HSP90 Modulates T2R Bitter Taste Receptor Nitric Oxide Production and Innate Immune Responses in Human Airway Epithelial Cells and Macrophages

HSP90 Modulates T2R Bitter Taste Receptor Nitric Oxide Production and Innate Immune Responses in Human Airway Epithelial Cells and Macrophages

Bitter taste receptors (T2Rs) are G protein-coupled receptors (GPCRs) expressed in various cell types including ciliated airway epithelial cells and macrophages. T2Rs in these two innate immune cell types are activated by bitter products, including those secreted by <i>Pseudomonas aeruginosa&l...

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Bibliographic Details
Main Authors: Ryan M. Carey, Benjamin M. Hariri, Nithin D. Adappa, James N. Palmer, Robert J. Lee
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Cells
Subjects:
bitter taste receptors
macrophages
airway epithelium
nitric oxide
calcium
cilia
Online Access:https://www.mdpi.com/2073-4409/11/9/1478

Internet

https://www.mdpi.com/2073-4409/11/9/1478

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