Leukocyte as an Independent Predictor of Lower-Extremity Deep Venous Thrombosis in Elderly Patients With Primary Intracerebral Hemorrhage
ObjectiveDue to the interaction of leukocytes with platelets and coagulation factors, they may in turn play a role in hemostasis or the formation of thrombi. This study aimed to investigate the association of leukocytosis on admission with an increased risk of acute lower-extremity deep venous throm...
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.899849/full |
| _version_ | 1811225892944347136 |
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| author | Gang Wang Gang Wang Wenjun Zhao Zhiyong Zhao Zhiyong Zhao Dengfeng Wang Dengfeng Wang Dong Wang Dong Wang Ruobing Bai Ruobing Bai Boru Hou Boru Hou Haijun Ren Haijun Ren |
| author_facet | Gang Wang Gang Wang Wenjun Zhao Zhiyong Zhao Zhiyong Zhao Dengfeng Wang Dengfeng Wang Dong Wang Dong Wang Ruobing Bai Ruobing Bai Boru Hou Boru Hou Haijun Ren Haijun Ren |
| author_sort | Gang Wang |
| collection | DOAJ |
| description | ObjectiveDue to the interaction of leukocytes with platelets and coagulation factors, they may in turn play a role in hemostasis or the formation of thrombi. This study aimed to investigate the association of leukocytosis on admission with an increased risk of acute lower-extremity deep venous thrombosis (LEDVT) in elderly patients with primary intracerebral hemorrhage (ICH).MethodsThis was a single-center, retrospective observational study of consecutive patients observed with spontaneous ICH aged 60 years or above at Lanzhou University Second Hospital from January 2017 to September 2021. Clinical data and demographic information were collected and analyzed. Univariate and multivariate analyses were conducted to identify independent risk factors of acute LEDVT. One-to-one matching was implemented to balance important patient characteristics by the groups' propensity score matching (PSM) analysis.ResultsA total of 371 elderly patients with primary ICH fulfilled requirements for inclusion and exclusion, of whom 33 (8.89%) experienced LEDVT. Leukocyte counts were statistically higher in the LEDVT group compared to the non-LEDVT group [12.89 (8.80–14.61) × 109 cells/L vs. 8.31 (6.60–10.75) × 109 cells /L, p < 0.001]. Multivariate logistic regression models adjusted for several potential confounding factors were performed, and leukocytes were consistently a significant independent predictor of LEDVT. The optimal cut-off value of leukocyte counts calculated from the receiver operating characteristic (ROC) curve to predict LEDVT was 10.22 × 109 cells /L (area under the curve:0.714, 95%CI 0.665–0.759; the sensitivity was 72.73%; the specificity was 71.01%) in elderly patients with primary ICH. After one-to-one PSM, compared to the matched non-LEDVT group, the matched LEDVT group had significantly higher leukocyte counts [11.98 (8.40–13.94) × 109 cells/L vs. 6.12 (4.68–12.00) × 109 cells/L, p = 0.003]. After PSM, the ROC curve was plotted for leukocytes as a predictor of LEDVT, with an AUC of 0.722 (95%CI 0.593–0.828, p = 0.001; the sensitivity was 87.10%, and the specificity was 61.29%). Elevated leukocytes remained independently significant as predictors of LEDVT in elderly patients with primary ICH.ConclusionLeukocyte at admission is an independent risk factor of LEDVT in elderly patients with primary ICH. |
| first_indexed | 2024-04-12T09:16:09Z |
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| language | English |
| last_indexed | 2024-04-12T09:16:09Z |
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| spelling | doaj.art-72fd69746bc54838b14140bb844ba3eb2022-12-22T03:38:51ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-07-011310.3389/fneur.2022.899849899849Leukocyte as an Independent Predictor of Lower-Extremity Deep Venous Thrombosis in Elderly Patients With Primary Intracerebral HemorrhageGang Wang0Gang Wang1Wenjun Zhao2Zhiyong Zhao3Zhiyong Zhao4Dengfeng Wang5Dengfeng Wang6Dong Wang7Dong Wang8Ruobing Bai9Ruobing Bai10Boru Hou11Boru Hou12Haijun Ren13Haijun Ren14Department of Neurosurgery, Lanzhou University Second Hospital, Lanzhou, ChinaKey Laboratory of Neurology of Gansu Province, Lanzhou, ChinaDepartment of Health Management Center, Lanzhou University Second Hospital, Lanzhou, ChinaDepartment of Neurosurgery, Lanzhou University Second Hospital, Lanzhou, ChinaKey Laboratory of Neurology of Gansu Province, Lanzhou, ChinaDepartment of Neurosurgery, Lanzhou University Second Hospital, Lanzhou, ChinaKey Laboratory of Neurology of Gansu Province, Lanzhou, ChinaDepartment of