Molecular and functional profiling of chemotolerant cells unveils nucleoside metabolism-dependent vulnerabilities in medulloblastoma

Molecular and functional profiling of chemotolerant cells unveils nucleoside metabolism-dependent vulnerabilities in medulloblastoma

Abstract Chemotherapy resistance is considered one of the main causes of tumor relapse, still challenging researchers for the identification of the molecular mechanisms sustaining its emergence. Here, we setup and characterized chemotherapy-resistant models of Medulloblastoma (MB), one of the most l...

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Bibliographic Details
Main Authors: Elena Mariotto, Elena Rampazzo, Roberta Bortolozzi, Fatlum Rruga, Ilaria Zeni, Lorenzo Manfreda, Chiara Marchioro, Martina Canton, Alice Cani, Ruben Magni, Alessandra Luchini, Silvia Bresolin, Giampietro Viola, Luca Persano
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Acta Neuropathologica Communications
Subjects:
Chemotherapy resistance
Medulloblastoma
High throughput drug screening
Antimetabolites
Online Access:https://doi.org/10.1186/s40478-023-01679-7

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