Transfer function analysis assesses resting cerebral perfusion metrics using hypoxia-induced deoxyhemoglobin as a contrast agent
Introduction: Use of contrast in determining hemodynamic measures requires the deconvolution of an arterial input function (AIF) selected over a voxel in the middle cerebral artery to calculate voxel wise perfusion metrics. Transfer function analysis (TFA) offers an alternative analytic approach tha...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-05-01
|
| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2023.1167857/full |
| _version_ | 1797828867250978816 |
|---|---|
| author | Ece Su Sayin Ece Su Sayin Olivia Sobczyk Olivia Sobczyk Julien Poublanc David J. Mikulis Joseph A. Fisher Joseph A. Fisher Joseph A. Fisher James Duffin James Duffin |
| author_facet | Ece Su Sayin Ece Su Sayin Olivia Sobczyk Olivia Sobczyk Julien Poublanc David J. Mikulis Joseph A. Fisher Joseph A. Fisher Joseph A. Fisher James Duffin James Duffin |
| author_sort | Ece Su Sayin |
| collection | DOAJ |
| description | Introduction: Use of contrast in determining hemodynamic measures requires the deconvolution of an arterial input function (AIF) selected over a voxel in the middle cerebral artery to calculate voxel wise perfusion metrics. Transfer function analysis (TFA) offers an alternative analytic approach that does not require identifying an AIF. We hypothesised that TFA metrics Gain, Lag, and their ratio, Gain/Lag, correspond to conventional AIF resting perfusion metrics relative cerebral blood volume (rCBV), mean transit time (MTT) and relative cerebral blood flow (rCBF), respectively.Methods: 24 healthy participants (17 M) and 1 patient with steno-occlusive disease were recruited. We used non-invasive transient hypoxia-induced deoxyhemoglobin as an MRI contrast. TFA and conventional AIF analyses were used to calculate averages of whole brain and smaller regions of interest.Results: Maps of these average metrics had colour scales adjusted to enhance contrast and identify areas of high congruence. Regional gray matter/white matter (GM/WM) ratios for MTT and Lag, rCBF and Gain/Lag, and rCBV and Gain were compared. The GM/WM ratios were greater for TFA metrics compared to those from AIF analysis indicating an improved regional discrimination.Discussion: Resting perfusion measures generated by The BOLD analysis resulting from a transient hypoxia induced variations in deoxyhemoglobin analyzed by TFA are congruent with those analyzed by conventional AIF analysis. |
| first_indexed | 2024-04-09T13:11:16Z |
| format | Article |
| id | doaj.art-7301816458004c009d79cb51b09b77e4 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-09T13:11:16Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-7301816458004c009d79cb51b09b77e42023-05-12T07:22:24ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2023-05-011410.3389/fphys.2023.11678571167857Transfer function analysis assesses resting cerebral perfusion metrics using hypoxia-induced deoxyhemoglobin as a contrast agentEce Su Sayin0Ece Su Sayin1Olivia Sobczyk2Olivia Sobczyk3Julien Poublanc4David J. Mikulis5Joseph A. Fisher6Joseph A. Fisher7Joseph A. Fisher8James Duffin9James Duffin10Department of Physiology, University of Toronto, Toronto, ON, CanadaDepartments of Anaesthesia and Pain Management, University Health Network, Toronto, ON, CanadaDepartments of Anaesthesia and Pain Management, University Health Network, Toronto, ON, CanadaJoint Department of Medical Imaging and the Functional Neuroimaging Laboratory, University Health Network, Toronto, ON, CanadaJoint Department of Medical Imaging and the Functional Neuroimaging Laboratory, University Health Network, Toronto, ON, CanadaJoint Department of Medical Imaging and the Functional Neuroimaging Laboratory, University Health Network, Toronto, ON, CanadaDepartment of Physiology, University of Toronto, Toronto, ON, CanadaDepartments of Anaesthesia and Pain Management, University Health Network, Toronto, ON, CanadaToronto General Hospital Research Institute, University Health Network, University of Toronto, Toronto, ON, CanadaDepartment of Physiology, University of Toronto, Toronto, ON, CanadaDepartments of Anaesthesia and Pain Management, University Health Network, Toronto, ON, CanadaIntroduction: Use of contrast in determining hemodynamic measures requires the deconvolution of an arterial input function (AIF) selected over a voxel in the middle cerebral