Diagnostic accuracy of calprotectin in periprosthetic joint infection: a diagnostic meta-analysis
Abstract Background Periprosthetic joint infection (PJI) is considered to be one of the most challenging complications of joint replacement, which remains unpredictable. As a simple and emerging biomarker, calprotectin (CLP) has been considered to be useful in ruling out PJI in recent years. The pur...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-01-01
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| Series: | Journal of Orthopaedic Surgery and Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13018-021-02895-4 |
| _version_ | 1828155069027057664 |
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| author | Jisi Xing Jiahao Li Zijian Yan Yijin Li Xiaofang Liu Lilei He Ting Xu Changbing Wang Lilian Zhao Ke Jie |
| author_facet | Jisi Xing Jiahao Li Zijian Yan Yijin Li Xiaofang Liu Lilei He Ting Xu Changbing Wang Lilian Zhao Ke Jie |
| author_sort | Jisi Xing |
| collection | DOAJ |
| description | Abstract Background Periprosthetic joint infection (PJI) is considered to be one of the most challenging complications of joint replacement, which remains unpredictable. As a simple and emerging biomarker, calprotectin (CLP) has been considered to be useful in ruling out PJI in recent years. The purpose of this study was to investigate the accuracy and sensitivity of CLP in the diagnosis of PJI. Methods We searched and screened the publications from PubMed, Web of Science, EMBASE, and Cochrane Library from database establishment to June 2021. Subsequently, Stata version 16.0 software was used to combine the pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), operating characteristic curve, and area under the curve (AUC). Heterogeneity across articles was evaluated by the I2 statistics. Finally, sources of heterogeneity were detected by subgroup analysis based on study design, detection method, sample size, and cutoff values. Results A total of 7 studies were included in our study, comprising 525 patients. The pooled sensitivity, specificity, PLR, and NLR of CLP for PJI diagnosis were 0.94(95% CI 0.87–0.98), 0.93(95% CI 0.87–0.96), 13.65(95% CI 6.89–27.08), and 0.06(95% CI 0.02–0.15), respectively, while the DOR and AUC were 222.33(95% CI 52.52–941.11) and 0.98 (95% CI 0.96–0.99), respectively. Conclusion Synovial CLP is a reliable biomarker and can be used as a diagnostic criterion for PJI in the future. However, the uncertainty resulting from the poor study numbers and sample sizes limit our ability to definitely draw conclusions on the basis of our study. |
| first_indexed | 2024-04-11T22:48:04Z |
| format | Article |
| id | doaj.art-72f6439badd245a086547412cc7224f7 |
| institution | Directory Open Access Journal |
| issn | 1749-799X |
| language | English |
| last_indexed | 2024-04-11T22:48:04Z |
| publishDate | 2022-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj.art-72f6439badd245a086547412cc7224f72022-12-22T03:58:41ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2022-01-0117111210.1186/s13018-021-02895-4Diagnostic accuracy of calprotectin in periprosthetic joint infection: a diagnostic meta-analysisJisi Xing0Jiahao Li1Zijian Yan2Yijin Li3Xiaofang Liu4Lilei He5Ting Xu6Changbing Wang7Lilian Zhao8Ke Jie9Foshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese Medicine, Foshan Hospital of Traditional Chinese MedicineThe First Clinical Medical School, Guangzhou University of Chinese MedicineThe First Clinical Medical School, Guangzhou University of Chinese MedicineThe First Clinical Medical School, Guangzhou University of Chinese MedicineFoshan Hospital of Traditional Chinese MedicineFoshan Hospital of Traditional Chinese MedicineFoshan Hospital of Traditional Chinese MedicineFoshan Hospital of Traditional Chinese MedicineFoshan Hospital of Traditional Chinese MedicineFoshan Hospital of Traditional Chinese MedicineAbstract Background Periprosthetic joint infection (PJI) is considered to be one of the most challenging complications of joint replacement, which remains unpredictable. As a simple and emerging biomarker, calprotectin (CLP) has been considered to be useful in ruling out PJI in recent years. The purpose of this study was to investigate the accuracy and sensitivity of CLP in the diagnosis of PJI. Methods We searched and screened the publications from PubMed, Web of Science, EMBASE, and Cochrane Library from database establishment to June 2021. Subsequently, Stata version 16.0 software was used to combine the pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), operating characteristic curve, and area under the curve (AUC). Heterogeneity across articles was evaluated by the I2 statistics. Finally, sources of heterogeneity were detected by subgroup analysis based on study design, detection method, sample size, and cutoff values. Results A total of 7 studies were included in our study, comprising 525 patients. The pooled sensitivity, specificity, PLR, and NLR of CLP for PJI diagnosis were 0.94(95% CI 0.87–0.98), 0.93(95% CI 0.87–0.96), 13.65(95% CI 6.89–27.08), and 0.06(95% CI 0.02–0.15), respectively, while the DOR and AUC were 222.33(95% CI 52.52–941.11) and 0.98 (95% CI 0.96–0.99), respectively. Conclusion Synovial CLP is a reliable biomarker and can be used as a diagnostic criterion for PJI in the future. However, the uncertainty resulting from the poor study numbers and sample sizes limit our ability to definitely draw conclusions on the basis of our study.https://doi.org/10.1186/s13018-021-02895-4CalprotectinDiagnosisPeriprosthetic joint infectionMeta-analysis |
| spellingShingle | Jisi Xing Jiahao Li Zijian Yan Yijin Li Xiaofang Liu Lilei He Ting Xu Changbing Wang Lilian Zhao Ke Jie Diagnostic accuracy of calprotectin in periprosthetic joint infection: a diagnostic meta-analysis Journal of Orthopaedic Surgery and Research Calprotectin Diagnosis Periprosthetic joint infection Meta-analysis |
| title | Diagnostic accuracy of calprotectin in periprosthetic joint infection: a diagnostic meta-analysis |
| title_full | Diagnostic accuracy of calprotectin in periprosthetic joint infection: a diagnostic meta-analysis |
| title_fullStr | Diagnostic accuracy of calprotectin in periprosthetic joint infection: a diagnostic meta-analysis |
| title_full_unstemmed | Diagnostic accuracy of calprotectin in periprosthetic joint infection: a diagnostic meta-analysis |
| title_short | Diagnostic accuracy of calprotectin in periprosthetic joint infection: a diagnostic meta-analysis |
| title_sort | diagnostic accuracy of calprotectin in periprosthetic joint infection a diagnostic meta analysis |
| topic | Calprotectin Diagnosis Periprosthetic joint infection Meta-analysis |
| url | https://doi.org/10.1186/s13018-021-02895-4 |
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