Loss of exosomal micro-RNA-200b-3p from hypoxia cancer-associated fibroblasts reduces sensitivity to 5-flourouracil in colorectal cancer through targeting high-mobility group box 3

Loss of exosomal micro-RNA-200b-3p from hypoxia cancer-associated fibroblasts reduces sensitivity to 5-flourouracil in colorectal cancer through targeting high-mobility group box 3

Hypoxia-mediated tumor progression is a major problem in colorectal cancer (CRC). MicroRNA (miR)-200b-3p can attenuate tumorigenesis in CRC, while exosomal miRNAs derived from cancer-associated fibroblasts (CAFs) can promote cancer progression. Nevertheless, the function of exosomal miR-200b-3p deri...

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Bibliographic Details
Main Authors: Hang Yuan, Bingchen Chen, Rui Chai, Wenjing Gong, Ziang Wan, Boan Zheng, Xinye Hu, Yang Guo, Shan Gao, Qiaoqiong Dai, Peng Yu, Shiliang Tu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Oncology
Subjects:
miR-200b-3p directly targets HMGB3 CAFs
exosome
hypoxia
miR-200b-3p
HMGB3
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.920131/full

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