Antibody–Drug Conjugates in Breast Cancer: Current Status and Future Directions
Antibody drug conjugates (ADCs) are novel medications that combine monoclonal antibodies with cytotoxic payloads, enabling the selective delivery of potent drugs to cancer cells expressing specific surface antigens. This targeted strategy seeks to optimize treatment effectiveness while reducing the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/18/13726 |
| _version_ | 1797579731130908672 |
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| author | Cynthia Mark Jin Sun Lee Xiaojiang Cui Yuan Yuan |
| author_facet | Cynthia Mark Jin Sun Lee Xiaojiang Cui Yuan Yuan |
| author_sort | Cynthia Mark |
| collection | DOAJ |
| description | Antibody drug conjugates (ADCs) are novel medications that combine monoclonal antibodies with cytotoxic payloads, enabling the selective delivery of potent drugs to cancer cells expressing specific surface antigens. This targeted strategy seeks to optimize treatment effectiveness while reducing the risk of systemic toxicity, distinguishing ADCs from conventional chemotherapy. The rapid growth in ADC research has led to numerous developments and approvals for cancer treatment, with significant impacts on the management of breast cancer. ADCs like T-DXd for HER2-low disease and sacituzumab govitecan for triple negative breast cancer (TNBC) have provided valuable options for challenging subtypes of breast cancer. However, essential questions still need to be addressed, including the optimal order of ADCs amidst the growing number of newly developed ones and strategies to overcome resistance mechanisms. Preclinical studies have shed light on potential resistance mechanisms, emphasizing the potential benefit of combinational approaches with other agents such as immune checkpoint inhibitors (ICIs) and targeted tyrosine kinase inhibitors (TKIs) to enhance treatment effectiveness. Additionally, personalized approaches based on molecular profiling hold promise in tailoring ADC treatments to individual tumors, identifying unique molecular markers for each patient to optimize treatment efficacy while minimizing side effects. |
| first_indexed | 2024-03-10T22:41:16Z |
| format | Article |
| id | doaj.art-72e8b02b83454c7c84e229b61b352aea |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T22:41:16Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-72e8b02b83454c7c84e229b61b352aea2023-11-19T11:02:11ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-09-0124181372610.3390/ijms241813726Antibody–Drug Conjugates in Breast Cancer: Current Status and Future DirectionsCynthia Mark0Jin Sun Lee1Xiaojiang Cui2Yuan Yuan3Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USADepartment of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USADepartment of Surgery, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USADepartment of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USAAntibody drug conjugates (ADCs) are novel medications that combine monoclonal antibodies with cytotoxic payloads, enabling the selective delivery of potent drugs to cancer cells expressing specific surface antigens. This targeted strategy seeks to optimize treatment effectiveness while reducing the risk of systemic toxicity, distinguishing ADCs from conventional chemotherapy. The rapid growth in ADC research has led to numerous developments and approvals for cancer treatment, with significant impacts on the management of breast cancer. ADCs like T-DXd for HER2-low disease and sacituzumab govitecan for triple negative breast cancer (TNBC) have provided valuable options for challenging subtypes of breast cancer. However, essential questions still need to be addressed, including the optimal order of ADCs amidst the growing number of newly developed ones and strategies to overcome resistance mechanisms. Preclinical studies have shed light on potential resistance mechanisms, emphasizing the potential benefit of combinational approaches with other agents such as immune checkpoint inhibitors (ICIs) and targeted tyrosine kinase inhibitors (TKIs) to enhance treatment effectiveness. Additionally, personalized approaches based on molecular profiling hold promise in tailoring ADC treatments to individual tumors, identifying unique molecular markers for each patient to optimize treatment efficacy while minimizing side effects.https://www.mdpi.com/1422-0067/24/18/13726antibody–drug conjugatesbreast cancerdrug resistance |
| spellingShingle | Cynthia Mark Jin Sun Lee Xiaojiang Cui Yuan Yuan Antibody–Drug Conjugates in Breast Cancer: Current Status and Future Directions International Journal of Molecular Sciences antibody–drug conjugates breast cancer drug resistance |
| title | Antibody–Drug Conjugates in Breast Cancer: Current Status and Future Directions |
| title_full | Antibody–Drug Conjugates in Breast Cancer: Current Status and Future Directions |
| title_fullStr | Antibody–Drug Conjugates in Breast Cancer: Current Status and Future Directions |
| title_full_unstemmed | Antibody–Drug Conjugates in Breast Cancer: Current Status and Future Directions |
| title_short | Antibody–Drug Conjugates in Breast Cancer: Current Status and Future Directions |
| title_sort | antibody drug conjugates in breast cancer current status and future directions |
| topic | antibody–drug conjugates breast cancer drug resistance |
| url | https://www.mdpi.com/1422-0067/24/18/13726 |
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