THE ROLE OF BIFIDOBACTERIA IN THE FORMATION OF HUMAN IMMUNE HOMEOSTASIS
In the review the materials on the formation ofintestinal immune homeostasis through involvement of bifidobacteria which are the key species of microbiota of human colon biotype are presented. Key function of dominant microorganisms, bifidoflora in particular, in intestinal biotype of a host is carr...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Central Research Institute for Epidemiology
2015-12-01
|
| Series: | Журнал микробиологии, эпидемиологии и иммунобиологии |
| Subjects: | |
| Online Access: | https://microbiol.crie.ru/jour/article/view/14159 |
| _version_ | 1827903068810772480 |
|---|---|
| author | O. V Bukharin E. V Ivanova N. B Perunova I. N Chainikova |
| author_facet | O. V Bukharin E. V Ivanova N. B Perunova I. N Chainikova |
| author_sort | O. V Bukharin |
| collection | DOAJ |
| description | In the review the materials on the formation ofintestinal immune homeostasis through involvement of bifidobacteria which are the key species of microbiota of human colon biotype are presented. Key function of dominant microorganisms, bifidoflora in particular, in intestinal biotype of a host is carried out by means of maintenance of self microorganisms and pronounced antagonism concerning non-self. Realization of this principle in intermicrobial relations allowed to develop algorithm of microbial self-non-self discrimination in microsymbiocenosis on the basis of detected opposite phenomenon (en-hancement/suppression) of the main physiological functions of microsymbionts survival (reproduction and adaptation) in dominant-associant pair. Primary discrimination of foreign material by bifidobacteria is the initial stage of the following «signaling» in the regulation of host immune homeostasis. Further stages of regulation occur by activation of dendritic cells by bifidobacteria with the sequential influence on differentiation of Th0 towards regulatory lymphocytes. The formation of Treg and regulation of immune homeostasis are carried out by bifidobacteria: due to direct activation of dendritic cells (ligand-receptor interactions) and maintenance of optimal cytokine balance. |
| first_indexed | 2024-03-13T00:07:47Z |
| format | Article |
| id | doaj.art-72f27ba635214b899147cdb0e4541290 |
| institution | Directory Open Access Journal |
| issn | 0372-9311 2686-7613 |
| language | Russian |
| last_indexed | 2024-03-13T00:07:47Z |
| publishDate | 2015-12-01 |
| publisher | Central Research Institute for Epidemiology |
| record_format | Article |
| series | Журнал микробиологии, эпидемиологии и иммунобиологии |
| spelling | doaj.art-72f27ba635214b899147cdb0e45412902023-07-12T20:21:14ZrusCentral Research Institute for EpidemiologyЖурнал микробиологии, эпидемиологии и иммунобиологии0372-93112686-76132015-12-01926981042584THE ROLE OF BIFIDOBACTERIA IN THE FORMATION OF HUMAN IMMUNE HOMEOSTASISO. V Bukharin0E. V Ivanova1N. B Perunova2I. N Chainikova3Institute for Cellular and Intracellular SymbiosisInstitute for Cellular and Intracellular SymbiosisInstitute for Cellular and Intracellular SymbiosisInstitute for Cellular and Intracellular SymbiosisIn the review the materials on the formation ofintestinal immune homeostasis through involvement of bifidobacteria which are the key species of microbiota of human colon biotype are presented. Key function of dominant microorganisms, bifidoflora in particular, in intestinal biotype of a host is carried out by means of maintenance of self microorganisms and pronounced antagonism concerning non-self. Realization of this principle in intermicrobial relations allowed to develop algorithm of microbial self-non-self discrimination in microsymbiocenosis on the basis of detected opposite phenomenon (en-hancement/suppression) of the main physiological functions of microsymbionts survival (reproduction and adaptation) in dominant-associant pair. Primary discrimination of foreign material by bifidobacteria is the initial stage of the following «signaling» in the regulation of host immune homeostasis. Further stages of regulation occur by activation of dendritic cells by bifidobacteria with the sequential influence on differentiation of Th0 towards regulatory lymphocytes. The formation of Treg and regulation of immune homeostasis are carried out by bifidobacteria: due to direct activation of dendritic cells (ligand-receptor interactions) and maintenance of optimal cytokine balance.https://microbiol.crie.ru/jour/article/view/14159bifidobacteriaimmune homeostasismicrobial self-non-self discriminationdendritic cellscytokine |
| spellingShingle | O. V Bukharin E. V Ivanova N. B Perunova I. N Chainikova THE ROLE OF BIFIDOBACTERIA IN THE FORMATION OF HUMAN IMMUNE HOMEOSTASIS Журнал микробиологии, эпидемиологии и иммунобиологии bifidobacteria immune homeostasis microbial self-non-self discrimination dendritic cells cytokine |
| title | THE ROLE OF BIFIDOBACTERIA IN THE FORMATION OF HUMAN IMMUNE HOMEOSTASIS |
| title_full | THE ROLE OF BIFIDOBACTERIA IN THE FORMATION OF HUMAN IMMUNE HOMEOSTASIS |
| title_fullStr | THE ROLE OF BIFIDOBACTERIA IN THE FORMATION OF HUMAN IMMUNE HOMEOSTASIS |
| title_full_unstemmed | THE ROLE OF BIFIDOBACTERIA IN THE FORMATION OF HUMAN IMMUNE HOMEOSTASIS |
| title_short | THE ROLE OF BIFIDOBACTERIA IN THE FORMATION OF HUMAN IMMUNE HOMEOSTASIS |
| title_sort | role of bifidobacteria in the formation of human immune homeostasis |
| topic | bifidobacteria immune homeostasis microbial self-non-self discrimination dendritic cells cytokine |
| url | https://microbiol.crie.ru/jour/article/view/14159 |
| work_keys_str_mv | AT ovbukharin theroleofbifidobacteriaintheformationofhumanimmunehomeostasis AT evivanova theroleofbifidobacteriaintheformationofhumanimmunehomeostasis AT nbperunova theroleofbifidobacteriaintheformationofhumanimmunehomeostasis AT inchainikova theroleofbifidobacteriaintheformationofhumanimmunehomeostasis AT ovbukharin roleofbifidobacteriaintheformationofhumanimmunehomeostasis AT evivanova roleofbifidobacteriaintheformationofhumanimmunehomeostasis AT nbperunova roleofbifidobacteriaintheformationofhumanimmunehomeostasis AT inchainikova roleofbifidobacteriaintheformationofhumanimmunehomeostasis |