Interaction of Lipids, Mean Platelet Volume, and the Severity of Coronary Artery Disease Among Chinese Adults: A Mediation Analysis
ObjectiveCurrently, coronary artery disease (CAD) is regarded as one of the leading global disease burdens. Evidence proved that platelet activation in dyslipidemia induced CAD, however, their interaction has not been well-established in vivo. This study aims to assess the mediation effects of mean...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.753171/full |
| _version_ | 1818964915479642112 |
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| author | Yao Yao Xiaoye Li Zi Wang Qiuyi Ji Qing Xu Yan Yan Qianzhou Lv |
| author_facet | Yao Yao Xiaoye Li Zi Wang Qiuyi Ji Qing Xu Yan Yan Qianzhou Lv |
| author_sort | Yao Yao |
| collection | DOAJ |
| description | ObjectiveCurrently, coronary artery disease (CAD) is regarded as one of the leading global disease burdens. Evidence proved that platelet activation in dyslipidemia induced CAD, however, their interaction has not been well-established in vivo. This study aims to assess the mediation effects of mean platelet volume (MPV) in lipids and the severity of CAD.MethodsWe prospectively enrolled 5,188 consecutive subjects who underwent coronary angiography between 2015 and 2020. Participants were grouped according to their CAD events, which was defined as stenosis ≥50% in at least one coronary artery, and whose severity was evaluated by the Gensini score (GS). A lipid index was drawn by principal component analysis to weight related lipid parameters including total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), non-HDL-C, apolipoprotein (apo) A1 B. The interaction of lipids and MPV in atherosclerosis was evaluated by the mediation analysis.ResultsLipid index increased with elevated GS irrespective of statin status (not on statin: β = 0.100, p < 0.001; on statin: β = 0.082, p < 0.001). Multiple linear regression indicated positive correlation between MPV and GS after adjustment (β = 0.171, p < 0.001). Subjects in the highest MPV tertile had higher levels of atherogenic lipid parameters and lipid index (p < 0.001). The adjusted odds ratios were greater among individuals undergoing statin medications who had high GS and higher MPV levels by elevated lipid index tertiles [1.168 (0.893–1.528) vs. 2.068 (1.552–2.756) vs. 1.764 (1.219–2.551)]. The combination of lipid index and MPV provided better prediction for high GS than individual lipid index or MPV, as shown by receiver-operating characteristic (ROC) curves (areas under ROC curves were 0.700 and 0.673 in subjects on or not on statin treatment, respectively). Significantly, mediation analysis revealed the mediation interaction of lipid index on GS by MPV, whose effect size reached 20.71 and 20.07% in participants with or without statin medications.ConclusionThe increased risk of dyslipidemia on CAD was partly enhanced by elevated MPV levels, whose mediating effect was around 20%. |
| first_indexed | 2024-12-20T13:08:42Z |
| format | Article |
| id | doaj.art-72fd47a28a514f40876e2e6114fe36e1 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-20T13:08:42Z |
| publishDate | 2022-01-01 |
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| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-72fd47a28a514f40876e2e6114fe36e12022-12-21T19:39:42ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-01-01910.3389/fcvm.2022.753171753171Interaction of Lipids, Mean Platelet Volume, and the Severity of Coronary Artery Disease Among Chinese Adults: A Mediation AnalysisYao Yao0Xiaoye Li1Zi Wang2Qiuyi Ji3Qing Xu4Yan Yan5Qianzhou Lv6Department of Pharmacy, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Pharmacy, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Pharmacy, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Pharmacy, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Pharmacy, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Pharmacy, Zhongshan Hospital, Fudan University, Shanghai, ChinaObjectiveCurrently, coronary artery disease (CAD) is regarded as one of the leading global disease burdens. Evidence proved that platelet activation in dyslipidemia induced CAD, however, their interaction has not been well-established in vivo. This study aims to assess the mediation effects of mean platelet volume (MPV) in lipids and the severity of CAD.MethodsWe prospectively enrolled 5,188 consecutive subjects who underwent coronary angiography between 2015 and 2020. Participants were grouped according to their CAD events, which was defined as stenosis ≥50% in at least one coronary artery, and whose severity was evaluated by the Gensini score (GS). A lipid index was drawn by principal component analysis to weight related lipid parameters including total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), non-HDL-C, apolipoprotein (apo) A1 B. The interaction of lipids and MPV in atherosclerosis was evaluated by the mediation analysis.ResultsLipid index increased with elevated GS irrespective of statin status (not on statin: β = 0.100, p < 0.001; on statin: β = 0.082, p < 0.001). Multiple linear regression indicated positive correlation between MPV and GS after adjustment (β = 0.171, p < 0.001). Subjects in the highest MPV tertile had higher levels of atherogenic lipid parameters and lipid index (p < 0.001). The adjusted odds ratios were greater among individuals undergoing statin medications who had high GS and higher MPV levels by elevated lipid index tertiles [1.168 (0.893–1.528) vs. 2.068 (1.552–2.756) vs. 1.764 (1.219–2.551)]. The combination of lipid index and MPV provided better prediction for high GS than individual lipid index or MPV, as shown by receiver-operating characteristic (ROC) curves (areas under ROC curves were 0.700 and 0.673 in subjects on or not on statin treatment, respectively). Significantly, mediation analysis revealed the mediation interaction of lipid index on GS by MPV, whose effect size reached 20.71 and 20.07% in participants with or without statin medications.ConclusionThe increased risk of dyslipidemia on CAD was partly enhanced by elevated MPV levels, whose mediating effect was around 20%.https://www.frontiersin.org/articles/10.3389/fcvm.2022.753171/fullmediation analysismean platelet volumeserum lipidcoronary artery diseaseGensini score |
| spellingShingle | Yao Yao Xiaoye Li Zi Wang Qiuyi Ji Qing Xu Yan Yan Qianzhou Lv Interaction of Lipids, Mean Platelet Volume, and the Severity of Coronary Artery Disease Among Chinese Adults: A Mediation Analysis Frontiers in Cardiovascular Medicine mediation analysis mean platelet volume serum lipid coronary artery disease Gensini score |
| title | Interaction of Lipids, Mean Platelet Volume, and the Severity of Coronary Artery Disease Among Chinese Adults: A Mediation Analysis |
| title_full | Interaction of Lipids, Mean Platelet Volume, and the Severity of Coronary Artery Disease Among Chinese Adults: A Mediation Analysis |
| title_fullStr | Interaction of Lipids, Mean Platelet Volume, and the Severity of Coronary Artery Disease Among Chinese Adults: A Mediation Analysis |
| title_full_unstemmed | Interaction of Lipids, Mean Platelet Volume, and the Severity of Coronary Artery Disease Among Chinese Adults: A Mediation Analysis |
| title_short | Interaction of Lipids, Mean Platelet Volume, and the Severity of Coronary Artery Disease Among Chinese Adults: A Mediation Analysis |
| title_sort | interaction of lipids mean platelet volume and the severity of coronary artery disease among chinese adults a mediation analysis |
| topic | mediation analysis mean platelet volume serum lipid coronary artery disease Gensini score |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.753171/full |
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