Low levels of free triiodothyronine are associated with risk of cognitive impairment in older euthyroid adults
Abstract Accumulated evidence showed that thyroid diseases induced cognitive decline. However, the relationship between thyroid hormones (THs) and cognition in older euthyroid people is still unclear. Our study aimed to estimate the association between THs within the euthyroid range and cognition in...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-12-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-49285-w |
| _version_ | 1797388346767441920 |
|---|---|
| author | Hao Chen Jin Hu Xing Yang Quanxiang Zhou Yuxin Hu Xiaoyan Tang Ji Tang Li Zeng Jingyuan Yang |
| author_facet | Hao Chen Jin Hu Xing Yang Quanxiang Zhou Yuxin Hu Xiaoyan Tang Ji Tang Li Zeng Jingyuan Yang |
| author_sort | Hao Chen |
| collection | DOAJ |
| description | Abstract Accumulated evidence showed that thyroid diseases induced cognitive decline. However, the relationship between thyroid hormones (THs) and cognition in older euthyroid people is still unclear. Our study aimed to estimate the association between THs within the euthyroid range and cognition in community-dwelling older adults in China. Data were extracted from a cohort study on the health status of rural older adults from the Guizhou province in China (HSRO). Serum thyroid-stimulating hormone (TSH), free thyroxine (FT4), and free triiodothyronine (FT3) were measured using the electrochemiluminescence immunoassay. Cognitive function was evaluated by the Mini-Mental State Examination (MMSE). Linear regression and a binary logistic regression model were used to explore the relationship between THs and cognition in euthyroidism (TSH level of 0.27 ~ 4.20mIU/L). A total of 957 euthyroidism individuals were included in this study, with a mean (SD) age of 71.34 (6.35) years. In individuals with euthyroidism, serum TSH and FT3 levels were positively associated with cognition (TSH:β = 0.06, 95% CI 0.01 ~ 0.11, P = 0.03; FT 3 :β = 0.07, 95% CI 0.01 ~ 0.12, P = 0.01); and serum FT3 and TSH levels were significantly associated with cognitive domains (P < 0.05). Further, euthyroid individuals in the lowest serum FT3(OR = 1.96; 95% CI 1.27 ~ 3.03) quartile had a twofold increased risk of cognitive impairment compared to those in the highest quartile after adjusting for potential confounding factors. These findings suggested that low levels of FT3 could be an independent risk factor for cognitive impairment in older euthyroid adults. Additionally, a positive linear association exists between serum FT3 levels and cognitive domains (such as immediate memory, language, and attention). Further studies are needed to determine the underlying mechanisms and the community significance of these findings. |
| first_indexed | 2024-03-08T22:38:26Z |
| format | Article |
| id | doaj.art-72f0d1a47d0844a8ac5254e8937234cb |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-08T22:38:26Z |
| publishDate | 2023-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-72f0d1a47d0844a8ac5254e8937234cb2023-12-17T12:17:40ZengNature PortfolioScientific Reports2045-23222023-12-011311810.1038/s41598-023-49285-wLow levels of free triiodothyronine are associated with risk of cognitive impairment in older euthyroid adultsHao Chen0Jin Hu1Xing Yang2Quanxiang Zhou3Yuxin Hu4Xiaoyan Tang5Ji Tang6Li Zeng7Jingyuan Yang8Department of Epidemiology and Health Statistics, School of Public Health, The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Guizhou Medical UniversityDepartment of Epidemiology and Health Statistics, School of Public Health, The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Guizhou Medical UniversitySchool of Medicine and Health Management, Guizhou Medical UniversityDepartment of Clinical Medicine, Qinnan Medical College for NationalitiesDepartment of Epidemiology and Health Statistics, School of Public Health, The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Guizhou Medical UniversityDepartment of Epidemiology and Health Statistics, School of Public Health, The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Guizhou Medical UniversityDepartment of Epidemiology and Health Statistics, School of Public Health, The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Guizhou Medical UniversityDepartment of