Neurosurgery, Lanzhou University Second Hospital, Lanzhou, ChinaKey Laboratory of Neurology of Gansu Province, Lanzhou, ChinaDepartment of Neurosurgery, Lanzhou University Second Hospital, Lanzhou, ChinaKey Laboratory of Neurology of Gansu Province, Lanzhou, ChinaDepartment of Neurosurgery, Lanzhou University Second Hospital, Lanzhou, ChinaKey Laboratory of Neurology of Gansu Province, Lanzhou, ChinaDepartment of Neurosurgery, Lanzhou University Second Hospital, Lanzhou, ChinaKey Laboratory of Neurology of Gansu Province, Lanzhou, ChinaObjectiveDue to the interaction of leukocytes with platelets and coagulation factors, they may in turn play a role in hemostasis or the formation of thrombi. This study aimed to investigate the association of leukocytosis on admission with an increased risk of acute lower-extremity deep venous thrombosis (LEDVT) in elderly patients with primary intracerebral hemorrhage (ICH).MethodsThis was a single-center, retrospective observational study of consecutive patients observed with spontaneous ICH aged 60 years or above at Lanzhou University Second Hospital from January 2017 to September 2021. Clinical data and demographic information were collected and analyzed. Univariate and multivariate analyses were conducted to identify independent risk factors of acute LEDVT. One-to-one matching was implemented to balance important patient characteristics by the groups' propensity score matching (PSM) analysis.ResultsA total of 371 elderly patients with primary ICH fulfilled requirements for inclusion and exclusion, of whom 33 (8.89%) experienced LEDVT. Leukocyte counts were statistically higher in the LEDVT group compared to the non-LEDVT group [12.89 (8.80–14.61) × 109 cells/L vs. 8.31 (6.60–10.75) × 109 cells /L, p < 0.001]. Multivariate logistic regression models adjusted for several potential confounding factors were performed, and leukocytes were consistently a significant independent predictor of LEDVT. The optimal cut-off value of leukocyte counts calculated from the receiver operating characteristic (ROC) curve to predict LEDVT was 10.22 × 109 cells /L (area under the curve:0.714, 95%CI 0.665–0.759; the sensitivity was 72.73%; the specificity was 71.01%) in elderly patients with primary ICH. After one-to-one PSM, compared to the matched non-LEDVT group, the matched LEDVT group had significantly higher leukocyte counts [11.98 (8.40–13.94) × 109 cells/L vs. 6.12 (4.68–12.00) × 109 cells/L, p = 0.003]. After PSM, the ROC curve was plotted for leukocytes as a predictor of LEDVT, with an AUC of 0.722 (95%CI 0.593–0.828, p = 0.001; the sensitivity was 87.10%, and the specificity was 61.29%). Elevated leukocytes remained independently significant as predictors of LEDVT in elderly patients with primary ICH.ConclusionLeukocyte at admission is an independent risk factor of LEDVT in elderly patients with primary ICH.https://www.frontiersin.org/articles/10.3389/fneur.2022.899849/fulldeep vein thrombosisinflammationintracerebral hemorrhageleukocyteselderly |
| spellingShingle | Gang Wang Gang Wang Wenjun Zhao Zhiyong Zhao Zhiyong Zhao Dengfeng Wang Dengfeng Wang Dong Wang Dong Wang Ruobing Bai Ruobing Bai Boru Hou Boru Hou Haijun Ren Haijun Ren Leukocyte as an Independent Predictor of Lower-Extremity Deep Venous Thrombosis in Elderly Patients With Primary Intracerebral Hemorrhage Frontiers in Neurology deep vein thrombosis inflammation intracerebral hemorrhage leukocytes elderly |
| title | Leukocyte as an Independent Predictor of Lower-Extremity Deep Venous Thrombosis in Elderly Patients With Primary Intracerebral Hemorrhage |
| title_full | Leukocyte as an Independent Predictor of Lower-Extremity Deep Venous Thrombosis in Elderly Patients With Primary Intracerebral Hemorrhage |
| title_fullStr | Leukocyte as an Independent Predictor of Lower-Extremity Deep Venous Thrombosis in Elderly Patients With Primary Intracerebral Hemorrhage |
| title_full_unstemmed | Leukocyte as an Independent Predictor of Lower-Extremity Deep Venous Thrombosis in Elderly Patients With Primary Intracerebral Hemorrhage |
| title_short | Leukocyte as an Independent Predictor of Lower-Extremity Deep Venous Thrombosis in Elderly Patients With Primary Intracerebral Hemorrhage |
| title_sort | leukocyte as an independent predictor of lower extremity deep venous thrombosis in elderly patients with primary intracerebral hemorrhage |
| topic | deep vein thrombosis inflammation intracerebral hemorrhage leukocytes elderly |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.899849/full |
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