THE ROLE OF NO SYNTHESIS CORRECTION IN PREVENTION OF CARDIOVASCULAR HYPERTENSIVE REMODELING
Comparative study of preventive effects of two beta-blocking drugs with different mode of action was performed on SHRSP and WKY rats. Morphological and functional parameters – blood pressure, endothelium-dependent vascular relaxation, plasma level of nitric oxide stable metabolites (nitrite/nitrate)...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
«FIRMA «SILICEA» LLC
2002-10-01
|
| Series: | Российский кардиологический журнал |
| Subjects: | |
| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/1906 |
| _version_ | 1797857291893997568 |
|---|---|
| author | V. I. Buvaltsev S. Y. Mashina D. A. Pokidyshev B. V. Smirin L. A. Bayda V. Y. Malyshev E. B. Manukina |
| author_facet | V. I. Buvaltsev S. Y. Mashina D. A. Pokidyshev B. V. Smirin L. A. Bayda V. Y. Malyshev E. B. Manukina |
| author_sort | V. I. Buvaltsev |
| collection | DOAJ |
| description | Comparative study of preventive effects of two beta-blocking drugs with different mode of action was performed on SHRSP and WKY rats. Morphological and functional parameters – blood pressure, endothelium-dependent vascular relaxation, plasma level of nitric oxide stable metabolites (nitrite/nitrate), cardiac hyperthrophy and vascular remodeling were monitored during chronic nebivolol and metoprolol injection in parallel groups of rats. Nebivolol, a cardioselective beta-blocker with ancillary nitric oxide modulating and vasodilating properties exhibited more significant and stable influence on the monitored parameters than metoprolol lacking the nitric oxide modulating activity and more effectively prevented cardiovascular remodeling in experimental hypertension. |
| first_indexed | 2024-04-09T20:55:30Z |
| format | Article |
| id | doaj.art-72ec9c6c38cf488899983c2f5e5a86a6 |
| institution | Directory Open Access Journal |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| last_indexed | 2024-04-09T20:55:30Z |
| publishDate | 2002-10-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj.art-72ec9c6c38cf488899983c2f5e5a86a62023-03-29T21:23:10Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202002-10-010574811666THE ROLE OF NO SYNTHESIS CORRECTION IN PREVENTION OF CARDIOVASCULAR HYPERTENSIVE REMODELINGV. I. Buvaltsev0S. Y. Mashina1D. A. Pokidyshev2B. V. Smirin3L. A. Bayda4V. Y. Malyshev5E. B. Manukina6Научно-исследовательский институт общей патологии и патофизиологии РАМННаучно-исследовательский институт общей патологии и патофизиологии РАМННаучно-исследовательский институт общей патологии и патофизиологии РАМННаучно-исследовательский институт общей патологии и патофизиологии РАМННаучно-исследовательский институт общей патологии и патофизиологии РАМННаучно-исследовательский институт общей патологии и патофизиологии РАМННаучно-исследовательский институт общей патологии и патофизиологии РАМНComparative study of preventive effects of two beta-blocking drugs with different mode of action was performed on SHRSP and WKY rats. Morphological and functional parameters – blood pressure, endothelium-dependent vascular relaxation, plasma level of nitric oxide stable metabolites (nitrite/nitrate), cardiac hyperthrophy and vascular remodeling were monitored during chronic nebivolol and metoprolol injection in parallel groups of rats. Nebivolol, a cardioselective beta-blocker with ancillary nitric oxide modulating and vasodilating properties exhibited more significant and stable influence on the monitored parameters than metoprolol lacking the nitric oxide modulating activity and more effectively prevented cardiovascular remodeling in experimental hypertension.https://russjcardiol.elpub.ru/jour/article/view/1906arterial hypertensionnebivololnitriс oxidecardiovascular remodeling |
| spellingShingle | V. I. Buvaltsev S. Y. Mashina D. A. Pokidyshev B. V. Smirin L. A. Bayda V. Y. Malyshev E. B. Manukina THE ROLE OF NO SYNTHESIS CORRECTION IN PREVENTION OF CARDIOVASCULAR HYPERTENSIVE REMODELING Российский кардиологический журнал arterial hypertension nebivolol nitriс oxide cardiovascular remodeling |
| title | THE ROLE OF NO SYNTHESIS CORRECTION IN PREVENTION OF CARDIOVASCULAR HYPERTENSIVE REMODELING |
| title_full | THE ROLE OF NO SYNTHESIS CORRECTION IN PREVENTION OF CARDIOVASCULAR HYPERTENSIVE REMODELING |
| title_fullStr | THE ROLE OF NO SYNTHESIS CORRECTION IN PREVENTION OF CARDIOVASCULAR HYPERTENSIVE REMODELING |
| title_full_unstemmed | THE ROLE OF NO SYNTHESIS CORRECTION IN PREVENTION OF CARDIOVASCULAR HYPERTENSIVE REMODELING |
| title_short | THE ROLE OF NO SYNTHESIS CORRECTION IN PREVENTION OF CARDIOVASCULAR HYPERTENSIVE REMODELING |
| title_sort | role of no synthesis correction in prevention of cardiovascular hypertensive remodeling |
| topic | arterial hypertension nebivolol nitriс oxide cardiovascular remodeling |
| url | https://russjcardiol.elpub.ru/jour/article/view/1906 |
| work_keys_str_mv | AT vibuvaltsev theroleofnosynthesiscorrectioninpreventionofcardiovascularhypertensiveremodeling AT symashina theroleofnosynthesiscorrectioninpreventionofcardiovascularhypertensiveremodeling AT dapokidyshev theroleofnosynthesiscorrectioninpreventionofcardiovascularhypertensiveremodeling AT bvsmirin theroleofnosynthesiscorrectioninpreventionofcardiovascularhypertensiveremodeling AT labayda theroleofnosynthesiscorrectioninpreventionofcardiovascularhypertensiveremodeling AT vymalyshev theroleofnosynthesiscorrectioninpreventionofcardiovascularhypertensiveremodeling AT ebmanukina theroleofnosynthesiscorrectioninpreventionofcardiovascularhypertensiveremodeling AT vibuvaltsev roleofnosynthesiscorrectioninpreventionofcardiovascularhypertensiveremodeling AT symashina roleofnosynthesiscorrectioninpreventionofcardiovascularhypertensiveremodeling AT dapokidyshev roleofnosynthesiscorrectioninpreventionofcardiovascularhypertensiveremodeling AT bvsmirin roleofnosynthesiscorrectioninpreventionofcardiovascularhypertensiveremodeling AT labayda roleofnosynthesiscorrectioninpreventionofcardiovascularhypertensiveremodeling AT vymalyshev roleofnosynthesiscorrectioninpreventionofcardiovascularhypertensiveremodeling AT ebmanukina roleofnosynthesiscorrectioninpreventionofcardiovascularhypertensiveremodeling |