artery to calculate voxel wise perfusion metrics. Transfer function analysis (TFA) offers an alternative analytic approach that does not require identifying an AIF. We hypothesised that TFA metrics Gain, Lag, and their ratio, Gain/Lag, correspond to conventional AIF resting perfusion metrics relative cerebral blood volume (rCBV), mean transit time (MTT) and relative cerebral blood flow (rCBF), respectively.Methods: 24 healthy participants (17 M) and 1 patient with steno-occlusive disease were recruited. We used non-invasive transient hypoxia-induced deoxyhemoglobin as an MRI contrast. TFA and conventional AIF analyses were used to calculate averages of whole brain and smaller regions of interest.Results: Maps of these average metrics had colour scales adjusted to enhance contrast and identify areas of high congruence. Regional gray matter/white matter (GM/WM) ratios for MTT and Lag, rCBF and Gain/Lag, and rCBV and Gain were compared. The GM/WM ratios were greater for TFA metrics compared to those from AIF analysis indicating an improved regional discrimination.Discussion: Resting perfusion measures generated by The BOLD analysis resulting from a transient hypoxia induced variations in deoxyhemoglobin analyzed by TFA are congruent with those analyzed by conventional AIF analysis.https://www.frontiersin.org/articles/10.3389/fphys.2023.1167857/fulltransfer function analysistransient hypoxiaMRIBOLD = blood oxygen level dependentcontrast agentsbrain |
| spellingShingle | Ece Su Sayin Ece Su Sayin Olivia Sobczyk Olivia Sobczyk Julien Poublanc David J. Mikulis Joseph A. Fisher Joseph A. Fisher Joseph A. Fisher James Duffin James Duffin Transfer function analysis assesses resting cerebral perfusion metrics using hypoxia-induced deoxyhemoglobin as a contrast agent Frontiers in Physiology transfer function analysis transient hypoxia MRI BOLD = blood oxygen level dependent contrast agents brain |
| title | Transfer function analysis assesses resting cerebral perfusion metrics using hypoxia-induced deoxyhemoglobin as a contrast agent |
| title_full | Transfer function analysis assesses resting cerebral perfusion metrics using hypoxia-induced deoxyhemoglobin as a contrast agent |
| title_fullStr | Transfer function analysis assesses resting cerebral perfusion metrics using hypoxia-induced deoxyhemoglobin as a contrast agent |
| title_full_unstemmed | Transfer function analysis assesses resting cerebral perfusion metrics using hypoxia-induced deoxyhemoglobin as a contrast agent |
| title_short | Transfer function analysis assesses resting cerebral perfusion metrics using hypoxia-induced deoxyhemoglobin as a contrast agent |
| title_sort | transfer function analysis assesses resting cerebral perfusion metrics using hypoxia induced deoxyhemoglobin as a contrast agent |
| topic | transfer function analysis transient hypoxia MRI BOLD = blood oxygen level dependent contrast agents brain |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2023.1167857/full |
| work_keys_str_mv | AT ecesusayin transferfunctionanalysisassessesrestingcerebralperfusionmetricsusinghypoxiainduceddeoxyhemoglobinasacontrastagent AT ecesusayin transferfunctionanalysisassessesrestingcerebralperfusionmetricsusinghypoxiainduceddeoxyhemoglobinasacontrastagent AT oliviasobczyk transferfunctionanalysisassessesrestingcerebralperfusionmetricsusinghypoxiainduceddeoxyhemoglobinasacontrastagent AT oliviasobczyk transferfunctionanalysisassessesrestingcerebralperfusionmetricsusinghypoxiainduceddeoxyhemoglobinasacontrastagent AT julienpoublanc transferfunctionanalysisassessesrestingcerebralperfusionmetricsusinghypoxiainduceddeoxyhemoglobinasacontrastagent AT davidjmikulis transferfunctionanalysisassessesrestingcerebralperfusionmetricsusinghypoxiainduceddeoxyhemoglobinasacontrastagent AT josephafisher transferfunctionanalysisassessesrestingcerebralperfusionmetricsusinghypoxiainduceddeoxyhemoglobinasacontrastagent AT josephafisher transferfunctionanalysisassessesrestingcerebralperfusionmetricsusinghypoxiainduceddeoxyhemoglobinasacontrastagent AT josephafisher transferfunctionanalysisassessesrestingcerebralperfusionmetricsusinghypoxiainduceddeoxyhemoglobinasacontrastagent AT jamesduffin transferfunctionanalysisassessesrestingcerebralperfusionmetricsusinghypoxiainduceddeoxyhemoglobinasacontrastagent AT jamesduffin transferfunctionanalysisassessesrestingcerebralperfusionmetricsusinghypoxiainduceddeoxyhemoglobinasacontrastagent |