A meta-analysis of the pooled impact of CYP7A1 single nucleotide polymorphisms on serum lipid responses to statins
Background and Aims: Various publications suggested that there is an association between CYP7A1 single nucleotide polymorphisms (SNP) and a reduced response to statin therapy, but the results were inconsistent. This study aimed to collectively review these publications to appraise the effect of stat...
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2023.1199549/full |
| _version_ | 1797806034575687680 |
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| author | Megan Yu Cai Lim Jia Rong Tee Wai-Ping Yau Han Kiat Ho |
| author_facet | Megan Yu Cai Lim Jia Rong Tee Wai-Ping Yau Han Kiat Ho |
| author_sort | Megan Yu Cai Lim |
| collection | DOAJ |
| description | Background and Aims: Various publications suggested that there is an association between CYP7A1 single nucleotide polymorphisms (SNP) and a reduced response to statin therapy, but the results were inconsistent. This study aimed to collectively review these publications to appraise the effect of statins on cholesterol control in carriers of CYP7A1 variant alleles.Methods: PUBMED, Cochrane and EMBASE were searched systematically to identify reported studies on the lipid responses to statin treatment between carriers of the variant allele versus the non-variant allele of CYP7A1 SNPs. The change from baseline in lipid responses for all included studies were calculated using weighted mean differences (WMD) (with 95% confidence interval (CI)). A meta-analysis was conducted to pool results using either the random-effects model or the fixed effects model.Results: A total of 6 publications comprising of 1,686 subjects for the assessment of total cholesterol, LDL-C and HDL-C and 1,156 subjects for the assessment of triglycerides were included in the meta-analyses. Subjects who were non-carriers of a CYP7A1 SNP (−204 A/C (rs3808607), −278 A/C (rs3808607) and rs8192875) had a greater reduction in total cholesterol (overall WMD -0.17, 95% CI -0.29, −0.06) and LDL-C levels (overall WMD -0.16, 95% CI -0.26, −0.05) as compared with subjects who borne the variant allele of CYP7A1 SNPs when administered a statin.Conclusion: The presence of variant allele of CYP7A1 SNPs may result in suboptimal control of total cholesterol and LDL-C levels as compared with individuals who do not carry the variant allele, when administered an equivalent dose of statin. |
| first_indexed | 2024-03-13T06:01:09Z |
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| language | English |
| last_indexed | 2024-03-13T06:01:09Z |
| publishDate | 2023-06-01 |
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| series | Frontiers in Genetics |
| spelling | doaj.art-72ea7b34c17247adbadefe8751c420c62023-06-12T15:46:22ZengFrontiers Media S.A.Frontiers in Genetics1664-80212023-06-011410.3389/fgene.2023.11995491199549A meta-analysis of the pooled impact of CYP7A1 single nucleotide polymorphisms on serum lipid responses to statinsMegan Yu Cai Lim0Jia Rong Tee1Wai-Ping Yau2Han Kiat Ho3Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore, SingaporeDepartment of Mathematics, Faculty of Science, National University of Singapore, Singapore, SingaporeDepartment of Pharmacy, Faculty of Science, National University of Singapore, Singapore, SingaporeDepartment of Pharmacy, Faculty of Science, National University of Singapore, Singapore, SingaporeBackground and Aims: Various publications suggested that there is an association between CYP7A1 single nucleotide polymorphisms (SNP) and a reduced response to statin therapy, but the results were inconsistent. This study aimed to collectively review these publications to appraise the effect of statins on cholesterol control in carriers of CYP7A1 variant alleles.Methods: PUBMED, Cochrane and EMBASE were searched systematically to identify reported studies on the lipid responses to statin treatment between carriers of the variant allele versus the non-variant allele of CYP7A1 SNPs. The change from baseline in lipid responses for all included studies were calculated using weighted mean differences (WMD) (with 95% confidence interval (CI)). A meta-analysis was conducted to pool results using either the random-effects model or the fixed effects model.Results: A total of 6 publications comprising of 1,686 subjects for the assessment of total cholesterol, LDL-C and HDL-C and 1,156 subjects for the assessment of triglycerides were included in the meta-analyses. Subjects who were non-carriers of a CYP7A1 SNP (−204 A/C (rs3808607), −278 A/C (rs3808607) and rs8192875) had a greater reduction in total cholesterol (overall WMD -0.17, 95% CI -0.29, −0.06) and LDL-C levels (overall WMD -0.16, 95% CI -0.26, −0.05) as compared with subjects who borne the variant allele of CYP7A1 SNPs when administered a statin.Conclusion: The presence of variant allele of CYP7A1 SNPs may result in suboptimal control of total cholesterol and LDL-C levels as compared with individuals who do not carry the variant allele, when administered an equivalent dose of statin.https://www.frontiersin.org/articles/10.3389/fgene.2023.1199549/fullpharmacogenomicsCYP7A1single nucleotide polymorphismsstatinslipid response |
| spellingShingle | Megan Yu Cai Lim Jia Rong Tee Wai-Ping Yau Han Kiat Ho A meta-analysis of the pooled impact of CYP7A1 single nucleotide polymorphisms on serum lipid responses to statins Frontiers in Genetics pharmacogenomics CYP7A1 single nucleotide polymorphisms statins lipid response |
| title | A meta-analysis of the pooled impact of CYP7A1 single nucleotide polymorphisms on serum lipid responses to statins |
| title_full | A meta-analysis of the pooled impact of CYP7A1 single nucleotide polymorphisms on serum lipid responses to statins |
| title_fullStr | A meta-analysis of the pooled impact of CYP7A1 single nucleotide polymorphisms on serum lipid responses to statins |
| title_full_unstemmed | A meta-analysis of the pooled impact of CYP7A1 single nucleotide polymorphisms on serum lipid responses to statins |
| title_short | A meta-analysis of the pooled impact of CYP7A1 single nucleotide polymorphisms on serum lipid responses to statins |
| title_sort | meta analysis of the pooled impact of cyp7a1 single nucleotide polymorphisms on serum lipid responses to statins |
| topic | pharmacogenomics CYP7A1 single nucleotide polymorphisms statins lipid response |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2023.1199549/full |
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