Exhaustion of CAR T cells: potential causes and solutions

Exhaustion of CAR T cells: potential causes and solutions

Abstract Chimeric antigen receptor (CAR) T cell therapy has attracted attention for its promising therapeutic effects on hematological malignancies. However, there are problems such as relapse during long-term follow-up and limited effect on solid tumors with this therapy. Exhaustion, which impairs...

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Bibliographic Details
Main Authors: Taku Kouro, Hidetomo Himuro, Tetsuro Sasada
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Journal of Translational Medicine
Subjects:
Chimeric antigen receptor
Exhaustion
Tonic signal
Engineered cell
Epigenetics
Online Access:https://doi.org/10.1186/s12967-022-03442-3

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