Extracellular Vesicles Carry HIV Env and Facilitate Hiv Infection of Human Lymphoid Tissue
Abstract Cells productively infected with HIV-1 release virions along with extracellular vesicles (EVs) whose biogenesis, size, and physical properties resemble those of retroviruses. Here, we found that a significant number of EVs (exosomes) released by HIV-1 infected cells carry gp120 (Env), a vir...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-017-01739-8 |
| _version_ | 1818844212980875264 |
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| author | Anush Arakelyan Wendy Fitzgerald Sonia Zicari Christophe Vanpouille Leonid Margolis |
| author_facet | Anush Arakelyan Wendy Fitzgerald Sonia Zicari Christophe Vanpouille Leonid Margolis |
| author_sort | Anush Arakelyan |
| collection | DOAJ |
| description | Abstract Cells productively infected with HIV-1 release virions along with extracellular vesicles (EVs) whose biogenesis, size, and physical properties resemble those of retroviruses. Here, we found that a significant number of EVs (exosomes) released by HIV-1 infected cells carry gp120 (Env), a viral protein that mediates virus attachment and fusion to target cells, and also facilitates HIV infection in various indirect ways. Depletion of viral preparations of EVs, in particular of those that carry gp120, decreases viral infection of human lymphoid tissue ex vivo. Thus, EVs that carry Env identified in our work seem to facilitate HIV infection and therefore may constitute a new therapeutic target for antiviral strategy. |
| first_indexed | 2024-12-19T05:10:11Z |
| format | Article |
| id | doaj.art-72de3d4f33a14ec5b85b36987459cf7a |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-19T05:10:11Z |
| publishDate | 2017-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-72de3d4f33a14ec5b85b36987459cf7a2022-12-21T20:34:48ZengNature PortfolioScientific Reports2045-23222017-05-01711910.1038/s41598-017-01739-8Extracellular Vesicles Carry HIV Env and Facilitate Hiv Infection of Human Lymphoid TissueAnush Arakelyan0Wendy Fitzgerald1Sonia Zicari2Christophe Vanpouille3Leonid Margolis4Section of Intercellular Interactions, Eunice-Kennedy National Institute of Child Health and Human Development, National Institutes of HealthSection of Intercellular Interactions, Eunice-Kennedy National Institute of Child Health and Human Development, National Institutes of HealthSection of Intercellular Interactions, Eunice-Kennedy National Institute of Child Health and Human Development, National Institutes of HealthSection of Intercellular Interactions, Eunice-Kennedy National Institute of Child Health and Human Development, National Institutes of HealthSection of Intercellular Interactions, Eunice-Kennedy National Institute of Child Health and Human Development, National Institutes of HealthAbstract Cells productively infected with HIV-1 release virions along with extracellular vesicles (EVs) whose biogenesis, size, and physical properties resemble those of retroviruses. Here, we found that a significant number of EVs (exosomes) released by HIV-1 infected cells carry gp120 (Env), a viral protein that mediates virus attachment and fusion to target cells, and also facilitates HIV infection in various indirect ways. Depletion of viral preparations of EVs, in particular of those that carry gp120, decreases viral infection of human lymphoid tissue ex vivo. Thus, EVs that carry Env identified in our work seem to facilitate HIV infection and therefore may constitute a new therapeutic target for antiviral strategy.https://doi.org/10.1038/s41598-017-01739-8 |
| spellingShingle | Anush Arakelyan Wendy Fitzgerald Sonia Zicari Christophe Vanpouille Leonid Margolis Extracellular Vesicles Carry HIV Env and Facilitate Hiv Infection of Human Lymphoid Tissue Scientific Reports |
| title | Extracellular Vesicles Carry HIV Env and Facilitate Hiv Infection of Human Lymphoid Tissue |
| title_full | Extracellular Vesicles Carry HIV Env and Facilitate Hiv Infection of Human Lymphoid Tissue |
| title_fullStr | Extracellular Vesicles Carry HIV Env and Facilitate Hiv Infection of Human Lymphoid Tissue |
| title_full_unstemmed | Extracellular Vesicles Carry HIV Env and Facilitate Hiv Infection of Human Lymphoid Tissue |
| title_short | Extracellular Vesicles Carry HIV Env and Facilitate Hiv Infection of Human Lymphoid Tissue |
| title_sort | extracellular vesicles carry hiv env and facilitate hiv infection of human lymphoid tissue |
| url | https://doi.org/10.1038/s41598-017-01739-8 |
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