Modelling aggressive prostate cancers of young men in immune-competent mice, driven by isogenic Trp53 alterations and Pten loss

Modelling aggressive prostate cancers of young men in immune-competent mice, driven by isogenic Trp53 alterations and Pten loss

Abstract Understanding prostate cancer onset and progression in order to rationally treat this disease has been critically limited by a dire lack of relevant pre-clinical animal models. We have generated a set of genetically engineered mice that mimic human prostate cancer, initiated from the gland...

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Bibliographic Details
Main Authors: Javier Octavio Mejía-Hernández, Simon P. Keam, Reem Saleh, Fenella Muntz, Stephen B. Fox, David Byrne, Arielle Kogan, Lokman Pang, Jennifer Huynh, Cassandra Litchfield, Franco Caramia, Guillermina Lozano, Hua He, James M. You, Shahneen Sandhu, Scott G. Williams, Ygal Haupt, Sue Haupt
Format: Article
Language:English
Published: Nature Publishing Group 2022-09-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05211-y

Internet

https://doi.org/10.1038/s41419-022-05211-y

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