Small Nucleolar (Sno)RNA: Therapy Lays in Translation
The ribosome is one of the largest complexes in the cell. Adding to its complexity are more than 200 RNA modification sites present on ribosomal RNAs (rRNAs) in a single human ribosome. These modifications occur in functionally important regions of the rRNA molecule, and they are vital for ribosome...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Non-Coding RNA |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2311-553X/9/3/35 |
| _version_ | 1797593248662814720 |
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| author | Ofri Rabany Daphna Nachmani |
| author_facet | Ofri Rabany Daphna Nachmani |
| author_sort | Ofri Rabany |
| collection | DOAJ |
| description | The ribosome is one of the largest complexes in the cell. Adding to its complexity are more than 200 RNA modification sites present on ribosomal RNAs (rRNAs) in a single human ribosome. These modifications occur in functionally important regions of the rRNA molecule, and they are vital for ribosome function and proper gene expression. Until recent technological advancements, the study of rRNA modifications and their profiles has been extremely laborious, leaving many questions unanswered. Small nucleolar RNAs (snoRNAs) are non-coding RNAs that facilitate and dictate the specificity of rRNA modification deposition, making them an attractive target for ribosome modulation. Here, we propose that through the mapping of rRNA modification profiles, we can identify cell-specific modifications with high therapeutic potential. We also describe the challenges of achieving the targeting specificity needed to implement snoRNAs as therapeutic targets in cancers. |
| first_indexed | 2024-03-11T02:05:20Z |
| format | Article |
| id | doaj.art-72de35e676634ef0ac96316011d203cc |
| institution | Directory Open Access Journal |
| issn | 2311-553X |
| language | English |
| last_indexed | 2024-03-11T02:05:20Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Non-Coding RNA |
| spelling | doaj.art-72de35e676634ef0ac96316011d203cc2023-11-18T11:54:27ZengMDPI AGNon-Coding RNA2311-553X2023-06-01933510.3390/ncrna9030035Small Nucleolar (Sno)RNA: Therapy Lays in TranslationOfri Rabany0Daphna Nachmani1Department of Genetics, The Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Jerusalem 9190401, IsraelDepartment of Genetics, The Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Jerusalem 9190401, IsraelThe ribosome is one of the largest complexes in the cell. Adding to its complexity are more than 200 RNA modification sites present on ribosomal RNAs (rRNAs) in a single human ribosome. These modifications occur in functionally important regions of the rRNA molecule, and they are vital for ribosome function and proper gene expression. Until recent technological advancements, the study of rRNA modifications and their profiles has been extremely laborious, leaving many questions unanswered. Small nucleolar RNAs (snoRNAs) are non-coding RNAs that facilitate and dictate the specificity of rRNA modification deposition, making them an attractive target for ribosome modulation. Here, we propose that through the mapping of rRNA modification profiles, we can identify cell-specific modifications with high therapeutic potential. We also describe the challenges of achieving the targeting specificity needed to implement snoRNAs as therapeutic targets in cancers.https://www.mdpi.com/2311-553X/9/3/35snoRNAs2′-O-methylationribosometherapy |
| spellingShingle | Ofri Rabany Daphna Nachmani Small Nucleolar (Sno)RNA: Therapy Lays in Translation Non-Coding RNA snoRNAs 2′-O-methylation ribosome therapy |
| title | Small Nucleolar (Sno)RNA: Therapy Lays in Translation |
| title_full | Small Nucleolar (Sno)RNA: Therapy Lays in Translation |
| title_fullStr | Small Nucleolar (Sno)RNA: Therapy Lays in Translation |
| title_full_unstemmed | Small Nucleolar (Sno)RNA: Therapy Lays in Translation |
| title_short | Small Nucleolar (Sno)RNA: Therapy Lays in Translation |
| title_sort | small nucleolar sno rna therapy lays in translation |
| topic | snoRNAs 2′-O-methylation ribosome therapy |
| url | https://www.mdpi.com/2311-553X/9/3/35 |
| work_keys_str_mv | AT ofrirabany smallnucleolarsnornatherapylaysintranslation AT daphnanachmani smallnucleolarsnornatherapylaysintranslation |