Clinical and Prognostic Significance of Cell Sensitivity to Chemotherapy Detected in vitro on Treatment Response and Survival of Leukemia Patients
Multidrug resistance (MDR) is a major challenge in leukemia treatment. The objective of this study was to identity predictors of MDR to allow for rapid and economical assessment of the efficacy of planned antitumor therapy for leukemia patients. The study included 113 patients with acute and chronic...
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| Format: | Article |
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MDPI AG
2019-05-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/9/2/24 |
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| author | Maria Kolesnikova Aleksandra Sen’kova Sofia Tairova Viktor Ovchinnikov Tatiana Pospelova Marina Zenkova |
| author_facet | Maria Kolesnikova Aleksandra Sen’kova Sofia Tairova Viktor Ovchinnikov Tatiana Pospelova Marina Zenkova |
| author_sort | Maria Kolesnikova |
| collection | DOAJ |
| description | Multidrug resistance (MDR) is a major challenge in leukemia treatment. The objective of this study was to identity predictors of MDR to allow for rapid and economical assessment of the efficacy of planned antitumor therapy for leukemia patients. The study included 113 patients with acute and chronic leukemias. Prior to antitumor therapy, we measured the sensitivity of tumor cells of patients to the panel of chemotherapeutic drugs, together with <i>MDR1</i> mRNA and P-glycoprotein (P-gp) expression as one of the mechanisms of MDR, and compared these data with the response to therapy. The scales for leukemia patients according to therapy response, drug sensitivity of tumor cells, <i>MDR1</i> mRNA and P-gp levels, and the presence of unfavorable immunological and cytogenetic markers were introduced for subsequent correlation analysis. We show that the drug resistance of tumor cells of leukemia patients estimated in vitro at diagnosis correlates with a poor response to chemotherapy and is usually combined with aberrant and immature immunological markers, cytogenetic abnormalities, and a high expression of <i>MDR1</i> mRNA and P-gp. All together, these factors indicate unfavorable prognosis and low survival of leukemia patients. Thus, the sensitivity of tumor cells to chemotherapeutic drugs measured in vitro at diagnosis may have prognostic value for individual types of leukemia. |
| first_indexed | 2024-04-10T18:10:27Z |
| format | Article |
| id | doaj.art-7301d3fb65154e0e909f43e64fab741b |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-04-10T18:10:27Z |
| publishDate | 2019-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-7301d3fb65154e0e909f43e64fab741b2023-02-02T11:02:08ZengMDPI AGJournal of Personalized Medicine2075-44262019-05-01922410.3390/jpm9020024jpm9020024Clinical and Prognostic Significance of Cell Sensitivity to Chemotherapy Detected in vitro on Treatment Response and Survival of Leukemia PatientsMaria Kolesnikova0Aleksandra Sen’kova1Sofia Tairova2Viktor Ovchinnikov3Tatiana Pospelova4Marina Zenkova5Department of therapy, hematology and transfusiology, Novosibirsk State Medical University, Krasny Prospect 52, 630091 Novosibirsk, RussiaLaboratory of nucleic acids biochemistry, Institute of Chemical Biology and Fundamental Medicine SB RAS, Lavrentieva ave. 8, 630090 Novosibirsk, RussiaClinical and diagnostic laboratory, City Hematology Center, Polzunova Street 21, 630051 Novosibirsk, RussiaClinical and diagnostic laboratory, City Hematology Center, Polzunova Street 21, 630051 Novosibirsk, RussiaDepartment of therapy, hematology and transfusiology, Novosibirsk State Medical University, Krasny Prospect 52, 630091 Novosibirsk, RussiaLaboratory of nucleic acids biochemistry, Institute of Chemical Biology and Fundamental Medicine SB RAS, Lavrentieva ave. 8, 630090 Novosibirsk, RussiaMultidrug resistance (MDR) is a major challenge in leukemia treatment. The objective of this study was to identity predictors of MDR to allow for rapid and economical assessment of the efficacy of planned antitumor therapy for leukemia patients. The study included 113 patients with acute and chronic leukemias. Prior to antitumor therapy, we measured the sensitivity of tumor cells of patients to the panel of chemotherapeutic drugs, together with <i>MDR1</i> mRNA and P-glycoprotein (P-gp) expression as one of the mechanisms of MDR, and compared these data with the response to therapy. The scales for leukemia patients according to therapy response, drug sensitivity of tumor cells, <i>MDR1</i> mRNA and P-gp levels, and the presence of unfavorable immunological and cytogenetic markers were introduced for subsequent correlation analysis. We show that the drug resistance of tumor cells of leukemia patients estimated in vitro at diagnosis correlates with a poor response to chemotherapy and is usually combined with aberrant and immature immunological markers, cytogenetic abnormalities, and a high expression of <i>MDR1</i> mRNA and P-gp. All together, these factors indicate unfavorable prognosis and low survival of leukemia patients. Thus, the sensitivity of tumor cells to chemotherapeutic drugs measured in vitro at diagnosis may have prognostic value for individual types of leukemia.https://www.mdpi.com/2075-4426/9/2/24leukemiachemotherapydrug sensitivitymultidrug resistanceP-glycoprotein |
| spellingShingle | Maria Kolesnikova Aleksandra Sen’kova Sofia Tairova Viktor Ovchinnikov Tatiana Pospelova Marina Zenkova Clinical and Prognostic Significance of Cell Sensitivity to Chemotherapy Detected in vitro on Treatment Response and Survival of Leukemia Patients Journal of Personalized Medicine leukemia chemotherapy drug sensitivity multidrug resistance P-glycoprotein |
| title | Clinical and Prognostic Significance of Cell Sensitivity to Chemotherapy Detected in vitro on Treatment Response and Survival of Leukemia Patients |
| title_full | Clinical and Prognostic Significance of Cell Sensitivity to Chemotherapy Detected in vitro on Treatment Response and Survival of Leukemia Patients |
| title_fullStr | Clinical and Prognostic Significance of Cell Sensitivity to Chemotherapy Detected in vitro on Treatment Response and Survival of Leukemia Patients |
| title_full_unstemmed | Clinical and Prognostic Significance of Cell Sensitivity to Chemotherapy Detected in vitro on Treatment Response and Survival of Leukemia Patients |
| title_short | Clinical and Prognostic Significance of Cell Sensitivity to Chemotherapy Detected in vitro on Treatment Response and Survival of Leukemia Patients |
| title_sort | clinical and prognostic significance of cell sensitivity to chemotherapy detected in vitro on treatment response and survival of leukemia patients |
| topic | leukemia chemotherapy drug sensitivity multidrug resistance P-glycoprotein |
| url | https://www.mdpi.com/2075-4426/9/2/24 |
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