Identification of a binding site on soluble RANKL that can be targeted to inhibit soluble RANK-RANKL interactions and treat osteoporosis
Huang et al. discover a binding site on soluble RANKL that is not found on its membrane-bound homologue. A drug screening identified a small molecule (S3-15) that can target this binding site and has anti-osteoporotic but not immunosuppressive effects.
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-33006-4 |
| _version_ | 1811267511912497152 |
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| author | Dane Huang Chao Zhao Ruyue Li Bingyi Chen Yuting Zhang Zhejun Sun Junkang Wei Huihao Zhou Qiong Gu Jun Xu |
| author_facet | Dane Huang Chao Zhao Ruyue Li Bingyi Chen Yuting Zhang Zhejun Sun Junkang Wei Huihao Zhou Qiong Gu Jun Xu |
| author_sort | Dane Huang |
| collection | DOAJ |
| description | Huang et al. discover a binding site on soluble RANKL that is not found on its membrane-bound homologue. A drug screening identified a small molecule (S3-15) that can target this binding site and has anti-osteoporotic but not immunosuppressive effects. |
| first_indexed | 2024-04-12T21:04:53Z |
| format | Article |
| id | doaj.art-72ed5536113e4557af499911ac1cabd6 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T21:04:53Z |
| publishDate | 2022-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-72ed5536113e4557af499911ac1cabd62022-12-22T03:16:45ZengNature PortfolioNature Communications2041-17232022-09-0113111810.1038/s41467-022-33006-4Identification of a binding site on soluble RANKL that can be targeted to inhibit soluble RANK-RANKL interactions and treat osteoporosisDane Huang0Chao Zhao1Ruyue Li2Bingyi Chen3Yuting Zhang4Zhejun Sun5Junkang Wei6Huihao Zhou7Qiong Gu8Jun Xu9Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen UniversityResearch Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen UniversityGuangdong Provincial Key Laboratory of Research and Development in Traditional Chinese Medicine, Guangdong Provincial Second Hospital of Traditional Chinese Medicine (Guangdong Provincial Engineering Technology Research Institute of Traditional Chinese Medicine)Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen UniversityResearch Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen UniversityResearch Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen UniversityResearch Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen UniversityResearch Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen UniversityResearch Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen UniversityResearch Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen UniversityHuang et al. discover a binding site on soluble RANKL that is not found on its membrane-bound homologue. A drug screening identified a small molecule (S3-15) that can target this binding site and has anti-osteoporotic but not immunosuppressive effects.https://doi.org/10.1038/s41467-022-33006-4 |
| spellingShingle | Dane Huang Chao Zhao Ruyue Li Bingyi Chen Yuting Zhang Zhejun Sun Junkang Wei Huihao Zhou Qiong Gu Jun Xu Identification of a binding site on soluble RANKL that can be targeted to inhibit soluble RANK-RANKL interactions and treat osteoporosis Nature Communications |
| title | Identification of a binding site on soluble RANKL that can be targeted to inhibit soluble RANK-RANKL interactions and treat osteoporosis |
| title_full | Identification of a binding site on soluble RANKL that can be targeted to inhibit soluble RANK-RANKL interactions and treat osteoporosis |
| title_fullStr | Identification of a binding site on soluble RANKL that can be targeted to inhibit soluble RANK-RANKL interactions and treat osteoporosis |
| title_full_unstemmed | Identification of a binding site on soluble RANKL that can be targeted to inhibit soluble RANK-RANKL interactions and treat osteoporosis |
| title_short | Identification of a binding site on soluble RANKL that can be targeted to inhibit soluble RANK-RANKL interactions and treat osteoporosis |
| title_sort | identification of a binding site on soluble rankl that can be targeted to inhibit soluble rank rankl interactions and treat osteoporosis |
| url | https://doi.org/10.1038/s41467-022-33006-4 |
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