Epidemiology and Health Statistics, School of Public Health, The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Guizhou Medical UniversityDepartment of Epidemiology and Health Statistics, School of Public Health, The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Guizhou Medical UniversityAbstract Accumulated evidence showed that thyroid diseases induced cognitive decline. However, the relationship between thyroid hormones (THs) and cognition in older euthyroid people is still unclear. Our study aimed to estimate the association between THs within the euthyroid range and cognition in community-dwelling older adults in China. Data were extracted from a cohort study on the health status of rural older adults from the Guizhou province in China (HSRO). Serum thyroid-stimulating hormone (TSH), free thyroxine (FT4), and free triiodothyronine (FT3) were measured using the electrochemiluminescence immunoassay. Cognitive function was evaluated by the Mini-Mental State Examination (MMSE). Linear regression and a binary logistic regression model were used to explore the relationship between THs and cognition in euthyroidism (TSH level of 0.27 ~ 4.20mIU/L). A total of 957 euthyroidism individuals were included in this study, with a mean (SD) age of 71.34 (6.35) years. In individuals with euthyroidism, serum TSH and FT3 levels were positively associated with cognition (TSH:β = 0.06, 95% CI 0.01 ~ 0.11, P = 0.03; FT 3 :β = 0.07, 95% CI 0.01 ~ 0.12, P = 0.01); and serum FT3 and TSH levels were significantly associated with cognitive domains (P < 0.05). Further, euthyroid individuals in the lowest serum FT3(OR = 1.96; 95% CI 1.27 ~ 3.03) quartile had a twofold increased risk of cognitive impairment compared to those in the highest quartile after adjusting for potential confounding factors. These findings suggested that low levels of FT3 could be an independent risk factor for cognitive impairment in older euthyroid adults. Additionally, a positive linear association exists between serum FT3 levels and cognitive domains (such as immediate memory, language, and attention). Further studies are needed to determine the underlying mechanisms and the community significance of these findings.https://doi.org/10.1038/s41598-023-49285-w |
| spellingShingle | Hao Chen Jin Hu Xing Yang Quanxiang Zhou Yuxin Hu Xiaoyan Tang Ji Tang Li Zeng Jingyuan Yang Low levels of free triiodothyronine are associated with risk of cognitive impairment in older euthyroid adults Scientific Reports |
| title | Low levels of free triiodothyronine are associated with risk of cognitive impairment in older euthyroid adults |
| title_full | Low levels of free triiodothyronine are associated with risk of cognitive impairment in older euthyroid adults |
| title_fullStr | Low levels of free triiodothyronine are associated with risk of cognitive impairment in older euthyroid adults |
| title_full_unstemmed | Low levels of free triiodothyronine are associated with risk of cognitive impairment in older euthyroid adults |
| title_short | Low levels of free triiodothyronine are associated with risk of cognitive impairment in older euthyroid adults |
| title_sort | low levels of free triiodothyronine are associated with risk of cognitive impairment in older euthyroid adults |
| url | https://doi.org/10.1038/s41598-023-49285-w |
| work_keys_str_mv | AT haochen lowlevelsoffreetriiodothyronineareassociatedwithriskofcognitiveimpairmentinoldereuthyroidadults AT jinhu lowlevelsoffreetriiodothyronineareassociatedwithriskofcognitiveimpairmentinoldereuthyroidadults AT xingyang lowlevelsoffreetriiodothyronineareassociatedwithriskofcognitiveimpairmentinoldereuthyroidadults AT quanxiangzhou lowlevelsoffreetriiodothyronineareassociatedwithriskofcognitiveimpairmentinoldereuthyroidadults AT yuxinhu lowlevelsoffreetriiodothyronineareassociatedwithriskofcognitiveimpairmentinoldereuthyroidadults AT xiaoyantang lowlevelsoffreetriiodothyronineareassociatedwithriskofcognitiveimpairmentinoldereuthyroidadults AT jitang lowlevelsoffreetriiodothyronineareassociatedwithriskofcognitiveimpairmentinoldereuthyroidadults AT lizeng lowlevelsoffreetriiodothyronineareassociatedwithriskofcognitiveimpairmentinoldereuthyroidadults AT jingyuanyang lowlevelsoffreetriiodothyronineareassociatedwithriskofcognitiveimpairmentinoldereuthyroidadults |