Neuromyelitis optic with positive Anti-AQP4 and Anti-SSA/Ro antibody
Neuromyelitis Optic (NMO) is an inflammatory disorder involving central nervous system which often co-exists with other autoimmune diseases such as Sjögren’s syndrome (SS). NMO manifestation could precede or follow SS, but the role of anti-SSA in the pathogenesis of NMO remains unclear. We present a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-03-01
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| Series: | Neurology International |
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| Online Access: | https://pagepress.org/journals/index.php/ni/article/view/7958 |
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| author | Riwanti Estiasari Salsabila Firdausia Dewi Wulandari Kartika Maharani Freddy Sitorus David Pangeran Darma Imran |
| author_facet | Riwanti Estiasari Salsabila Firdausia Dewi Wulandari Kartika Maharani Freddy Sitorus David Pangeran Darma Imran |
| author_sort | Riwanti Estiasari |
| collection | DOAJ |
| description | Neuromyelitis Optic (NMO) is an inflammatory disorder involving central nervous system which often co-exists with other autoimmune diseases such as Sjögren’s syndrome (SS). NMO manifestation could precede or follow SS, but the role of anti-SSA in the pathogenesis of NMO remains unclear. We present a case of NMO with anti-AQP4 anti-SSA antibody positive. A-44-year-old female presented with right side weakness. The symptoms began with numbness that improved spontaneously. She also complained pain and dry sensations on her eyes. Schirmer test on her left eye, antinuclear antibody (ANA) and anti- SSA antibody were positive. Cervical MRI revealed intramedullary lesion on T2- weighted-image at C2-C5 level. She was diagnosed as NMO with positive anti- AQP4 and probable SS. She received 1g methylprednisolone for 5 days proceeded with mycophenolic acid. One-year observation showed clinical improvement. Systemic autoantibodies must substantially be evaluated in NMO. Comprehensive diagnosis and providing appropriate immunosuppressant might prevent further disability and relapse. |
| first_indexed | 2024-04-10T18:32:04Z |
| format | Article |
| id | doaj.art-72ebcc938a1245d4ab358cf12523f0f9 |
| institution | Directory Open Access Journal |
| issn | 2035-8385 2035-8377 |
| language | English |
| last_indexed | 2024-04-10T18:32:04Z |
| publishDate | 2019-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Neurology International |
| spelling | doaj.art-72ebcc938a1245d4ab358cf12523f0f92023-02-02T03:12:29ZengMDPI AGNeurology International2035-83852035-83772019-03-0111110.4081/ni.2019.7958Neuromyelitis optic with positive Anti-AQP4 and Anti-SSA/Ro antibodyRiwanti Estiasari0Salsabila Firdausia1Dewi Wulandari2Kartika Maharani3Freddy Sitorus4David Pangeran5Darma Imran6Department of Neurology, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo General Hospital, JakartaDepartment of Neurology, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo General Hospital, JakartaDepartment of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo General Hospital, JakartaDepartment of Neurology, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo General Hospital, JakartaDepartment of Neurology, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo General Hospital, JakartaDepartment of Neurology, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo General Hospital, JakartaDepartment of Neurology, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo General Hospital, JakartaNeuromyelitis Optic (NMO) is an inflammatory disorder involving central nervous system which often co-exists with other autoimmune diseases such as Sjögren’s syndrome (SS). NMO manifestation could precede or follow SS, but the role of anti-SSA in the pathogenesis of NMO remains unclear. We present a case of NMO with anti-AQP4 anti-SSA antibody positive. A-44-year-old female presented with right side weakness. The symptoms began with numbness that improved spontaneously. She also complained pain and dry sensations on her eyes. Schirmer test on her left eye, antinuclear antibody (ANA) and anti- SSA antibody were positive. Cervical MRI revealed intramedullary lesion on T2- weighted-image at C2-C5 level. She was diagnosed as NMO with positive anti- AQP4 and probable SS. She received 1g methylprednisolone for 5 days proceeded with mycophenolic acid. One-year observation showed clinical improvement. Systemic autoantibodies must substantially be evaluated in NMO. Comprehensive diagnosis and providing appropriate immunosuppressant might prevent further disability and relapse.https://pagepress.org/journals/index.php/ni/article/view/7958NeuromyelitisOpticSjogrenAQP4Anti-SSA |
| spellingShingle | Riwanti Estiasari Salsabila Firdausia Dewi Wulandari Kartika Maharani Freddy Sitorus David Pangeran Darma Imran Neuromyelitis optic with positive Anti-AQP4 and Anti-SSA/Ro antibody Neurology International Neuromyelitis Optic Sjogren AQP4 Anti-SSA |
| title | Neuromyelitis optic with positive Anti-AQP4 and Anti-SSA/Ro antibody |
| title_full | Neuromyelitis optic with positive Anti-AQP4 and Anti-SSA/Ro antibody |
| title_fullStr | Neuromyelitis optic with positive Anti-AQP4 and Anti-SSA/Ro antibody |
| title_full_unstemmed | Neuromyelitis optic with positive Anti-AQP4 and Anti-SSA/Ro antibody |
| title_short | Neuromyelitis optic with positive Anti-AQP4 and Anti-SSA/Ro antibody |
| title_sort | neuromyelitis optic with positive anti aqp4 and anti ssa ro antibody |
| topic | Neuromyelitis Optic Sjogren AQP4 Anti-SSA |
| url | https://pagepress.org/journals/index.php/ni/article/view/7958 |
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