Elevated Endothelin-1 in Intradialytic Hypertension
Objective: To determine the relative change in endothelin-1 (ET-1) during hemodialysis procedure in Stage Five Dialysis-Dependent Chronic Kidney Disease (CKD-5D)patients with and without intradialytic hypertension (IDH). Methods: This was a cross-sectional, observational study involving 40 CKD-5D pa...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Universitas Padjadjaran
2019-09-01
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| Series: | International Journal of Integrated Health Sciences |
| Subjects: | |
| Online Access: | http://journal.fk.unpad.ac.id/index.php/ijihs/article/view/1737 |
| _version_ | 1818218585957335040 |
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| author | Rubin Surachno Gondodiputro Andika Wiratama Stefanie Yuliana Usman Erma Arnika Dewi Evan Susandi Afiatin Afiatin Ria Bandiara |
| author_facet | Rubin Surachno Gondodiputro Andika Wiratama Stefanie Yuliana Usman Erma Arnika Dewi Evan Susandi Afiatin Afiatin Ria Bandiara |
| author_sort | Rubin Surachno Gondodiputro |
| collection | DOAJ |
| description | Objective: To determine the relative change in endothelin-1 (ET-1) during hemodialysis procedure in Stage Five Dialysis-Dependent Chronic Kidney Disease (CKD-5D)patients with and without intradialytic hypertension (IDH).
Methods: This was a cross-sectional, observational study involving 40 CKD-5D patients who received two hemodialysis per week for at least three months at the dialysis unit of Dr. Hasan Sadikin Hospital General Bandung, Indonesia during September 2016. Subjects were divided two groups: with IDH (n=20) and without IDH (n=20). Plasma ET-1 level was examined before and after hemodialysis.
Results: There was a significant elevation of ET-1 level (mean±SD pg/mL) between pre- and post-dialysis state in patients with IDH (3.33±1.28 vs. 3.84±1.75; relative changes: 15.32%, p=0.013). No change was observed in patients without IDH (3.99±2.30 vs. 4.38±1.81; relative changes: 9.77% p=0.083). The post-dialysis absolute ET-1 level was significantly lower in CKD-5D patients with IDH (3.84±1.75 vs. 4.38±1.81; p=0.024).
Conclusion: There was a significant elevation of ET-1 level in CKD-5D patients with IDH during hemodialysis procedure at the dialysis unit of Dr. Hasan Sadikin General Hospital Bandung. |
| first_indexed | 2024-12-12T07:26:07Z |
| format | Article |
| id | doaj.art-72f895eccfc641f6836bb7e4a6287aa0 |
| institution | Directory Open Access Journal |
| issn | 2302-1381 2338-4506 |
| language | English |
| last_indexed | 2024-12-12T07:26:07Z |
| publishDate | 2019-09-01 |
| publisher | Universitas Padjadjaran |
| record_format | Article |
| series | International Journal of Integrated Health Sciences |
| spelling | doaj.art-72f895eccfc641f6836bb7e4a6287aa02022-12-22T00:33:09ZengUniversitas PadjadjaranInternational Journal of Integrated Health Sciences2302-13812338-45062019-09-017210210710.15850/ijihs.v7n2.17371221Elevated Endothelin-1 in Intradialytic HypertensionRubin Surachno Gondodiputro0Andika Wiratama1Stefanie Yuliana Usman2Erma Arnika Dewi3Evan Susandi4Afiatin Afiatin5Ria Bandiara6Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin HospitalDepartment of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin HospitalDepartment of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin HospitalDepartment of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin HospitalDepartment of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin HospitalDepartment of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin HospitalDepartment of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin HospitalObjective: To determine the relative change in endothelin-1 (ET-1) during hemodialysis procedure in Stage Five Dialysis-Dependent Chronic Kidney Disease (CKD-5D)patients with and without intradialytic hypertension (IDH). Methods: This was a cross-sectional, observational study involving 40 CKD-5D patients who received two hemodialysis per week for at least three months at the dialysis unit of Dr. Hasan Sadikin Hospital General Bandung, Indonesia during September 2016. Subjects were divided two groups: with IDH (n=20) and without IDH (n=20). Plasma ET-1 level was examined before and after hemodialysis. Results: There was a significant elevation of ET-1 level (mean±SD pg/mL) between pre- and post-dialysis state in patients with IDH (3.33±1.28 vs. 3.84±1.75; relative changes: 15.32%, p=0.013). No change was observed in patients without IDH (3.99±2.30 vs. 4.38±1.81; relative changes: 9.77% p=0.083). The post-dialysis absolute ET-1 level was significantly lower in CKD-5D patients with IDH (3.84±1.75 vs. 4.38±1.81; p=0.024). Conclusion: There was a significant elevation of ET-1 level in CKD-5D patients with IDH during hemodialysis procedure at the dialysis unit of Dr. Hasan Sadikin General Hospital Bandung.http://journal.fk.unpad.ac.id/index.php/ijihs/article/view/1737endothelin-1hemodialysisintradialytic hypertension |
| spellingShingle | Rubin Surachno Gondodiputro Andika Wiratama Stefanie Yuliana Usman Erma Arnika Dewi Evan Susandi Afiatin Afiatin Ria Bandiara Elevated Endothelin-1 in Intradialytic Hypertension International Journal of Integrated Health Sciences endothelin-1 hemodialysis intradialytic hypertension |
| title | Elevated Endothelin-1 in Intradialytic Hypertension |
| title_full | Elevated Endothelin-1 in Intradialytic Hypertension |
| title_fullStr | Elevated Endothelin-1 in Intradialytic Hypertension |
| title_full_unstemmed | Elevated Endothelin-1 in Intradialytic Hypertension |
| title_short | Elevated Endothelin-1 in Intradialytic Hypertension |
| title_sort | elevated endothelin 1 in intradialytic hypertension |
| topic | endothelin-1 hemodialysis intradialytic hypertension |
| url | http://journal.fk.unpad.ac.id/index.php/ijihs/article/view/1737 |
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