In vitro Effects of Methanol Extracts of Korean Medicinal Fruits (Persimmon, Raspberry, Tomato) on Chicken Lymphocytes, Macrophages, and Tumor Cells
A variety of fruits have traditionally been used in Asian cultures to enhance resistance to diseases and treat cancers. However, limited information exists on the underlying mechanisms responsible for these effects. The present investigation was conducted to examine the ability of three Korean ind...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Japan Poultry Science Association
2009-04-01
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| Series: | The Journal of Poultry Science |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/jpsa/46/2/46_2_149/_pdf/-char/en |
| _version_ | 1797816258018672640 |
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| author | Sung-Hyen Lee Hyun S. Lillehoj Hye-Kyung Chun Hong-Ju Park Soo-Muk Cho Erik P. Lillehoj |
| author_facet | Sung-Hyen Lee Hyun S. Lillehoj Hye-Kyung Chun Hong-Ju Park Soo-Muk Cho Erik P. Lillehoj |
| author_sort | Sung-Hyen Lee |
| collection | DOAJ |
| description | A variety of fruits have traditionally been used in Asian cultures to enhance resistance to diseases and treat cancers. However, limited information exists on the underlying mechanisms responsible for these effects. The present investigation was conducted to examine the ability of three Korean indigenous fruits (persimmon, raspberry and tomato) to stimulate lymphocyte proliferation and macrophage nitric oxide production as parameters of innate immunity, and to inhibit tumor cell growth. In vitro co-culture of chicken spleen lymphocytes with methanol extracts of persimmon (Diospyros kaki) or tomato (Lycopersicon esculentum) induced greater cell proliferation compared with cells treated with the vehicle control. Stimulation of chicken macrophages with extracts of persimmon or raspberry (Rubus crataegifolius), but not tomato, stimulated robust nitric oxide production to levels similar to that produced by interferon-γ. All fruit extracts uniformly inhibited the growth chicken tumor cells in vitro. These results provide a rational basis for future studies investigating the effects of medicinal fruits on innate immunity and carcinogenesis in humans and animals. |
| first_indexed | 2024-03-13T08:35:00Z |
| format | Article |
| id | doaj.art-72e76383249e4f3badcf09bf73427802 |
| institution | Directory Open Access Journal |
| issn | 1346-7395 1349-0486 |
| language | English |
| last_indexed | 2024-03-13T08:35:00Z |
| publishDate | 2009-04-01 |
| publisher | Japan Poultry Science Association |
| record_format | Article |
| series | The Journal of Poultry Science |
| spelling | doaj.art-72e76383249e4f3badcf09bf734278022023-05-31T00:45:14ZengJapan Poultry Science AssociationThe Journal of Poultry Science1346-73951349-04862009-04-0146214915410.2141/jpsa.46.149jpsaIn vitro Effects of Methanol Extracts of Korean Medicinal Fruits (Persimmon, Raspberry, Tomato) on Chicken Lymphocytes, Macrophages, and Tumor CellsSung-Hyen Lee0Hyun S. Lillehoj1Hye-Kyung Chun2Hong-Ju Park3Soo-Muk Cho4Erik P. Lillehoj5Animal and Natural Resources Institute, Beltsville Agricultural Research Center, Agricultural Research Service, United States Department of Agriculture, USAAnimal and Natural Resources Institute, Beltsville Agricultural Research Center, Agricultural Research Service, United States Department of Agriculture, USADepartment of Korean Food Research for Globalization, National Academy of Agricultural Science, Rural Development Administration, South KoreaDepartment of Korean Food Research for Globalization, National Academy of Agricultural Science, Rural Development Administration, South KoreaDepartment of Korean Food Research for Globalization, National Academy of Agricultural Science, Rural Development Administration, South KoreaDepartment of Pediatrics University of Maryland School of Medicine, USAA variety of fruits have traditionally been used in Asian cultures to enhance resistance to diseases and treat cancers. However, limited information exists on the underlying mechanisms responsible for these effects. The present investigation was conducted to examine the ability of three Korean indigenous fruits (persimmon, raspberry and tomato) to stimulate lymphocyte proliferation and macrophage nitric oxide production as parameters of innate immunity, and to inhibit tumor cell growth. In vitro co-culture of chicken spleen lymphocytes with methanol extracts of persimmon (Diospyros kaki) or tomato (Lycopersicon esculentum) induced greater cell proliferation compared with cells treated with the vehicle control. Stimulation of chicken macrophages with extracts of persimmon or raspberry (Rubus crataegifolius), but not tomato, stimulated robust nitric oxide production to levels similar to that produced by interferon-γ. All fruit extracts uniformly inhibited the growth chicken tumor cells in vitro. These results provide a rational basis for future studies investigating the effects of medicinal fruits on innate immunity and carcinogenesis in humans and animals.https://www.jstage.jst.go.jp/article/jpsa/46/2/46_2_149/_pdf/-char/enfruitimmunomodulationmacrophagesplenocytetumor |
| spellingShingle | Sung-Hyen Lee Hyun S. Lillehoj Hye-Kyung Chun Hong-Ju Park Soo-Muk Cho Erik P. Lillehoj In vitro Effects of Methanol Extracts of Korean Medicinal Fruits (Persimmon, Raspberry, Tomato) on Chicken Lymphocytes, Macrophages, and Tumor Cells The Journal of Poultry Science fruit immunomodulation macrophage splenocyte tumor |
| title | In vitro Effects of Methanol Extracts of Korean Medicinal Fruits (Persimmon, Raspberry, Tomato) on Chicken Lymphocytes, Macrophages, and Tumor Cells |
| title_full | In vitro Effects of Methanol Extracts of Korean Medicinal Fruits (Persimmon, Raspberry, Tomato) on Chicken Lymphocytes, Macrophages, and Tumor Cells |
| title_fullStr | In vitro Effects of Methanol Extracts of Korean Medicinal Fruits (Persimmon, Raspberry, Tomato) on Chicken Lymphocytes, Macrophages, and Tumor Cells |
| title_full_unstemmed | In vitro Effects of Methanol Extracts of Korean Medicinal Fruits (Persimmon, Raspberry, Tomato) on Chicken Lymphocytes, Macrophages, and Tumor Cells |
| title_short | In vitro Effects of Methanol Extracts of Korean Medicinal Fruits (Persimmon, Raspberry, Tomato) on Chicken Lymphocytes, Macrophages, and Tumor Cells |
| title_sort | in vitro effects of methanol extracts of korean medicinal fruits persimmon raspberry tomato on chicken lymphocytes macrophages and tumor cells |
| topic | fruit immunomodulation macrophage splenocyte tumor |
| url | https://www.jstage.jst.go.jp/article/jpsa/46/2/46_2_149/_pdf/-char/en |
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