Screening Dys-Methylation Genes and Rules for Cancer Diagnosis by Using the Pan-Cancer Study
Although cancer has long been a major public health problem worldwide, conquering cancer still remains unachievable due to its complexity and diversity. With the development of high-throughput sequencing technologies, the combination of conventional clinical symptoms and new genetic events is becomi...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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IEEE
2020-01-01
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| Series: | IEEE Access |
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| Online Access: | https://ieeexplore.ieee.org/document/8938693/ |
| _version_ | 1818917796322476032 |
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| author | Yu-Hang Zhang Tao Zeng Xiaoyong Pan Wei Guo Zijun Gan Yunhua Zhang Tao Huang Yu-Dong Cai |
| author_facet | Yu-Hang Zhang Tao Zeng Xiaoyong Pan Wei Guo Zijun Gan Yunhua Zhang Tao Huang Yu-Dong Cai |
| author_sort | Yu-Hang Zhang |
| collection | DOAJ |
| description | Although cancer has long been a major public health problem worldwide, conquering cancer still remains unachievable due to its complexity and diversity. With the development of high-throughput sequencing technologies, the combination of conventional clinical symptoms and new genetic events is becoming effective and has been approved for precise prediction and innovative diagnostic strategies. Epigenetic modification (e.g., DNA methylation) is an important mechanism of transcriptional control in normal or disease functions. Depending on the unique methylation profiles, an important possibility raised is that the characteristic of dys-methylation could provide a new molecular marker system for the identification of the major forms of tumors. In this study, we attempted to distinguish different tumor types. On the basis of DNA methylation data from PanCanAtlas in The Cancer Genome Atlas, we applied mRMR and MCFS methods together to identify the decision rules for distinguishing 33 different tumor types and ranked the features that characterized methylation level. This study highlights the considerable application potential of methylation features in cancer diagnosis and provides insight into novel therapeutic targets. |
| first_indexed | 2024-12-20T00:39:45Z |
| format | Article |
| id | doaj.art-72ea7395cccd42c2ac963d4d48d46393 |
| institution | Directory Open Access Journal |
| issn | 2169-3536 |
| language | English |
| last_indexed | 2024-12-20T00:39:45Z |
| publishDate | 2020-01-01 |
| publisher | IEEE |
| record_format | Article |
| series | IEEE Access |
| spelling | doaj.art-72ea7395cccd42c2ac963d4d48d463932022-12-21T19:59:39ZengIEEEIEEE Access2169-35362020-01-01848950110.1109/ACCESS.2019.29614028938693Screening Dys-Methylation Genes and Rules for Cancer Diagnosis by Using the Pan-Cancer StudyYu-Hang Zhang0https://orcid.org/0000-0003-3825-0796Tao Zeng1https://orcid.org/0000-0002-0295-3994Xiaoyong Pan2https://orcid.org/0000-0001-5010-464XWei Guo3https://orcid.org/0000-0001-5294-5047Zijun Gan4https://orcid.org/0000-0002-4110-897XYunhua Zhang5Tao Huang6https://orcid.org/0000-0003-1975-9693Yu-Dong Cai7https://orcid.org/0000-0001-5664-7979School of Life Sciences, Shanghai University, Shanghai, ChinaKey Laboratory of Systems Biology, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, ChinaInstitute of Image Processing and Pattern Recognition, Shanghai Jiao Tong University, Shanghai, ChinaInstitute of Health Sciences, Shanghai Jiao Tong University School of Medicine and Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, ChinaShanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, ChinaAnhui Province Key Laboratory of Farmland Ecological Conservation and Pollution Prevention, School of Resources and Environment, Anhui Agricultural University, Hefei, ChinaShanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, ChinaSchool of Life Sciences, Shanghai University, Shanghai, ChinaAlthough cancer has long been a major public health problem worldwide, conquering cancer still remains unachievable due to its complexity and diversity. With the development of high-throughput sequencing technologies, the combination of conventional clinical symptoms and new genetic events is becoming effective and has been approved for precise prediction and innovative diagnostic strategies. Epigenetic modification (e.g., DNA methylation) is an important mechanism of transcriptional control in normal or disease functions. Depending on the unique methylation profiles, an important possibility raised is that the characteristic of dys-methylation could provide a new molecular marker system for the identification of the major forms of tumors. In this study, we attempted to distinguish different tumor types. On the basis of DNA methylation data from PanCanAtlas in The Cancer Genome Atlas, we applied mRMR and MCFS methods together to identify the decision rules for distinguishing 33 different tumor types and ranked the features that characterized methylation level. This study highlights the considerable application potential of methylation features in cancer diagnosis and provides insight into novel therapeutic targets.https://ieeexplore.ieee.org/document/8938693/Methylationrulecancer diagnosispan-cancer |
| spellingShingle | Yu-Hang Zhang Tao Zeng Xiaoyong Pan Wei Guo Zijun Gan Yunhua Zhang Tao Huang Yu-Dong Cai Screening Dys-Methylation Genes and Rules for Cancer Diagnosis by Using the Pan-Cancer Study IEEE Access Methylation rule cancer diagnosis pan-cancer |
| title | Screening Dys-Methylation Genes and Rules for Cancer Diagnosis by Using the Pan-Cancer Study |
| title_full | Screening Dys-Methylation Genes and Rules for Cancer Diagnosis by Using the Pan-Cancer Study |
| title_fullStr | Screening Dys-Methylation Genes and Rules for Cancer Diagnosis by Using the Pan-Cancer Study |
| title_full_unstemmed | Screening Dys-Methylation Genes and Rules for Cancer Diagnosis by Using the Pan-Cancer Study |
| title_short | Screening Dys-Methylation Genes and Rules for Cancer Diagnosis by Using the Pan-Cancer Study |
| title_sort | screening dys methylation genes and rules for cancer diagnosis by using the pan cancer study |
| topic | Methylation rule cancer diagnosis pan-cancer |
| url | https://ieeexplore.ieee.org/document/8938693/ |
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