, respectively.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000200013&lng=en&tlng=enAcnistus arborescenswithanolides derivativeshuman lung cancer |
| spellingShingle | Sandro Minguzzi Lauro E. S. Barata Geoffrey A. Cordell Derivados citotóxicos de vitanolidos isolados das folhas de Acnistus arborescens Química Nova Acnistus arborescens withanolides derivatives human lung cancer |
| title | Derivados citotóxicos de vitanolidos isolados das folhas de Acnistus arborescens |
| title_full | Derivados citotóxicos de vitanolidos isolados das folhas de Acnistus arborescens |
| title_fullStr | Derivados citotóxicos de vitanolidos isolados das folhas de Acnistus arborescens |
| title_full_unstemmed | Derivados citotóxicos de vitanolidos isolados das folhas de Acnistus arborescens |
| title_short | Derivados citotóxicos de vitanolidos isolados das folhas de Acnistus arborescens |
| title_sort | derivados citotoxicos de vitanolidos isolados das folhas de acnistus arborescens |
| topic | Acnistus arborescens withanolides derivatives human lung cancer |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000200013&lng=en&tlng=en |
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