Plasminogen Activator – Multifunctional Protein of Plague Pathogen
Yersinia pestis plasminogen activator, a surface protease (Pla) is encoded by species-specific plasmid pPla. This enzyme belongs to outer membrane protein family and has a ß-barrel structure. Pla protease interacts complexly with homeostasis system of a hostorganism and is an important factor of pla...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
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Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe”
2016-09-01
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| Series: | Проблемы особо опасных инфекций |
| Subjects: | |
| Online Access: | https://journal.microbe.ru/jour/article/view/319 |
| _version_ | 1797220875377836032 |
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| author | L. M. Kukleva A. V. Boiko |
| author_facet | L. M. Kukleva A. V. Boiko |
| author_sort | L. M. Kukleva |
| collection | DOAJ |
| description | Yersinia pestis plasminogen activator, a surface protease (Pla) is encoded by species-specific plasmid pPla. This enzyme belongs to outer membrane protein family and has a ß-barrel structure. Pla protease interacts complexly with homeostasis system of a hostorganism and is an important factor of plague agent virulence. Represented are the literature data on the part of plasminogen activator in the development of bubonic and pneumonic plague. Described is the role of R-form lipopolysaccharide in protease Pla activity manifestation. Plasminogen activator directly contributes to fibrinolysis by activating plasminogen and inactivating plasminogen-1 activator inhibitor (PAI-1) and ά2-anti-plasmin, as well as promoted by thrombin fibrinolysis inhibitor (TAFI). Pro-coagulant Pla protein activity is caused by the destruction of tissue factor pathway inhibitor (TFPI). In addition, given is the information on non-proteolytic functions of plasminogen activator. |
| first_indexed | 2024-03-08T13:42:23Z |
| format | Article |
| id | doaj.art-72ec41380277451ab1ae2eefe57e9a05 |
| institution | Directory Open Access Journal |
| issn | 0370-1069 2658-719X |
| language | Russian |
| last_indexed | 2024-04-24T12:56:29Z |
| publishDate | 2016-09-01 |
| publisher | Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe” |
| record_format | Article |
| series | Проблемы особо опасных инфекций |
| spelling | doaj.art-72ec41380277451ab1ae2eefe57e9a052024-04-05T16:47:12ZrusFederal Government Health Institution, Russian Research Anti-Plague Institute “Microbe”Проблемы особо опасных инфекций0370-10692658-719X2016-09-0103132010.21055/0370-1069-2016-3-13-20319Plasminogen Activator – Multifunctional Protein of Plague PathogenL. M. Kukleva0A. V. Boiko1Russian Research Anti-Plague Institute “Microbe”Russian Research Anti-Plague Institute “Microbe”Yersinia pestis plasminogen activator, a surface protease (Pla) is encoded by species-specific plasmid pPla. This enzyme belongs to outer membrane protein family and has a ß-barrel structure. Pla protease interacts complexly with homeostasis system of a hostorganism and is an important factor of plague agent virulence. Represented are the literature data on the part of plasminogen activator in the development of bubonic and pneumonic plague. Described is the role of R-form lipopolysaccharide in protease Pla activity manifestation. Plasminogen activator directly contributes to fibrinolysis by activating plasminogen and inactivating plasminogen-1 activator inhibitor (PAI-1) and ά2-anti-plasmin, as well as promoted by thrombin fibrinolysis inhibitor (TAFI). Pro-coagulant Pla protein activity is caused by the destruction of tissue factor pathway inhibitor (TFPI). In addition, given is the information on non-proteolytic functions of plasminogen activator.https://journal.microbe.ru/jour/article/view/319plague agentplasminogen activatorpathogenicity |
| spellingShingle | L. M. Kukleva A. V. Boiko Plasminogen Activator – Multifunctional Protein of Plague Pathogen Проблемы особо опасных инфекций plague agent plasminogen activator pathogenicity |
| title | Plasminogen Activator – Multifunctional Protein of Plague Pathogen |
| title_full | Plasminogen Activator – Multifunctional Protein of Plague Pathogen |
| title_fullStr | Plasminogen Activator – Multifunctional Protein of Plague Pathogen |
| title_full_unstemmed | Plasminogen Activator – Multifunctional Protein of Plague Pathogen |
| title_short | Plasminogen Activator – Multifunctional Protein of Plague Pathogen |
| title_sort | plasminogen activator multifunctional protein of plague pathogen |
| topic | plague agent plasminogen activator pathogenicity |
| url | https://journal.microbe.ru/jour/article/view/319 |
| work_keys_str_mv | AT lmkukleva plasminogenactivatormultifunctionalproteinofplaguepathogen AT avboiko plasminogenactivatormultifunctionalproteinofplaguepathogen |