Upper Urinary Tract Urothelial Carcinoma in Eastern Taiwan: High Proportion Among All Urothelial Carcinomas and Correlation with Chronic Kidney Disease
This study investigated the incidence of upper urinary tract urothelial carcinoma (UUT-UC) in eastern Taiwan and its association with chronic kidney disease (CKD). Methods: A total of 110 patients with histologically proven UUT-UC over a recent 20-year period were retrospectively analyzed to determi...
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| Format: | Article |
| Language: | English |
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Elsevier
2007-12-01
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| Series: | Journal of the Formosan Medical Association |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664608600741 |
| _version_ | 1818892750931623936 |
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| author | Chia-Yen Chen Yung-Ming Liao Wei-Ming Tsai Hann-Chorng Kuo |
| author_facet | Chia-Yen Chen Yung-Ming Liao Wei-Ming Tsai Hann-Chorng Kuo |
| author_sort | Chia-Yen Chen |
| collection | DOAJ |
| description | This study investigated the incidence of upper urinary tract urothelial carcinoma (UUT-UC) in eastern Taiwan and its association with chronic kidney disease (CKD).
Methods: A total of 110 patients with histologically proven UUT-UC over a recent 20-year period were retrospectively analyzed to determine the clinical profile, overall survival and correlation with CKD.
Results: The mean age at diagnosis was 68.7 ± 9.8 years (range, 43–93 years), and the male to female ratio was 1 to 1.16 (51:59). The ratio of urothelial carcinoma (UC) of the renal pelvis to UC of the ureter to UC of the bladder was 1.2:1:6.7. UC of the renal pelvis accounted for 10.8% of all urinary tract UC, and for 41% of all renal cancer detected during the study period. The 2-, 5- and 10-year cancer-specific survival rates of patients with UUT-UC were 75%, 53.0% and 29%, respectively. Patients with high grade and high stage UUT-UC had significantly worse prognosis than those with low grade (p = 0.0047) and low stage (p = 0.0021). Of the 110 patients, 64 (58%) had impaired renal function (glomerular filtration rate < 60 mL/ min/1.73 m2; defined as CKD), including 14 (13%) with end-stage renal disease (ESRD) before diagnosis. Patients with CKD or ESRD had significantly worse prognosis than those with normal renal function (p = 0.0399). High grade UC was found in 35 of 58 patients with CKD or ESRD (60%), which was significantly higher than in patients with normal renal function (12/26, 26%; p = 0.019).
Conclusion: A high proportion of UUT-UC was observed among all UCs and a significantly higher percentage of high grade UUT-UC (60%) were found in patients with CKD or ESRD in eastern Taiwan. These findings suggest that CKD and ESRD might play a role in the development of UC especially in the upper urinary tract. |
| first_indexed | 2024-12-19T18:01:40Z |
| format | Article |
| id | doaj.art-72e5cb93c0f34dd29dacf574cf2e855c |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-12-19T18:01:40Z |
| publishDate | 2007-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-72e5cb93c0f34dd29dacf574cf2e855c2022-12-21T20:11:36ZengElsevierJournal of the Formosan Medical Association0929-66462007-12-011061299299810.1016/S0929-6646(08)60074-1Upper Urinary Tract Urothelial Carcinoma in Eastern Taiwan: High Proportion Among All Urothelial Carcinomas and Correlation with Chronic Kidney DiseaseChia-Yen ChenYung-Ming LiaoWei-Ming TsaiHann-Chorng KuoThis study investigated the incidence of upper urinary tract urothelial carcinoma (UUT-UC) in eastern Taiwan and its association with chronic kidney disease (CKD). Methods: A total of 110 patients with histologically proven UUT-UC over a recent 20-year period were retrospectively analyzed to determine the clinical profile, overall survival and correlation with CKD. Results: The mean age at diagnosis was 68.7 ± 9.8 years (range, 43–93 years), and the male to female ratio was 1 to 1.16 (51:59). The ratio of urothelial carcinoma (UC) of the renal pelvis to UC of the ureter to UC of the bladder was 1.2:1:6.7. UC of the renal pelvis accounted for 10.8% of all urinary tract UC, and for 41% of all renal cancer detected during the study period. The 2-, 5- and 10-year cancer-specific survival rates of patients with UUT-UC were 75%, 53.0% and 29%, respectively. Patients with high grade and high stage UUT-UC had significantly worse prognosis than those with low grade (p = 0.0047) and low stage (p = 0.0021). Of the 110 patients, 64 (58%) had impaired renal function (glomerular filtration rate < 60 mL/ min/1.73 m2; defined as CKD), including 14 (13%) with end-stage renal disease (ESRD) before diagnosis. Patients with CKD or ESRD had significantly worse prognosis than those with normal renal function (p = 0.0399). High grade UC was found in 35 of 58 patients with CKD or ESRD (60%), which was significantly higher than in patients with normal renal function (12/26, 26%; p = 0.019). Conclusion: A high proportion of UUT-UC was observed among all UCs and a significantly higher percentage of high grade UUT-UC (60%) were found in patients with CKD or ESRD in eastern Taiwan. These findings suggest that CKD and ESRD might play a role in the development of UC especially in the upper urinary tract.http://www.sciencedirect.com/science/article/pii/S0929664608600741chronic kidney diseaseend-stage renal diseaseupper urinary tract urothelial carcinoma |
| spellingShingle | Chia-Yen Chen Yung-Ming Liao Wei-Ming Tsai Hann-Chorng Kuo Upper Urinary Tract Urothelial Carcinoma in Eastern Taiwan: High Proportion Among All Urothelial Carcinomas and Correlation with Chronic Kidney Disease Journal of the Formosan Medical Association chronic kidney disease end-stage renal disease upper urinary tract urothelial carcinoma |
| title | Upper Urinary Tract Urothelial Carcinoma in Eastern Taiwan: High Proportion Among All Urothelial Carcinomas and Correlation with Chronic Kidney Disease |
| title_full | Upper Urinary Tract Urothelial Carcinoma in Eastern Taiwan: High Proportion Among All Urothelial Carcinomas and Correlation with Chronic Kidney Disease |
| title_fullStr | Upper Urinary Tract Urothelial Carcinoma in Eastern Taiwan: High Proportion Among All Urothelial Carcinomas and Correlation with Chronic Kidney Disease |
| title_full_unstemmed | Upper Urinary Tract Urothelial Carcinoma in Eastern Taiwan: High Proportion Among All Urothelial Carcinomas and Correlation with Chronic Kidney Disease |
| title_short | Upper Urinary Tract Urothelial Carcinoma in Eastern Taiwan: High Proportion Among All Urothelial Carcinomas and Correlation with Chronic Kidney Disease |
| title_sort | upper urinary tract urothelial carcinoma in eastern taiwan high proportion among all urothelial carcinomas and correlation with chronic kidney disease |
| topic | chronic kidney disease end-stage renal disease upper urinary tract urothelial carcinoma |
| url | http://www.sciencedirect.com/science/article/pii/S0929664608600741 |
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