Extracellular Vesicles in Hematological Malignancies: From Biomarkers to Therapeutic Tools

Small extracellular vesicles (EVs) are a heterogenous group of lipid particles released by all cell types in physiological and pathological states. In hematological malignancies, tumor-derived EVs are critical players in mediating intercellular communications through the transfer of genetic material...

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Main Authors: Jihane Khalife, James F. Sanchez, Flavia Pichiorri
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Diagnostics
Subjects:
Online Access:https://www.mdpi.com/2075-4418/10/12/1065
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author Jihane Khalife
James F. Sanchez
Flavia Pichiorri
author_facet Jihane Khalife
James F. Sanchez
Flavia Pichiorri
author_sort Jihane Khalife
collection DOAJ
description Small extracellular vesicles (EVs) are a heterogenous group of lipid particles released by all cell types in physiological and pathological states. In hematological malignancies, tumor-derived EVs are critical players in mediating intercellular communications through the transfer of genetic materials and proteins between neoplastic cells themselves and to several components of the bone marrow microenvironment, rendering the latter a “stronger” niche supporting cancer cell proliferation, drug resistance, and escape from immune surveillance. In this context, the molecular cargoes of tumor-derived EVs reflect the nature and status of the cells of origin, making them specific therapeutic targets. Another important characteristic of EVs in hematological malignancies is their use as a potential “liquid biopsy” because of their high abundance in biofluids and their ability to protect their molecular cargoes from nuclease and protease degradation. Liquid biopsies are non-invasive blood tests that provide a molecular profiling clinical tool as an alternative method of disease stratification, especially in cancer patients where solid biopsies have limited accessibility. They offer accurate diagnoses and identify specific biomarkers for monitoring of disease progression and response to treatment. In this review, we will focus on the role of EVs in the most prevalent hematological malignancies, particularly on their prospective use as biomarkers in the context of liquid biopsies, as well as their molecular signature that identifies them as specific therapeutic targets for inhibiting cancer progression. We will also highlight their roles in modulating the immune response by acting as both immunosuppressors and activators of anti-tumor immunity.
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spelling doaj.art-72dec24b5e4340ac8974bcfc94e865fe2023-11-20T23:57:28ZengMDPI AGDiagnostics2075-44182020-12-011012106510.3390/diagnostics10121065Extracellular Vesicles in Hematological Malignancies: From Biomarkers to Therapeutic ToolsJihane Khalife0James F. Sanchez1Flavia Pichiorri2Judy and Bernard Briskin Center for Multiple Myeloma Research, City of Hope, Duarte, CA 91010, USAJudy and Bernard Briskin Center for Multiple Myeloma Research, City of Hope, Duarte, CA 91010, USAJudy and Bernard Briskin Center for Multiple Myeloma Research, City of Hope, Duarte, CA 91010, USASmall extracellular vesicles (EVs) are a heterogenous group of lipid particles released by all cell types in physiological and pathological states. In hematological malignancies, tumor-derived EVs are critical players in mediating intercellular communications through the transfer of genetic materials and proteins between neoplastic cells themselves and to several components of the bone marrow microenvironment, rendering the latter a “stronger” niche supporting cancer cell proliferation, drug resistance, and escape from immune surveillance. In this context, the molecular cargoes of tumor-derived EVs reflect the nature and status of the cells of origin, making them specific therapeutic targets. Another important characteristic of EVs in hematological malignancies is their use as a potential “liquid biopsy” because of their high abundance in biofluids and their ability to protect their molecular cargoes from nuclease and protease degradation. Liquid biopsies are non-invasive blood tests that provide a molecular profiling clinical tool as an alternative method of disease stratification, especially in cancer patients where solid biopsies have limited accessibility. They offer accurate diagnoses and identify specific biomarkers for monitoring of disease progression and response to treatment. In this review, we will focus on the role of EVs in the most prevalent hematological malignancies, particularly on their prospective use as biomarkers in the context of liquid biopsies, as well as their molecular signature that identifies them as specific therapeutic targets for inhibiting cancer progression. We will also highlight their roles in modulating the immune response by acting as both immunosuppressors and activators of anti-tumor immunity.https://www.mdpi.com/2075-4418/10/12/1065exosomesbiomarkersleukemialymphomamultiple myeloma
spellingShingle Jihane Khalife
James F. Sanchez
Flavia Pichiorri
Extracellular Vesicles in Hematological Malignancies: From Biomarkers to Therapeutic Tools
Diagnostics
exosomes
biomarkers
leukemia
lymphoma
multiple myeloma
title Extracellular Vesicles in Hematological Malignancies: From Biomarkers to Therapeutic Tools
title_full Extracellular Vesicles in Hematological Malignancies: From Biomarkers to Therapeutic Tools
title_fullStr Extracellular Vesicles in Hematological Malignancies: From Biomarkers to Therapeutic Tools
title_full_unstemmed Extracellular Vesicles in Hematological Malignancies: From Biomarkers to Therapeutic Tools
title_short Extracellular Vesicles in Hematological Malignancies: From Biomarkers to Therapeutic Tools
title_sort extracellular vesicles in hematological malignancies from biomarkers to therapeutic tools
topic exosomes
biomarkers
leukemia
lymphoma
multiple myeloma
url https://www.mdpi.com/2075-4418/10/12/1065
work_keys_str_mv AT jihanekhalife extracellularvesiclesinhematologicalmalignanciesfrombiomarkerstotherapeutictools
AT jamesfsanchez extracellularvesiclesinhematologicalmalignanciesfrombiomarkerstotherapeutictools
AT flaviapichiorri extracellularvesiclesinhematologicalmalignanciesfrombiomarkerstotherapeutictools