Long Term Results of Single-Fraction Carbon-Ion Radiotherapy for Non-small Cell Lung Cancer
Background: The purpose of the present study was to evaluate the efficacy and safety of single-fraction carbon-ion radiotherapy (CIRT) in patients with non-small cell lung cancer. Methods: Patients with histologically confirmed non-small cell lung cancer, stage T1-2N0M0, and treated with single-frac...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/1/112 |
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| author | Takashi Ono Naoyoshi Yamamoto Akihiro Nomoto Mio Nakajima Yuka Isozaki Goro Kasuya Hitoshi Ishikawa Kenji Nemoto Hiroshi Tsuji |
| author_facet | Takashi Ono Naoyoshi Yamamoto Akihiro Nomoto Mio Nakajima Yuka Isozaki Goro Kasuya Hitoshi Ishikawa Kenji Nemoto Hiroshi Tsuji |
| author_sort | Takashi Ono |
| collection | DOAJ |
| description | Background: The purpose of the present study was to evaluate the efficacy and safety of single-fraction carbon-ion radiotherapy (CIRT) in patients with non-small cell lung cancer. Methods: Patients with histologically confirmed non-small cell lung cancer, stage T1-2N0M0, and treated with single-fraction CIRT (50Gy (relative biological effectiveness)) between June 2011 and April 2016 were identified in our database and retrospectively analyzed. Toxicity was evaluated using the Common Terminology Criteria for Adverse Events version 4.0. Results: The study included 57 patients, 22 (38.6%) of whom had inoperable cancer. The median age was 75 years (range: 42–94 years), and the median follow-up time was 61 months (range: 6–97 months). The 3- and 5-year overall survival rates were 91.2% and 81.7%, respectively. All survivors were followed up for more than three years. The 3- and 5-year local control rates were 96.4% and 91.8%, respectively. No case of ≥ grade 2 pneumonitis was recorded. Conclusions: This study suggests that single-fraction CIRT for T1-2N0M0 non-small cell lung cancer patients is feasible and can be considered as one of the treatment choices, especially in medically inoperable patients. |
| first_indexed | 2024-03-10T13:35:51Z |
| format | Article |
| id | doaj.art-72e199c1959a4772aa0d36d5b9be2f63 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T13:35:51Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-72e199c1959a4772aa0d36d5b9be2f632023-11-21T07:34:42ZengMDPI AGCancers2072-66942020-12-0113111210.3390/cancers13010112Long Term Results of Single-Fraction Carbon-Ion Radiotherapy for Non-small Cell Lung CancerTakashi Ono0Naoyoshi Yamamoto1Akihiro Nomoto2Mio Nakajima3Yuka Isozaki4Goro Kasuya5Hitoshi Ishikawa6Kenji Nemoto7Hiroshi Tsuji8Department of Radiation Oncology, QST Hospital, 4-9-1 Anagawa, Inage-ku, Chiba-shi, Chiba 263-8555, JapanDepartment of Radiation Oncology, QST Hospital, 4-9-1 Anagawa, Inage-ku, Chiba-shi, Chiba 263-8555, JapanDepartment of Radiation Oncology, QST Hospital, 4-9-1 Anagawa, Inage-ku, Chiba-shi, Chiba 263-8555, JapanDepartment of Radiation Oncology, QST Hospital, 4-9-1 Anagawa, Inage-ku, Chiba-shi, Chiba 263-8555, JapanDepartment of Radiation Oncology, QST Hospital, 4-9-1 Anagawa, Inage-ku, Chiba-shi, Chiba 263-8555, JapanDepartment of Radiation Oncology, QST Hospital, 4-9-1 Anagawa, Inage-ku, Chiba-shi, Chiba 263-8555, JapanDepartment of Radiation Oncology, QST Hospital, 4-9-1 Anagawa, Inage-ku, Chiba-shi, Chiba 263-8555, JapanDepartment of Radiation Oncology, Faculty of Medicine, Yamagata University, 2-2-2, Iida-Nishi, Yamagata 990-9585, JapanDepartment of Radiation Oncology, QST Hospital, 4-9-1 Anagawa, Inage-ku, Chiba-shi, Chiba 263-8555, JapanBackground: The purpose of the present study was to evaluate the efficacy and safety of single-fraction carbon-ion radiotherapy (CIRT) in patients with non-small cell lung cancer. Methods: Patients with histologically confirmed non-small cell lung cancer, stage T1-2N0M0, and treated with single-fraction CIRT (50Gy (relative biological effectiveness)) between June 2011 and April 2016 were identified in our database and retrospectively analyzed. Toxicity was evaluated using the Common Terminology Criteria for Adverse Events version 4.0. Results: The study included 57 patients, 22 (38.6%) of whom had inoperable cancer. The median age was 75 years (range: 42–94 years), and the median follow-up time was 61 months (range: 6–97 months). The 3- and 5-year overall survival rates were 91.2% and 81.7%, respectively. All survivors were followed up for more than three years. The 3- and 5-year local control rates were 96.4% and 91.8%, respectively. No case of ≥ grade 2 pneumonitis was recorded. Conclusions: This study suggests that single-fraction CIRT for T1-2N0M0 non-small cell lung cancer patients is feasible and can be considered as one of the treatment choices, especially in medically inoperable patients.https://www.mdpi.com/2072-6694/13/1/112heavy ion radiotherapydose fractionationradiationcarcinomanon-small cell lung |
| spellingShingle | Takashi Ono Naoyoshi Yamamoto Akihiro Nomoto Mio Nakajima Yuka Isozaki Goro Kasuya Hitoshi Ishikawa Kenji Nemoto Hiroshi Tsuji Long Term Results of Single-Fraction Carbon-Ion Radiotherapy for Non-small Cell Lung Cancer Cancers heavy ion radiotherapy dose fractionation radiation carcinoma non-small cell lung |
| title | Long Term Results of Single-Fraction Carbon-Ion Radiotherapy for Non-small Cell Lung Cancer |
| title_full | Long Term Results of Single-Fraction Carbon-Ion Radiotherapy for Non-small Cell Lung Cancer |
| title_fullStr | Long Term Results of Single-Fraction Carbon-Ion Radiotherapy for Non-small Cell Lung Cancer |
| title_full_unstemmed | Long Term Results of Single-Fraction Carbon-Ion Radiotherapy for Non-small Cell Lung Cancer |
| title_short | Long Term Results of Single-Fraction Carbon-Ion Radiotherapy for Non-small Cell Lung Cancer |
| title_sort | long term results of single fraction carbon ion radiotherapy for non small cell lung cancer |
| topic | heavy ion radiotherapy dose fractionation radiation carcinoma non-small cell lung |
| url | https://www.mdpi.com/2072-6694/13/1/112 |
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